Volume 17, Issue 73

Physalis peruviana Juice and Seeds Methanolic Extracts; Gas Chromatography Mass Spectrometry; Antioxidant and Anticancer against Human A549, HepG2

Ahmed Gomaa Darwish, Emad Sabry Shaker

pp. 1–5 · DOI: 10.4103/pm.pm_262_20 · Published 15 April 2021

Objectives: Physalis peruviana L. is a medicinal herb and its consumption increases annually in The Middle East, also the scientific research on it increases due to its valuable nutrient. Materials and Methods: Methanoli…

Spectrum–Effect Relationships between Fingerprints of Radix Polygoni multiflori‑Achyranthes bidentate and Antiosteoporosis Effect Based on Different Extraction Solvents

Sun Yan‑Tao, Wang Bing, Kang Ting‑Guo

pp. 16–22 · DOI: 10.4103/pm.pm_258_20 · Published 15 April 2021

Background: Polygonum multiflorum and Achyranthes bidentate are traditional Chinese herbs, which show significant antiosteoporosis (OP) effect. These two herbs are commonly used as a combination in traditional Chinese me…

Vasorelaxant and Antioxidant Activity of Some Medicinal Plants from Campeche, Mexico

Francisco Javier Aguirre Crespo, Elias Cerino Pérez, Janice D. G. Valdovinos Estrella, Maria G. Maldonado Velazquez, Benjamin O. Ortega Morales, Pedro Zamora Crecencio, Emanuel Hernández Nuñez, Samuel E. Estrada Soto

pp. 23–30 · DOI: 10.4103/pm.pm_291_20 · Published 15 April 2021

Aim: Methanol leaves extracts of these plants were use as raw material to develop a phytochemical, spectroscopy, and pharmacological analysis. Subjects and Methods: Methanol maceration was carried out and were compared i…

The Inhibitory Effects of Different Kinds of Ginsenosides on Skin Pigmentation in Melasma Mice Model

Shengxue Zhou, Songyan Xu, Haitao Li, Chunlin Zhao

pp. 31–37 · DOI: 10.4103/pm.pm_9_20 · Published 15 April 2021

Objectives: The study was aimed to compare the effects of seven different kinds of ginsenosides and total saponins on melasma and to explore their related mechanisms. Materials and Methods: The inhibitory rate of ginseno…

Caffeic Acid Treatment Augments the Cell Proliferation, Differentiation, and Calcium Mineralization in the Human Osteoblast‑Like MG‑63 Cells

Lili Liu, Hong Mu, Ying Pang

pp. 38–44 · DOI: 10.4103/pm.pm_186_20 · Published 15 April 2021

Objectives: The current study was planned to examine the potential of Caffeic acid in proliferation, differentiation, and calcium mineralization of osteoblast‑like MG‑63 cells. Materials and Methods: The cell viability o…

Dieckol Attenuates Cell Proliferation in Molt‑4 Leukemia Cells via Modulation of JAK/STAT3 Signaling Pathway

Ai Li, Li Zhang, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Juandong Wang

pp. 45–50 · DOI: 10.4103/pm.pm_2_20 · Published 15 April 2021

Background: Leukemia is a cancer of the hematopoietic stem cells, which leads to an uncontrolled proliferation of leukocytes in blood. It is responsible for one of the most important cancer‑associated deaths across the g…

Immunomodulatory Effect of d‑Carvone in Swiss Albino Mice with Benzo(a)pyrene‑Induced Lung Cancer

Sujuan Zhang, Lixin Bi, Qian Wang, Dong Wang, Yanqing Tian, Zhiqing Zheng, Yanzhou Han

pp. 51–57 · DOI: 10.4103/pm.pm_508_19 · Published 15 April 2021

Objective: In this study, we examined the immunomodulatory effect of d‑carvone in the Swiss albino mice model against benzo(a) pyrene (BaP)‑induced lung carcinoma. Materials and Methods: BaP was orally administered to th…

β-caryophyllene, a Natural Bicyclic Sesquiterpene, Induces Apoptosis by Inhibiting Inflammation-Associated Proliferation in MOLT-4 Leukemia Cells

Xuezhong Gu$, Xiangmei Yao$, Jian Mei, Haitao He, Xiaoli Gao, Yunyun Du, Jie Zhao, Liangyun Zhao, Xun Lai, Keqian Shi

pp. 58–66 · DOI: 10.4103/pm.pm_550_19 · Published 15 April 2021

Background: Leukemia is known to be a common type of cancer mostly affecting children. The standard therapeutic treatment available for leukemia has many drawbacks with serious side effects. Therefore, plant‑based chemot…

Chemical Composition and Neurotherapeutic Potential of Glaucium corniculatum Extracts

Fatma Gonca Kocanci, Belma Aslim

pp. 67–75 · DOI: 10.4103/pm.pm_348_20 · Published 15 April 2021

Objectives: The present study examines the possible suppressive effects on apoptosis of three different G. corniculatum extracts (chloroform, methanol, and water) in neuronal‑differentiated PC12 (dPC12) cells induced by …

Rehmannia glutinosa Polysaccharide Increases the Expression of Erythropoietin and Vascular Endothelial Growth Factor in Rats with Chronic Renal Failure by Activating Hypoxia‑Inducible Factor‑2α

Hao Liu, Li‑Li Su, Yan Ren, Wen‑Ying Wang

pp. 76–83 · DOI: 10.4103/pm.pm_13_20 · Published 15 April 2021

Background: To investigate the effect of Rehmannia glutinosa polysaccharide (RGP) in rats with chronic renal failure. Materials and Methods: In this study, we established a rat model of adenine‑induced chronic renal fail…

An Edible Bioactive Fraction from Rosa multiflora Regulates Adipogenesis in 3T3‑L1 Adipocytes and High‑Fat Diet‑Induced C57Bl/6 Mice Models of Obesity

H. V. Sudeep, K. Gouthamchandra, I. Ramanaiah, Amritha Raj, Shyamprasad K

pp. 84–92 · DOI: 10.4103/pm.pm_175_20 · Published 15 April 2021

Objectives: Rose varieties are cultivated worldwide for ornamental flowers and have been greatly valued in the cosmetics and medicinal applications. Medicinal preparations from the different parts of the rose, including …

Targeted Metabolomic Analysis of Seven Short‑Chain Fatty Acids in Feces of Rats with Spleen‑Deficiency Syndrome after Administering Raw and Bran‑Fried Atractylodis Rhizoma by Gas Chromatography‑Mass Spectrometer

Shanpeng Ma, Donghua Xue, Beixue Zhang, Yujun Jiang, Qian Cai

pp. 93–100 · DOI: 10.4103/pm.pm_185_20 · Published 15 April 2021

Aim: The aim of this study was to compare the difference between raw and BFA acting on short‑chain fatty acid (SCFA) metabolism in SDS rats, a metabolic pathway comprising gut flora. Materials and Methods: The model of S…

Antiproliferative and Apoptosis Inducing Effect of Delphinidin against Human Bladder Cancer Cell Line

Yufu Kang, Jingchao Li, Li Jing, Yanling Zhang, Xiangbo Wang

pp. 101–105 · DOI: 10.4103/pm.pm_548_19 · Published 15 April 2021

Background: Urinary bladder cancer is one of the leading causes of death worldwide. This study was conducted to evaluate the effect of delphinidin on proliferation, apoptosis, and cell cycle arrest in the urinary bladder…

Identification of Differentially Expressed Genes and Biological Pathways in Sanguinarine‑treated Ovarian Cancer by Integrated Bioinformatics Analysis

Haiting Yu, Abdelkerim Barh Touna, Xueqin Yin, Qin Zhang, Tianyan Leng, Lihua Yang

pp. 106–111 · DOI: 10.4103/pm.pm_111_20 · Published 15 April 2021

Aim: This study was intended to identify potentially target genes and underlying biological pathway of sanguinarine in ovarian cancer. Methods: We obtained the expression changes of downstream target genes and underlying…

Therapeutic Effect of Huzhangoside D in Rats with Knee Osteoarthritis Induced by Anterior Cruciate Ligament Transection

Ruo Jing Zhang, Cheng Chen Cai, Jian Pang, Xiao Li Xu, Hai Xin Gou, Guo Wen Li

pp. 112–119 · DOI: 10.4103/pm.pm_298_20 · Published 15 April 2021

Background: Knee osteoarthritis (KOA) is an age‑related disease. Huzhangoside D is a saponin isolated from genus Clematis L. (Ranunculaceae). The aim of this study is to explore the anti‑inflammatory, apoptotic, and auto…

Evaluation of Antioxidant and Anti-inflammatory Activities of Selected Cissus Species

Preeti Rawat, Pinki Rawat, Piyush Kumar, Sabita Kumari, Anil Kumar, Mahesh Pal

pp. 120–126 · DOI: 10.4103/pm.pm_333_20 · Published 15 April 2021

Objectives: The present work was aimed at investigating the phytochemicals of methanolic extract of L. procumbens leaves and its isolated mixtures from column fractions. Materials and Methods: The method was successfully…

Anticancer Activity of Abietane Diterpenoids from Salvia libanoticum Grown in Lebanon

Mohamad Ali Hijazi, Khadija Hijazi, Kamal Bouhadir, Zaynab Fatfat, Maha Aboul‑Ela, Hala Gali‑Muhtasib

pp. 127–133 · DOI: 10.4103/pm.pm_265_20 · Published 15 April 2021

Objectives: The objectives were to evaluate the potential of abietane diterpenes from the roots of Salvia libanoticum as anticancer agents and explore some essential chemical features. Materials and Methods: Crude extrac…

Skin‑Healing Properties of Ginsenoside Rd against Ultraviolet‑B‑Induced Photooxidative Stress through Up‑Regulation of Antioxidant Components in HaCaT Keratinocytes

Yoonjin Lee, Hye‑Won Lim, Ji‑Young Yoon, Suyeon Lee, In Wang Ryu, Minsik Park, Young Min Chi, Chang‑Jin Lim

pp. 134–139 · DOI: 10.4103/pm.pm_319_20 · Published 15 April 2021

Objectives: This work assesses the antioxidant and protective potentials of Rd against ultraviolet (UV)‑B‑induced skin photooxidative stress in HaCaT keratinocytes. Materials and Methods: Cell viability was detected usin…

Protective Effects of Ginsenoside Rh1 on Intervertebral Disc Degeneration through Inhibition of Nuclear Factor Kappa‑B Signaling Pathway

Shuping Zhang, Tong Wang, Xuexin Wang, Yanan Wang, Peng Wang, Jinxia Li, Zhenyu Wang, Faliang Lin

pp. 140–145 · DOI: 10.4103/pm.pm_579_19 · Published 15 April 2021

Background: In this study, we aim to explore the protective effect of ginsenoside Rh1 against intervertebral disc degeneration (IDD) and the related mechanism. Materials and Methods: IDD model in Sprague‑Dawley rats was …

Novel Mathematical Model for the Assessment of Similarity of Chromatographic Fingerprints of Volatile Oil from Houttuynia cordata

Jin Zhou, Qimeng Fan, Yutian Zhang, Roxanne Castillo, Meifeng Xiao, Hui Liu, Zhifei Zhu, Youzhi Liu, Yantao Yang, Yiqun Zhou, Xue Pan, Fuyuan He

pp. 154–162 · DOI: 10.4103/pm.pm_192_20 · Published 15 April 2021

Objectives: In this study, we aimed to develop a novel mathematical model to analyze the similarity of the chromatographic fingerprints of Houttuynia cordata (HC). Materials and Methods: Total quantum statistical moment …

Bilobalide, A Bioactive Compound on Sepsis‑Induced Acute Lung Injury through its Anti‑Inflammatory and Antioxidative Activity

Feng Wang, Jian Huang, Jun Li, Kang Chen, Xuegang Zhang, Yong Zhang, Yi Zhu

pp. 163–169 · DOI: 10.4103/pm.pm_448_20 · Published 15 April 2021

Background: Sepsis, one of the major life‑threatening conditions and responsible for approximately 40% of clinical Acute Lung Injury (ALI) patients. Nevertheless, there are no specific medications available to reduce mor…

Garden Cress (Lepidium sativum L.) Seeds Enhancing Osteogenesis Postinduced‑Bone Fracture

Fatma H. Alharbi, Othman A. S. Baothman, Mazin A. Zamzami, Hoda H. Abou Gabal, Samir M. Khoja, Gamal Karrouf, Mustafa A Zeyadi, Salman B. Hosawi, Khalid Rehman Hakeem, Mohamed Kamel Abo-Golayel

pp. 170–178 · DOI: 10.4103/pm.pm_75_20 · Published 15 April 2021

Objectives: This study is aimed to evaluate the role of garden cress seeds (GCS) in osteogenic enhancement in bone fractures induced in rabbits. Materials and Methods: Thirty New Zealand White rabbits (Oryctolagus cunicu…

Salidroside Induces Apoptosis and Autophagy in Gastric Cancer Cells via Regulation of Mitogen‑Activated Protein Kinases Signaling Pathway

Canhong Hu, Shao Xiang, Lingchang Li, Feng Xia Qin, Guoli Wei, Xiaofei Huang, Rong Ding, Jiege Huo, Zhijun Fang

pp. 179–185 · DOI: 10.4103/pm.pm_119_20 · Published 15 April 2021

Background: Salidroside, an active ingredient of Rhodiola rosea, exhibits antiproliferative effect in gastric cancer (GC) cells. However, the involvement of salidroside in apoptosis and autophagy of GC cells has not been…

Neuroprotective Effect of Neferine, an Alkaloid against the 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine Induced Parkinson’s Disease Mouse Model

Shendong Jing, Zhenhai Wang, Jun Zhang, Xianfeng Li, Ruifei Huang

pp. 186–192 · DOI: 10.4103/pm.pm_291_19 · Published 15 April 2021

Background: Parkinson’s disease (PD) is the second most chronic neurodegenerative disorders affecting the age‑old peoples worldwide. Therefore, in the present study, we assessed the neuroprotective effect of neferine aga…

Eriocitrin Alleviates the Arterial Occlusion‑Mediated Cerebral Ischemic‑Reperfusion Injury through the Modulation of Apoptotic Proteins and Immune Markers in Mice

Xueming Duan¶, Youguo Hao1¶, Xinxin Liang, Guoqiang Qiu, Weixiang Xue

pp. 193–199 · DOI: 10.4103/pm.pm_577_19 · Published 15 April 2021

Background: Stroke is ranked on top of the persistent ailments associated with the brain. The incidence of ischemic stroke is rapidly rising along with intensified mortality as well as permanent disability conditions. Ho…

Retraction: Protective Effect of Viburnum Grandiflorum against Ultraviolet B Radiation-Induced Cellular and Molecular Changes in Human Epidermal Keratinocytes

pp. 207–207 · DOI: 10.4103/0973-1296.312818 · Published 2020

Erratum: Chemical Composition and Biological Potential of a Chloroform Fraction from the Leaves of Marine Plant Syringodium filiforme Kutzing

pp. 208–208 · DOI: 10.4103/0973-1296.313548 · Published 2020