Evaluation of Bacillus cereus and Bacillus pumilus metabolites for anthelmintic activity
M. L. Vijaya Kumar1, B. Thippeswamy2★, I. L. Kuppust1, K. J. Naveenkumar2, C. K. Shivakumar2★ Corresponding author
- 1Department of Pharmacognosy, National College of Pharmacy
- 2Department of Microbiology, Kuvempu University, Shankarghatta, Shimoga, Karnataka, India
CORRESPONDENCE
B. Thippeswamy
*Address for correspondence: Dr. B. Thippeswamy, Department of Microbiology, Kuvempu University, Shankarghatta, Shimoga, Karnataka, India.
Revised: 16-04-2014.
Volume 7, Issue 1 · pp. 81–84 · PUBLISHED January-March 2015 · DOI: 10.4103/0974-8490.147213
ABSTRACT
Objective To assess the anthelmintic acivity of Bacillus cereus and Bacillus pumilus metabolites. Materials and Methods The successive solvent extractions with petroleum ether, ethyl acetate and methanol. The solvent extracts were tested for anthelmintic activity against Pheretima posthuma at 20 mg/ml concentration. The time of paralysis and time of death of the worms was determined for all the extracts. Albendazole was taken as a standard reference and sterile water as a control. Results All the sample extracts showed significant anthelmintic activity in paralyzing the worms comparable with that of the standard drug. The time of death exhibited by BP metabolites was close to the time exhibited by standard. Conclusion The study indicates both bacteria Bacillus cereus and Bacillus pumilus have anthelmintic activity indicating potential metabolites in them.
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Kumar, M. L. V., Thippeswamy, B., Kuppust, I. L., Naveenkumar, K. J., & Shivakumar, C. K. (2015). Evaluation of Bacillus cereus and Bacillus pumilus metabolites for anthelmintic activity. Pharmacognosy Research, 7(1), 81–84. https://doi.org/10.4103/0974-8490.147213