Volume 56, Issue 2

Saravanan Jayaram, Praveen Thaggikuppe Krishnamurthy, Divakar Selvaraj, Sri Vyshnavi Nemani, Emdormi Rymbai, Deepa Sugumar, Anusha Shreenidhi Bhat, Meghana Joshi, Vishnu Kumar

pp. 321–328 · DOI: 10.5530/ijper.56.2.52 · 2022

Human beings prefer a predictable and certain environment over an unpredictable and uncertain environment. No one predicted the coronavirus pandemic and it is not certain when the pandemic will come to an end. Pandemics …

Shivaji Prataprao Gawade

pp. 329–346 · DOI: 10.5530/ijper.56.2.53 · 2022

The presynaptic autoreceptors and / or presynaptic heteroreceptors of the principal neurotransmitters involved in the release mechanism of neurotransmission have been identified employing various experimental models, bas…

Bhavesh Namdev, Senthil Venkatachalam, N Jawahar, Anushma Chorsiya

pp. 347–355 · DOI: 10.5530/ijper.56.2.54 · 2022

In this review we have elaborated about number of hypothesis postulated to understand the mechanism of hydrotropic agents, although majority of the postulated hypothesis haven’t justified the solubility enhancement mecha…

Guangchun Piao, Zhiyong Li, Ao Wang, Yifei Su, Gao Li, Xuejun Jin, Haidan Yuan

pp. 356–363 · DOI: 10.5530/ijper.56.2.55 · 2022

Objectives: The aim of this study was to investigate the current situation with the undergraduate tutorial system in China from the students’ perspective and to further improve that system for greater developmental benef…

Lan Wang, Dan Shu, Chien Tai Mao, Yi Zhao, Chao AI

pp. 364–371 · DOI: 10.5530/ijper.56.2.56 · 2022

Background: Methotrexate (MTX) is still the gold standard therapy for moderate to severe psoriasis. There is a marked interpersonal variation in the therapeutic response and toxicity profile of MTX which brings difficult…

Nhu Thao Huynh, Quoc Nguyen Cuong, Thanh Men Tran, Tuan Trong Nguyen, Thi Buu Hue Bui, Quang De Tran

pp. 372–386 · DOI: 10.5530/ijper.56.2.57 · 2022

Silicone is a widely-used cosmetic ingredient, whose advantages are perceived as detackification, soft and non-greasy feeling, and excellent spreading quality. Therefore, in this work, we aim to formulate BB cream based …

Swaroop Lahoti, Mukesh Kumar, Sulbha Gaikwad

pp. 387–395 · DOI: 10.5530/ijper.56.2.58 · 2022

Background: Pazopanib is second-generation tyrosinekinase inhibitor used in Colorectal cancer (CRC) which is effective orally. Targeted liposomal drug delivery will reduce the unwanted side effects of the drug. The appli…

JidnyasaPantwalawalkar JidnyasaPantwalawalkar, SopanNangare SopanNangare

pp. 396–404 · DOI: 10.5530/ijper.56.2.59 · 2022

Purpose:The present study was aimed at the formulation of lafutidine-loaded silk fibroinbased floating microspheres (LAFU-SF-Microspheres) for the site-specific sustained release of the drug. Materials and Methods: Brief…

Nusrat B Sayyad, Prafulla M Sabale, Mohit D Umare, Komal K Bajaj

pp. · DOI: 10.5530/ijper.56.2.51 · 2022

Aim: Breast cancer is one of the most common cancers among women, consistently elevated estrogen level in the blood associated with persistently in breast cancer found in many studies. The mechanisms of carcinogenesis wh…

Moreshwar Patil, Diksha Sonawane, Sandeep Sonawane, Deepak Bhambere, Sanjay Kshirsagar

pp. 405–413 · DOI: 10.5530/ijper.56.2.60 · 2022

Background: This study was initiated to develop celecoxib lipospheres to provide controlled release. It demonstrates the use of central composite design for optimization of liposphere formulation with less number of expe…

Mallikarjun Telsang, Pradeep D, Wilson B, Vasia Tamreen, Shaik Sadik, Mohammed Habeebuddin, Afzal Haq Asif, Mohammed Basheeruddin Asdaq, Sree Harsha Nagaraja, Syed Dawood Noor

pp. 414–419 · DOI: 10.5530/ijper.56.2.61 · 2022

Background: Bendamustine-loaded albumin nanoparticles were prepared using different concentrations of Bovine Serum Albumin (BSA) with the goal of delivering the medication to particular cancer cells. Materials and Proced…

Pradnya Salunkhe, Prashant B Gurav, Vipul Sansare, Sujit Nagare

pp. 420–428 · DOI: 10.5530/ijper.56.2.62 · 2022

Objectives: The objective of present study was to improve dissolution rate with tableting properties of BCS class II drug Etodolac, by melt granulation and sublimation techniques. Materials and Methods: The granules of e…

Shabari Girinath Kala, Santhivardhan Chinni

pp. 429–437 · DOI: 10.5530/ijper.56.2.63 · 2022

Aim: The purpose of this study was to investigate the comparative drug release kinetics of implants and microspheres of an anticancer drug loaded onto a bio-degradable polymer. Methods: Poly (sebacic anhydride) was synth…

Pravin Kumar Dakshinamurthy, Kodiveri Muthukaliannan Gothandam

pp. 438–447 · DOI: 10.5530/ijper.56.2.64 · 2022

Background: Biosimilars to monoclonal antibodies were developed to increase the accessibility of this drug and reduce the costs of this therapy without compromising on its quality, safety, and efficacy. The objective of …

Qi Yuan, Jia Feng

pp. 448–454 · DOI: 10.5530/ijper.56.2.65 · 2022

Background: Octreotide is a somatostatin analogue and it produces beneficial effects in diabetic-neuropathy. Studies have also shown its beneficial role in Alzheimer disease. However, the role of octreotide in diabetes-i…

Agnes B Alimboyoguen, Kathlia A De Castro-Cruz, Evangelina M Fidel, Chien-Chang Shen, Po-Wei Tsai

pp. 455–460 · DOI: 10.5530/ijper.56.2.66 · 2022

Background: This study describes the isolation of chemical constituents from the leaves and bark of Phyllanthus acidus, a medicinal plant widely used for the treatment of several ailments. Materials and Methods: The crud…

Tu Nguyen, Vinh Doan, Anh Nguyen

pp. 461–469 · DOI: 10.5530/ijper.56.2.67 · 2022

Aim: Finding out the biological sources is essential for pharmaceutical field. Materials and Methods: Endophytic fungus was isolated from Catharanthus roseus originated in Vietnam and then identified by comparing, phylog…

Mohini Upadhye, Uday Deokate, Rohini Pujari, Mohini Phanse

pp. 470–478 · DOI: 10.5530/ijper.56.2.68 · 2022

Background: The data presented in this article for Ficus glomerata Linn. belonging to family Moraceace which is commonly found all over India. This study aimed towards the development and validation of high-performance t…

Sri Rashmy Madathil, Poornima Kannappan, Sridhar Muthusami, Perumalsamy Muneeswari, Loganayaki Periyasamy

pp. 479–488 · DOI: 10.5530/ijper.56.2.69 · 2022

Background: Colorectal Cancer, (CRC) ranks third among global cancer incidence statistics and occupies fourth position as far as cancer related death is concerned and the aim of the study is to evaluate the therapeutic p…

Naeem Ullah Jan, Muhammad Kifayatullah, Fazli Amin, Haroon Rahim, Sudhair Abbas, Syed Nadeem Ul Hassan Mohani, Salman Aman, Muslim Raza

pp. 489–496 · DOI: 10.5530/ijper.56.2.70 · 2022

Background and Objectives:Cancer is believed to be one of the main challenges to health care profession and compounds isolated from natural products play significant role in treatment of cancer. Sarcococca saligna (Buxac…