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Article

Immunomodulatory and anti‑tumor effects of Nigella glandulifera freyn and sint seeds on ehrlich ascites carcinoma in mouse model

Ainiwaer Aikemu1, Xiadiya Xiaerfuding2, Chengyufeng Shiwenhui3, Meiliwan Abudureyimu1, Dilinuer Maimaitiyiming4★★ Corresponding author

  1. 1Department of Drug Analysis, College of Pharmacy, Xinjiang Medical University, 830011 Urumqi, Xinjiang, China.
  2. 2Teaching and Research Section of Health Service Management, College of Public Health, Xinjiang Medical University.
  3. 3Department of Animal Experiment, Urumqi General Hospital of Lanzhou Military.
  4. 4Heart Internal Medicine Center, The first affiliated hospital of Xinjiang Medical University, 830011 Urumqi, Xinjiang, Chinaa.

CORRESPONDENCE

Dilinuer Maimaitiyiming

Heart Internal Medicine Center, The first affiliated hospital of Xinjiang Medical University, 830011 Urumqi, Xinjiang, Chinaa.

115149469@qq.com

Received: 01-06-2012; Revised: 08-08-2012.

Volume 9, Issue 35 · pp. 187–191 · PUBLISHED 11 June 2013 · DOI: 10.4103/0973-1296.113258

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ABSTRACT

Aim: This study investigated the immunomodulatory and anti‑tumor effects of Nigella glandulifera Freyn and Sint seeds (NGS) on Ehrlich ascites carcinoma in a mouse model. Materials and Methods: Kunming mice with transplanted Ehrlich ascites tumor cells (EAC) were treated with NGS by oral administration. On the 11th day after the EAC implant, mouse thymus, liver, spleen and kidney tumors were removed for histopathological analysis. Blood samples were taken for hematological and biochemical analyses. Results: The results indicate that NGS treatment leads to an increase in TNF-α, IL-1β, and IL-2 blood serum levels. Absence of viable EAC and presence of necrotic cells were observed in the tumor tissue of the NGS-treated animals. Conclusions: The study results indicated that a water extract of NGS had the highest anti‑tumor effect. Moreover, NGS treatment also showed an increase in the immune system activity.

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    Aikemu, A., Xiaerfuding, X., Shiwenhui, C., Abudureyimu, M., & Maimaitiyiming, D. (2013). Immunomodulatory and anti‑tumor effects of Nigella glandulifera freyn and sint seeds on ehrlich ascites carcinoma in mouse model. Pharmacognosy Magazine, 9(35), 187–191. https://doi.org/10.4103/0973-1296.113258