Volume 9, Issue 2

Kharadi Dhruvika Gaurang, Shah Agam Rajendra, Ganguly Barna

pp. 140–144 · DOI: 10.5530/jyp.2017.9.29

Aim:To Compare the safety of asenapine and iloperidone as per informa tion available in public domain. Method:In addition to their USFDA ap proved prescribing information, literature on these two drugs from Pubmed indexe…

K K Mueen Ahmed, S.M. Dhawan, B. M. Gupta, Madhu Bansal

pp. 145–157 · DOI: 10.5530/jyp.2017.9.30

Objectives:The main objective of this research is to identify highly cited papers in clinical pharmacology and to analyze their publication and citation data to study their citation characteristics, and understand what r…

Katharigatta Narayanaswamy Venugopala

pp. 158–161 · DOI: 10.5530/jyp.2017.9.31

Objective: Benzothiazole moiety containing various functional groups are found to have broad spectrum of biological activity and diverse chemical reactivity. The various pharmacological properties shown by the benzothia …

Panche Tulesh Kumar, Ghode Piyush, Jain Sanmati Kumar

pp. 162–167 · DOI: 10.5530/jyp.2017.9.32

Objective:Proviral integration site for moloney murine leukemia virus (PIM) kinases are among the contemporary targets for cancer chemotherapy as they play a pivotal role in inhibition of apoptosis and oncogenic signalin…

Vaithiyalingam Jagannathan Vishnuvarthan, Karunanidhi Santhanam Lakshmi, Ammayappan Rajam Srividya

pp. 168–171 · DOI: 10.5530/jyp.2017.9.33

Objective: Docking is one of the major tools in the drug development process, here we have selected certain flavonoid molecules such as Formononetin, Tangeritin, Myricetin and Kaempferol and we docked against Death Recep…

Aarti Belgamwar, Shagufta Khan, Lalit Rathi

pp. 172–176 · DOI: 10.5530/jyp.2017.9.34

Objective: To enhance solubility of efavirenz by using chitosan-graft-HPβCD copolymer synthesized by novel one pot technique. Methodology: Poor aqueous solubility and limited bioavailability is the major problem for more…

Jayaseelan Kavitha, Karunanidhi Santhana Lakshmi

pp. 177–182 · DOI: 10.5530/jyp.2017.9.35

Objective:A rapid, simple and economic RP-TLC/Densitometry method for the simultaneous quantification of Phthalates, namely Dimethyl Phthalate (DMP), Diethyl Phthalate (DEP) and Di-n-butyl Phthalate (DBP) in Personal car…

Iyan Sopyan, Achmad Fudholi, Muchtaridi Muchtaridi, Ika Puspita Sari

pp. 183–186 · DOI: 10.5530/jyp.2017.9.36

Objective : The aim of this study was to explore co-crystallization to enhance the solubility of simvastatin (SV) as a drug of choice for hypercholesterolemia using saccharin (Sacch) as co-former. Methods: Molecular mode…

E. Bhargav, C.Surya Prakash Reddy, C. Sowmya, C. Haranath, K. Arshad Ahmed Khan, K. Rajesh, B. Srinath

pp. 187–191 · DOI: 10.5530/jyp.2017.9.37

Objective:The present work was designed to formulate and optimize Orodispersible tablets of Piroxicam using QbD approach. The central composite design tool was used to evaluate the scientific understanding of input and o…

Moumita Das, Bijaya Ghosh, Swapnoleena Sen, L. K. Ghosh

pp. 192–196 · DOI: 10.5530/jyp.2017.9.38

Objective:Formulations were developed for targeted controlled delivery of 5-fluorouracil at the colonic site.Methods:Probable dose for drug loading in the tablets and duration of drug release at the colon was determined.…

Ramalingam Peraman, SubbaRao Dakinedi, Rajesh Reddy Kadiri, Lavanya malineni

pp. 197–202 · DOI: 10.5530/jyp.2017.9.39

Objective:The objective of the proposed method was to develop an accurate, rapid and cost-effective stability indicating a reversed phase high-performance liquid chromatographic method for the determination of azilsartan…

Fatima Sanjeri Dasankoppa, Vinuta Mallikarjun Sajjanar, Hasanpasha Sholapur, N.G. Nanjundaswamy, Kiran Ashok Kubasad, Pooja Mohan Walvekar

pp. 203–208 · DOI: 10.5530/jyp.2017.9.40

Background:Rosuvastatin calcium exhibits poor oral bioavailability due to extensive pre-systemic metabolism. Orodispersible tablets (ODTs) were prepared that disintegrate rapidly in oral mucosa thus preventing pre- syste…

Manish Kumar Thimmaraju, Khaggeswar Bheemanapally, Rajkumar Dharavath, Lavanya Kakarla, Mahendran Botlagunta

pp. 209–213 · DOI: 10.5530/jyp.2017.9.41

Objective: The aim of the present study is to prepare poloxamer based formulations of meloxicam to evaluate various parameters like pH stability, drug release and in vitro anticancer activities in cell lines with an inte…

Srikrishnan Rajendran Sri Ramkumar, Natesan Sivakumar, Jaya Balaji Mano Christaine Angelo

pp. 214–217

Background:Many research works are being carried out in preparing intra canal medicaments using herbal plants since it is safe as well as containing a better therapeutic value. The present study was designed to evaluate …

Sathianarayanan s, Amrutha B Chittethu, Asha Jose, Ranganathan Balasubramanian, Saranya TS, Asha Asokan Manakadan

pp. 218–223 · DOI: 10.5530/jyp.2017.9.43

Objective:The present study was aimed to determine cytotoxic and apoptotic activity of isatin semicarbazones against mammary carcinoma. Methodology: The preparation of these target compounds involved substitution at the …

Zarrin Sarhadynejad, Abbas Pardakhty, Ali Mandegary, Suleiman Afsharypuor, Fariba Sharififar

pp. 224–229 · DOI: 10.5530/jyp.2017.9.44

Objective: Quality control and standardization of traditional preparations ensure their safe, pure and efficient prescription. Zereshk-e-Saghir (ZES), a folk remedy, has been recommended as a hepatoprotective agent in Tr…

Kailash S. Chadchan, Swastika N. Das, Jameel G. Jargar, Kusal K. Das

pp. 230–233 · DOI: 10.5530/jyp.2017.9.45

Objective: To compare anti-diabetic effect between the different aqueous extracts of green leafy plants locally available in North Karnataka region of India on alloxan induced diabetic male albino rats. Materials and Met…

Sai Sruthi Kaveripakam, Sreedevi Adikay, Gandhimathi Retnasamy

pp. 234–238 · DOI: : 10.5530/jyp.2017.9.46

Objective:The present study was designed to evaluate the anti-obesity efficacy of ethanol extract of roots of Stereospermum suaveolens on high fat fed obese rats. Methodology:Ethanol extract of roots was prepared by hot …

Vijay R. Chidrawar, Krishnapriya Pegalapati, Pavani Ade, Abdulkhaliq J. Alsalman, Shruti Shiromwar

pp. 239–245 · DOI: 10.5530/jyp.2017.9.47

Background: Ca2+ channels and calcium signalling appears to play a critical role in the differentiation and functions of osteoclasts and osteoblasts and L-types voltage dependent calcium channels (VDCC) are expressed on …

Rohini S. Kori, Ravindranath H. Aladkatti, S.D. Desai, Kusal K.Das

pp. 246–250 · DOI: 10.5530/jyp.2017.9.48

Objective: In this study we investigated the effect of Fluoxetine, a selective serotonin reuptake inhibitor, on the gravimetry, hematology and whole brain histopathology in the restrained stressed male albino rats. Metho…