Volume 54, Issue 4

Original Article(continued)

1. Article

   Development of Solid Dispersions of Clopidogrel using Innate Excipient: Synergistic Antiplatelet Activity

   Chander Pal Singh Verma, Santosh Verma, Mahendra Singh Ashawat, Vinay Pandit

   pp. 1007–1015 · DOI: 10.5530/ijper.54.4.194 · 2020

   Aim: The present study encompasses on formulation and evaluation of solid dispersion of Clopidogrel, Class II drug-using pectin extracted from mango peel. Materials and Methods: Pectin was extracted from full-grown mango…

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2. Article

   Evaluation of Gelling Behavior of Natural Gums and their Formulation Prospects

   Rachit Mohan, Shobha Singh, Geetendra Kumar, Manjoosha Srivastava

   pp. 1016–1023 · DOI: 10.5530/ijper.54.4.195 · 2020

   Purpose: Gums and polymers can be found abundantly in the nature from various plants, microbial and marine sources. Their physical and functional characteristics can be customized according to its application in product …

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3. Article

   Influence of Ketogenic Diet and Phenytoin Sodium on Isoniazid Induced Epilepsy in Wistar Rats

   Somasundaram Ramachandran, Satya Sravanthi, Sri Ramya Manthena, Undru Liza, Masa Amala

   pp. 1024–1030 · DOI: 10.5530/ijper.54.4.196 · 2020

   Aim: The current research was set up to estimate the influence of ketogenic diet in combination with phenytoin sodium on isoniazid induced epilepsy in rats. Methods: In this work 30 rats were used with weight range of 15…

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4. Article

   In silico Evaluation on the Inhibition Efficacy of Five Antivirals on SARS-CoV-2 Protease (COVID-19)

   Vinod Palayoor Raphael, Shaju Kanimangalath Shanmughan

   pp. 1031–1038 · DOI: 10.5530/ijper.54.4.197 · 2020

   Background: All over the world rigorous research attempts are going on to find a remedy for the spreading and prevention of the dreadful pandemic of 21st century, the Coronavirus Disease (COVID-19). To discover an effect…

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5. Article

   Asarone and Metformin Modulates the Oxidant- Antioxidant Imbalance on Experimentally Induced Hepatocellular Carcinoma during Diabetic Condition

   Bhrigu Kumar Das, Pramod Channabasappa Gadad

   pp. 1039–1045 · DOI: 10.5530/ijper.54.4.198 · 2020

   Aim: The aim of the present study was planned to investigate the efficacy of asarone and metformin HCl as an antioxidant on experimentally induced diabetic-hepatocellular carcinoma (HCC) condition in male Wistar rats. Me…

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6. Article

   Effect of Normosil Probiotic Supplementation on the Growth Performance and Blood Parameters of Broiler Chickens

   Airat Khabirov, Fail Khaziakhmetov, Vyacheslav Kuznetsov, Hamit Tagirov, Maksim Rebezov, Aleksandra Andreyeva, Almaz Basharov, Zhanibek Yessimbekov, Muhammad Ayaz

   pp. 1046–1055 · DOI: 10.5530/ijper.54.4.199 · 2020

   Purpose: This study was aimed to investigate the effects of probiotic “Normosil” containing a mixture of living cultures of Lactobacillus and Enterococcus strains at a concentration of 1×106 and 1×107 CFU/mL was assessed…

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7. Article

   Antiangiogenic Potential of Levetiracetam by Blocking N-type Voltage Gated Calcium Channels

   Chandana Kamili, Hima Sowmya Kandoti, Sunil Kumar Sarolu, Suresh Merugu, Abbulu Konde

   pp. 1056–1061 · DOI: 10.5530/ijper.54.4.200 · 2020

   Objectives: Angiogenesis is generation of micro vessels. These ion channels on endothelium play vital functions in cell proliferation, migration, cell volume expansion and in related angiogenesis. Our study aims to evalu…

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8. Article

   Xanthine Oxidase and Lipid Peroxidation Inhibition of Taiwan Folkloric Medicine Factors Affecting Rhus semialata var. Roxburghiana Activities against Xanthine Oxidase and Ferrous Iron-induced Lipid Peroxidation on Mice Liver Mitochondria

   Po-Wei Tsai, Pei-Chin Lin, Ling-Ling Yang, Ai-Ho Liao, Bo-Cheng Wang, Ming-Shun Wu

   pp. 1062–1071 · DOI: 10.5530/ijper.54.4.201 · 2020

   Background: Gout, a disease characterized by recurrent inflammatory for urate deposit from overactive xanthine oxidase, is common among Taiwanese. Rhus semialata var. roxburghiana (RSR) grows wildly in Central Mountain o…

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9. Article

   Standardization of Trigonella foenum-graecum L. Seeds: A Quality by Design Approach

   Vishakha Parab Gaonkar, Kirankumar Hullatti, Vinodh Mannur

   pp. 1072–1079 · DOI: 10.5530/ijper.54.4.202 · 2020

   Aim: To standardize Trigonella foenum-graecum L. Seeds by developing QbD based HPLC method for identification and quantification of trigonelline in T. foenum graecum L. seeds, along with evaluation of various quality con…

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10. Article

    Evaluation of Hepatoprotective Effect of a Polyherbal Megakutki against Paracetamol-Induced Hepatotoxicity

    Asha Elizabeth Giri, Vanishree Rao, Sandeep Singhal, Karthik Gourishetti, Subhankar Biswas, Krishnadas Nandakumar, Mallikarjuna Rao Chamllamudi, Jeetesh Dave, Rakesh Dave, Suhani Sumalatha, Nitesh Kumar

    pp. 1080–1088 · DOI: 10.5530/ijper.54.4.203 · 2020

    Background: Megakutki® (MK) is a polyherbal preparation of 11 standardized extracts that are individually proven for hepatoprotection scientifically. Aim: Study evaluated MK’s hepatoprotective potential against paracetam…

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11. Article

    Neuroprotective effect of 1, 3-β-glucan-curcumin mixing (Bioglucur) on Alzheimer Disease Induced in Mice by Aluminium Toxicity

    Nesrine Ouda Amari, Noureddine Djebli, Le Mai Huong, Tran Thi Hong Ha, Nguyen Dinh Luyen, Vu Thi Bich

    pp. 1089–1097 · DOI: 10.5530/ijper.54.4.204 · 2020

    Aim: The aim of this study was to evaluate the neuroprotective effect of oral administration of acomplex of curcumin with 1,3-β-glucan extracted from Vietnamese mushrooms named Bioglucur to increase drug delivery efficie…

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12. Article

    HPTLC Fingerprinting: A Tool for Simplified Analysis of Phenolics in Medicinal Plants

    Amit Yadaorao Saraf, Aparna Amit Saraf

    pp. 1098–1103 · DOI: 10.5530/ijper.54.4.205 · 2020

    Background: Phenolic compounds especially the flavonoids and tannins comprise one of the most significant classes of plant secondary metabolites. Aim: HPTLC is widely accepted by WHO and pharmacopoeia across the globe as…

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13. Article

    Phytochemical Investigation, TLC-HPLC Fingerprinting and Antioxidant Activity of Cissus repanda Roots

    SachinBhusari SachinBhusari, KanchanNikam KanchanNikam, BhanudasKuchekar BhanudasKuchekar, PravinWakte PravinWakte

    pp. 1104–1108 · DOI: 10.5530/ijper.54.4.206 · 2020

    Aim: To perform phytochemical screening, TLC, HPLC fingerprinting and antioxidant assay of Aqueous, Aqueous-Ethanolic and 95% Ethanolic extracts of Cissus repanda roots. Methods: Aqueous, Aqueous-Ethanolic and 95% Ethano…

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14. Article

    Antioxidant and Anti-inflammatory Activity Screening of Lasia spinosa Rhizome and its Validation using a Computational Simulation Approach

    Arya Lakshmi Marisetti, Mohan Gandhi Bonthu, Ganga Rao Battu

    pp. 1109–1120 · DOI: 10.5530/ijper.54.4.207 · 2020

    Background: The present work assesses the antioxidant and anti-inflammatory effect of Lasia spinosa rhizome extracts on in-vitro and in-vivo models compiled through molecular docking study of plant-steemed phytocompounds…

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15. Article

    Synthesis, in-silico Studies and Evaluation of Anticancer Activity of Some Novel Benzothiazole Substituted 4-Thiazolidinones

    Chaithra Raju Shetty, Katte Ishwar Bhat, Abhishek Kumar, Pankaj Kumar, Praveen Thaggikuppe Krishnamurthy, Vijay Kumar Merugumolu

    pp. 1121–1132 · DOI: 10.5530/ijper.54.4.208 · 2020

    Background: Cancer is one of the leading diseases associated with the high degree of mortality. In current scenario chemotherapy is the major treatment for cancer and it still has few limitations. The continuous seek for…

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16. Article

    An in-depth Study of the Concept of Chirality in Organic and Pharmaceutical Chemistry: Using Crystal Structure Data with 3D Visualization Software

    Yi Yang, Jian Xu, Gao Cao

    pp. 1133–1143 · DOI: 10.5530/ijper.54.4.209 · 2020

    Background: Chirality is an essential feature of life and a universal phenomenon in nature, chirality in chemistry and biochemistry is closely related to biological, spectroscopic and physical properties. The concept of …

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17. Article

    Novel Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Alfuzosin and Dutasteride in Pharmaceutical Dosage Form

    Keerthana Diyya

    pp. 1144–1152 · DOI: 10.5530/ijper.54.4.210 · 2020

    Aim: The present study was to develop a simple, accurate and stable reverse phase liquid chromatographic method and validate in bulk drug and pharmaceutical dosage form for the simultaneous determination of Alfuzosin Hyd…

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18. Article

    New Method for the in vivo Estimation of Fluvastatin and its Application for Pharmacokinetic Studies in Rabbit

    Deepthi Sandhala, Srinivas Lankalapalli

    pp. 1153–1158 · DOI: 10.5530/ijper.54.4.211 · 2020

    Aim: The study was aimed to conduct a pharmacokinetic evaluation of Fluvastatin in rabbit plasma using a sensitive HPLC method. Materials and Methods: The plasma samples were assayed by Waters alliance e-2695 HPLC instru…

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19. Article

    Development of Validated Stability-indicating RP-HPLC Method for Determination of Novel Directly Acting Antiviral agent and Characterization of its Degradants by LC–ESI–MS

    Babita Agarwal, Santosh Gandhi

    pp. 1159–1168 · DOI: 10.5530/ijper.54.4.212 · 2020

    Aim: The current study was performed to develop and validate stability indicating high performance liquid chromatography method (RP-HPLC) for determination of ledipasvir (LPR); to identify and characterize its major degr…

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20. Article

    Development of HPTLC Method for Estimation of Gallic Acid and Bergenin in Actaea acuminata Roots

    Deepak Kumar, Reecha Madaan, Suresh Kumar

    pp. 1169–1173 · DOI: 10.5530/ijper.54.4.213 · 2020

    Introduction: The major drawback associated with herbal drugs is to get their reproducible therapeutic efficacy. Standardization of herbal drugs with marker compounds seems to be a viable solution to achieve their consis…

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