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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Polyacrylamide Grafted Gum Acacia (GA-g-PAM) Graft Copolymer as Efficient Polymeric Scaffold

Trishna Bal1★, Priyashi Singh1, Aditya Dev Rajora1, Sandeep Garg1, Barnali Dasgupta Ghosh2, Ashok Kumar Pattnaik1★ Corresponding author

  1. 1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, INDIA.
  2. 2Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, INDIA.

CORRESPONDENCE

Trishna Bal

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, INDIA.

trishna.bal@gmail.com

Received: 08-12-2020; Revised: 27-02-2021; Accepted: 12-04-2021.

Volume 55, Issue 2S · pp. s441–s447 · PUBLISHED 2021 · DOI: 10.5530/ijper.55.2s.115

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ABSTRACT

Background: Natural polysaccharides are mostly not stable in their original form but their biodegradable properties can be beneficial for use as polymeric scaffolds for tissue engineering. Microwave irradiation assisted grafting synthesis being an easy and quick method enhances stability of these natural polysaccharides. Materials and Methods: Initially the optimization of the redox initiator ammonium per sulfate (APS) along with the monomer concentration acrylamide (AM) was done by % grafting efficiency (%GE) for getting the optimized grade of graft copolymer (GA-g-PAM). The microwave time was kept constant with the concentration of the polymer Gum acacia (GA). Different analytical techniques were used for the characterization of optimized grade G6 like Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), X-ray diffraction(XRD) and Nuclear magnetic resonance (NMR) which confirmed successful grafting reactions and scanning electron microscopy (SEM) was utilized to analyze the interior architecture as well the cell proliferation on to the polymer surface. The optimized grade G6 was inserted under the skin hypodermis for tissue proliferation. Results: The % grafting efficiency (%GE) of optimized grade of Polyacrylamide grafted Gum acacia (GA) graft copolymer (GA-g-PAM) was 94.54%. Histolology studies of local tissue of the test mice revealed that the polymer material after insertion onto the mice skin enhanced the cell proliferation as there were evidences of more collagen as well as fibroblast growth in test animal local tissue than in comparison to control mice. Conclusion: Thus, results indicate that polyacrylamide grafted gum acacia graft copolymer (GA-g-PAM) is sufficiently biocompatible and suitable as versatile material for tissue engineering purpose.

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    Bal, T., Singh, P., Rajora, A. D., Garg, S., Ghosh, B. D., & Pattnaik, A. K. (2021). Polyacrylamide Grafted Gum Acacia (GA-g-PAM) Graft Copolymer as Efficient Polymeric Scaffold. Indian Journal of Pharmaceutical Education and Research, 55(2S), s441–s447. https://doi.org/10.5530/ijper.55.2s.115