Volume 56, Issue 2

Original Article(continued)

1. Article

   Bioguided Isolation of Alternariol Derivatives from Ficus-derived Endophyte Alternaria alternata

   Randa Abdou, Gouda H Attia, Mariam Mojally, Mohamed Dawoud, Mostafa E Rateb

   pp. 497–502 · DOI: 10.5530/ijper.56.2.71 · 2022

   Background: Endophytes are a rich source of bioactive natural products and suggested to contribute to the biological or defense activities of their host plants. Following our research on the discovery of bioactive metabo…

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2. Article

   Modulation of Oxidative Stress Induced Cerebral Ischemia in Wistar Rats by Hydroalcoholic Extract of Talinum triangulare

   Nalini Mathala, Vijaya Bhaskara Rao, Venkata Deepthi Vemuri, Gollu Gowri, Nalla Swathi, Allam Sasikala

   pp. 503–510 · DOI: 10.5530/ijper.56.2.72 · 2022

   Background: Neuroprotection is one of considerable interest in search of novel therapies to improve ischemic brain damage in the present scenario. The objective of the present investigation is to study the actions of Tal…

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3. Article

   Antitumor and Cytotoxic Protein Component from Aporrectodea longa: Purification, and Characterization Studies

   Faisal Alotaibi

   pp. 511–519 · DOI: 10.5530/ijper.56.2.73 · 2022

   Background: Cancer, a metabolic disorder with multifactorial input, is the most complex human disease to study and find a cure. Over several decades, massive research effort leads to a better understanding molecular biol…

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4. Article

   Anti-inflammatory and Anti-hyperuricemic Effect of Ficus benghalensis Bark Extract in Raw 246.7 Cell Line

   Essa M Sabi, Ahmed H Mujamammi, Khalid M Sumaily, Lotfi S Bin Dahman, Ziyad M Althafar

   pp. 520–528 · DOI: 10.5530/ijper.56.2.74 · 2022

   Background: Hyperuricemia and inflammation are associated with the etiology and pathogenesis of several metabolic diseases. Controlling the elevated levels of uric acid and inflammation can be a potential therapeutic opt…

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5. Article

   Simultaneous Quantification of Syringic Acid and Kaempferol in Methanolic Extract of Cleome viscosa Linn. by Using Validated HPTLC-Densitometric Method

   Urvija Shankar, Vijay Kumar Nirala, Pushpendra Kumar Shukla, Sharad Srivastava

   pp. 529–538 · DOI: 10.5530/ijper.56.2.75 · 2022

   Cleome viscosa Linn. (Capparaceae) commonly known as “Hurhur”, is a traditional medicinal plant used in the treatment of various ailments such as fever, inflammation, liver disorder, ulcer stomachache etc. In the present…

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6. Article

   Determination of Nitazoxanide in Biological Matrices by LC-MS/MS Technique: Method Development and Validation

   Abdul Saleem Mohammad, B Jayanthi

   pp. 539–545 · DOI: 10.5530/ijper.56.2.76 · 2022

   Background: Determination of pharmaceuticals in the biological matrices is essential for toxicologic and pharmacokinetic applications. The main objective of the current work was to develop a bioanalytical method for quan…

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7. Article

   Development of Fast, Precise and Selective RP-HPLC Methods for Identification of Possible Degradation Products of Ivermectin in Isolated Rat Hepatocytes and in Different pH Media

   Alexandrina Dineva, Borislav Angelov, Magdalena Kondeva-Burdina, Maya Georgieva, Alexander Zlatkov

   pp. 546–552 · DOI: 10.5530/ijper.56.2.77 · 2022

   Aim: A new stability indicating RP-HPLC based methods were developed to identify the possible degradation products of Ivermectin in isolated rat hepatocytes and in different pH media using a C18 RP column. Complete valid…

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8. Article

   Design of Experiment Mediated Development of Stability Indicating High Performance Thin Layer Chromatography Method Invoking Failure Mode Effect Analysis Based Risk Assessment in Estimation of Edoxaban Tosylate Monohydrate

   Vrunda Balvantbhai Mistry, Hitika Bharatbhai Patel, Praful Pravinchandra Dedhiya, Kunjan Bharatbhai Bodiwala, Sandesh Rajmal Lodha, Shrikant Vijayrao Joshi, Gajanan Govindrao Kalyankar

   pp. 553–563 · DOI: 10.5530/ijper.56.2.78 · 2022

   Aim: Development of stability indicating high performance thin layer chromatographic method for quantification of edoxaban tosylate monohydrate in its pharmaceutical dosage form using quality by design approach. Methods:…

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9. Article

   Rapid Simultaneous Quantitative Analysis of Hypoglycemic agents by RP HPLC: Development, Validation and Application to Medicine

   Mahesh Attimarad, Katharigatta Narayanaswamy Venugopala, Mohammed Munirul Islam, Sheeba Shafi, Abdulrahman Ibrahim Altaysan

   pp. 564–572 · DOI: 10.5530/ijper.56.2.79 · 2022

   Background: For the treatment of diabetes mellitus type 2, a new formulation containing vildagliptin and remogliflozin was developed. A simple and rapid RP-HPLC method employing linagliptin as an internal standard was de…

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10. Article

    Synthesis of Transition Metal Complexes of Isoniazid Derivatives and Urease Inhibition Activity Detection

    Yi-Heng Zhang, Ze-Yu Fang, Juan Sun, Yuan-Feng Wu

    pp. 573–579 · DOI: 10.5530/ijper.56.2.80 · 2022

    It have been reported that the transition metal complex of Schiff base ligands have the ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes [Cd2(L)2·(H2O)] (1), [Pb(L)·, [Pbe2) wer…

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11. Article

    Protective Effect of the Aqueous Extract of Cyamopsis tetragonoloba Seed against the Paracetamol-induced Toxicity in Female Wistar Albino Rats

    Jerine Peter Simon, Arunraj Namachivayam, RamKumar Katturajan, Sangeetha Nithiyanandam, Manisha Parthasarathy, Evan Prince Sabina

    pp. 580–588 · DOI: 10.5530/ijper.56.2.81 · 2022

    Background: Paracetamol is also known as acetaminophen which is the most widely and commonly used painkiller drug among the overall human population. On excess usage and high dosage, paracetamol can cause liver injury, g…

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12. Article

    In vivo Wound Healing Potential of Raloxifene Nanoemulsion Gel for the Management of Postmenopausal Cutaneous Wounds

    Tej Pratap Singh, Navneet Verma, Farhan Jalees Ahmad, Phool Chandra, Gaurav Kumar Jain

    pp. 589–599 · DOI: 10.5530/ijper.56.2.82 · 2022

    Background: Depletion in estrogen level(s) especially in postmenopausal women is reported to have delayed wound healing effects; hence we have evaluated the wound healing potential of raloxifene in rat model. Objectives:…

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