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Article

Interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42)

Li Shuai1★, Zhi Chen2, Ruixi Gao1, Tianming Yang1★ Corresponding author

  1. 1College of Pharmacy, South-Central University for Nationalities, Minyuan Road 708, Hongshan District, Wuhan, Hubei, 430074, China.
  2. 2Center of Analysis, Guangdong Medical College, Dongguan, 523808, P. R, China.

CORRESPONDENCE

Li Shuai

College of Pharmacy, South-Central University for Nationalities, Minyuan Road 708, Hongshan District, Wuhan, Hubei, 430074, China.

shuaich@163.com

Received: 20-06-2012; Revised: 03-10-2012.

Volume 9, Issue 35 · pp. 196–201 · PUBLISHED 11 June 2013 · DOI: 10.4103/0973-1296.113262

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ABSTRACT

Background: Lobed kudzuvine root and rhizoma chuanxiong are effective drugs in traditional Chinese medicine. Objective: Extracts of the two medicines were investigated for their in vitro of beta-amyloid (Aβ1-42)-aggregation-and acetylcholinesterase (AChE)-inhibitory activities. Materials and Methods: The interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42) were studied by Michaelis–Menten equations, Thioflavin T (ThT) fluorescence analysis and transmission electron microscope (TEM). Results: Inhibition of acetylcholinesterase showed that 1-butanol fraction of the two medicines were noncompetitive inhibition, apparent inhibition constants were 9.947 and 7.1523. ThT fluorescence analysis and TEM results indicated that inhibition of the water fraction and 1-butanol fraction (both lobed kudzuvine root and rhizoma chuanxiong) was better. Conclusion: The result supported further research on chemical constituents and pharmacological mechanisms.

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    Shuai, L., Chen, Z., Gao, R., & Yang, T. (2013). Interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42). Pharmacognosy Magazine, 9(35), 196–201. https://doi.org/10.4103/0973-1296.113262