Effect of Shankhpushpi on Alcohol Addiction in Mice
Mahi Heba1, Sana Faraz1, Sugato Banerjee1★★ Corresponding author
- 1Department of Pharmaceutical Science and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.
CORRESPONDENCE
Sugato Banerjee
Department of Pharmaceutical Science and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.
Received: 18-08-2016; Revised: 24-10-2016; Accepted: 24-10-2016.
Volume 13, Issue 49S · pp. 148–53 · PUBLISHED 7 April 2017 · DOI: 10.4103/0973-1296.203976
ABSTRACT
Alcohol addiction is a worldwide problem. It has mainly two components: dependence and withdrawal. Characteristic properties of most anti-addictive compounds include anti-anxiety, anticonvulsant, antidepressant, and nootropic actions. Shankhpushpi (Convolvulus pluricaulis. Convolvulaceae), known ethnopharmacologically as brain tonic, possess all the properties mentioned above. Here, we screen shankhpushpi for possible anti-addictive potential. Effect of shankhpushpi churna was measured on ethanol withdrawal anxiety using elevated plus maze. The role of shankhpushpi on chronic ethanol consumption (21 days) was measured using two bottle choice protocol of voluntary drinking. We also measured the effect of the above herb on cortico-hippocampal GABA levels. Shankhpushpi was found to reduce alcohol withdrawal anxiety in a dose-dependent manner. The herb also decreased ethanol intake and increased water intake significantly (P < 0.001) after 4 days of administration. Both these effects were blocked (P < 0.001) by GABAA antagonist suggesting the role of GABAA receptor. Chronic administration of shankhpushpi also significantly (P < 0.01) increased cortico-hippocampal GABA levels in mice. Shankhpushpi reduced both alcohol dependence and withdrawal in a GABAA-dependent manner, thus showing anti-addictive potential.
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Heba, M., Faraz, S., & Banerjee, S. (2017). Effect of Shankhpushpi on Alcohol Addiction in Mice. Pharmacognosy Magazine, 13(49S), 148–53. https://doi.org/10.4103/0973-1296.203976