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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Protective Effect of Plumeria obtusa Leaves Extracts on Dexamethasone-induced Insulin-resistance Diabetes Mellitus in Rats

Sumeet Gupta1★, Hitendra Sharma1, Mohamed Aly Morsy2,3, Anroop Balachandran Nair2, Kamalpreet Kaur1, Satish Kumar1, Meenakshi Dhanawat1★ Corresponding author

  1. 1Department of Pharmacology, MM College of Pharmacy, MM (Deemed to be University), Mullana, Ambala, Haryana, INDIA.
  2. 2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  3. 3Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia, EGYPT.

CORRESPONDENCE

Sumeet Gupta

Department of Pharmacology, MM College of Pharmacy, MM (Deemed to be University), Mullana, Ambala, Haryana, INDIA.

sumeetgupta25@gmail.com

Received: 25-11-2020; Revised: 18-12-2020; Accepted: 21-02-2021.

Volume 55, Issue 1S · pp. S184–S192 · PUBLISHED 2021 · DOI: 10.5530/ijper.55.1s.49

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ABSTRACT

Background: Plumeria obtusa L., a potential medicinal plant, is still unexplored for its anti-diabetic effect. The objective of this study was to examine the protective effect of Plumeria obtusa leaves extracts on insulin-resistance diabetic rat model. Materials and Methods: Male Wistar rats were distributed into twelve groups. Dexamethasone was used to induce insulin-resistance diabetes mellitus. Three different doses of each extract (petroleum ether, ethanol and aqueous) were orally administered for 45 days. Biochemical estimations, as well as histological and scanning electron microscopy examinations, were done on the 45th day. Results: Statistically significant improvement in serum levels of glucose, glycosylated haemoglobin and insulin, as well as lipid profiles, were observed specifically with ethanol and aqueous extracts in comparison to the positive control group. Conclusion: The histological and scanning electronic microscopy studies revealed a significant improvement in various organs. Hence, this plant needs to be explored at the molecular level.

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    Gupta, S., Sharma, H., Morsy, M. A., Nair, A. B., Kaur, K., Kumar, S., & Dhanawat, M. (2021). Protective Effect of Plumeria obtusa Leaves Extracts on Dexamethasone-induced Insulin-resistance Diabetes Mellitus in Rats. Indian Journal of Pharmaceutical Education and Research, 55(1S), S184–S192. https://doi.org/10.5530/ijper.55.1s.49