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Article

Immunomodulatory, Cytotoxicity, and Antioxidant Activities of Roots of Ziziphus mauritiana

Samina Afzal1★, Murium Batool2, Bashir Ahmad Ch1, Ashfaq Ahmad3, Muhammad Uzair1, Khurram Afzal3★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University.
  2. 2Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  3. 3Department of Physiology and Pharmacology, Universiti Sains Malaysia, 11800 Penang, University, Malaysia.

CORRESPONDENCE

Samina Afzal

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University.

samina.afzal@bzu.edu.pk

Received: 10-09-2016; Revised: 08-11-2016.

Volume 13, Issue 50S · pp. S262–S265 · PUBLISHED 11 July 2017 · DOI: 10.4103/pm.pm_398_16

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ABSTRACT

Aims: The study is conducted to evaluate the immunomodulatory, cytotoxicity, and antioxidant potential of Ziziphus mauritiana (Rhamnaceae). Phytochemical analysis of Z. mauritiana revealed the presence of alkaloids, anthraquinone glycoside, cardiac glycoside, saponin, tannin, and flavonoids. Methodology: The cytotoxicity of the plant Z. mauritiana was evaluated by brine shrimp lethality test. Antioxidant parameters such as superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and malondialdehyde (MDA) levels were calculated in the plasma of rats after chronic administration of 400 mg/kg of Z. mauritiana for 6 weeks. Results: The dichloromethane extract of the plant exhibited significant immunomodulatory activity, with inhibitory concentration 50% of 55.43 ± 7.9. The dichloromethane extracts of the plant showed 70% mortality at concentration 1000 µg/ml. SOD and T-AOC levels were increased while MDA level in the plasma was reduced in the plasma of rats treated with dichloromethane Z. mauritiana. Conclusion: This can be deduced that the root of Z. mauritiana has immunomodulatory, cytotoxic, and antioxidant potential.

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    Afzal, S., Batool, M., Ch, B. A., Ahmad, A., Uzair, M., & Afzal, K. (2017). Immunomodulatory, Cytotoxicity, and Antioxidant Activities of Roots of Ziziphus mauritiana. Pharmacognosy Magazine, 13(50S), S262–S265. https://doi.org/10.4103/pm.pm_398_16