Hepatoprotective and antibacterial activity of Lippia nodiflora Linn. against lipopolysaccharides on HepG2 cells
S. Arumanayagam1★, M. Arunmani2★ Corresponding author
- 1Department of Pathology, Methodist Hospital Research Institute, Houston, USA.
- 2Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.
CORRESPONDENCE
S. Arumanayagam
Department of Pathology, Methodist Hospital Research Institute, Houston, USA.
Received: 14-05-2014; Revised: 27-05-2014.
Volume 11, Issue 41 · pp. 24–31 · PUBLISHED 21 January 2015 · DOI: 10.4103/0973-1296.149689
ABSTRACT
Background: Lippia nodiflora (LN) Linn is a small herb distributed throughout the world. The plant extracts of LN is used traditionally as an analgesic, anti‑inflammatory, antioxidant, antibacterial, antimicrobial, antipyretic, antitumor, antidiabetic, and possess hepatoprotective properties. Materials and Methods: To study the antibacterial and hepatoprotective effect of LN, we used methanolic extracts of leaves on HepG2 cells. Lipopolysaccharides (LPS) is a well‑characterized hepatotoxin, so toxicity was induced on liver cells using LPS. Up‑regulation of inflammation genes were quantified. Results and Conclusions: In our present study, we have showed that LN reduced reactive oxygen species (ROS) production against LPS induced toxicity on HepG2 cells, and ther by decreased the apoptotic gene expression and protect the liver cells against toxicity.
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Arumanayagam, S., & Arunmani, M. (2015). Hepatoprotective and antibacterial activity of Lippia nodiflora Linn. against lipopolysaccharides on HepG2 cells. Pharmacognosy Magazine, 11(41), 24–31. https://doi.org/10.4103/0973-1296.149689