Volume 56, Issue 4

Original Article(continued)

1. Article

   The Inhibition Effect of 2-Methoxy-1,4- naphthoquinone on Human Hepatoma Cell Lines: A in vitro and in vivo Studies

   Huaguo Liang, Ying Wen, Wei Fang, Xiaoyan Cai, Xiangsheng Wang, Li Zou, Peng Wei, Baoyun Yang, Jiazheng Lu, Yongxia Yang, Yongli Zhang

   pp. 1106–1114 · DOI: 10.5530/ijper.56.4.192 · 2022

   Background and Aim:To study the antitumor activity of 2-Methoxy-1,4-naphthoquinone (MNQ) against hepatocellular carcinoma (HCC) cells, in an attempt to fill the knowledge gap of anti-liver cancer with MNQ. Materials and …

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2. Article

   Discovery of Potential Inhibitors of Mycobacterium tuberculosis EthR Using Structure and Ligand Based in silico Approaches

   Bandar Hamad Aloufi, Ahmed Mohajja Alshammari

   pp. 1115–1122 · DOI: 10.5530/ijper.56.4.193 · 2022

   Aim and Background: Mycobacterium tuberculosis (TB) remains the leading cause of human death posing one of the most serious threats to public health around the world. New strategies need to be developed to combat the gro…

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3. Article

   Amelioration of Hepato-renal Impairment by Natural Chelators in Lead-induced Poisoning in Rats

   Quadri Neha Nausheen, Syed Ayaz Ali, Shoaeb Mohammad Syed, Tarannum Rashid Patave

   pp. 1123–1133 · DOI: 10.5530/ijper.56.4.194 · 2022

   Background: Hepato-Renal impairment refers to renal dysfunction in a liver compromised state concerning lead metal exposure. Natural chelators (marine source) have potent chelating properties claiming to ameliorate hepat…

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4. Article

   Detection of Novel Candidate Mutations as a Cause of Steroid-resistant Nephrotic Syndrome in Children Using Next-generation Sequencing Techniques

   Walaa F. Alsanie, Abdulhakeem S. Alamri, Turki M. Sobahy, Samar A. Zailaie, Majid Alhomrani, Moamen S. Refat, Hamza Habeeballah, Syed Mohammed Basheeruddin Asdaq, Nagaraja Sreeharsha, Ahmed Gaber

   pp. 1134–1140 · DOI: 10.5530/ijper.56.4.171 · 2022

   Background and Objectives:Steroid-resistant nephrotic syndrome (SRNS) is a serious chronic ailment that affects children and causes blood coagulation issues as well as an increased vulnerability to infections. Only aroun…

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5. Article

   Evaluation of Anti-cancer Activities of Cranberries Juice Concentrate in Osteosarcoma Cell Lines (MG-63)

   Aishwarya Hattiholi, Shivani Tendulkar, Vijay Kumbar, Malleswara Rao, Manohar Kugaji, Uday Muddapur, Kishore Bhat

   pp. 1141–1149 · DOI: 10.5530/ijper.56.4.195 · 2022

   Aim/Background: Osteosarcoma is one of the prevalent cancers occurring mostly in adolescents and has a high risk of malignancy. With complications involved in the current treatment strategies, alternates including the us…

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6. Article

   Proteomic Approach Reveals the Activation of Apoptosis by Padina gymnospora in Oral Cancer Cell Line

   Yanyuan Shi, Zhaori Getu

   pp. 1150–1155 · DOI: 10.5530/ijper.56.4.196 · 2022

   Aim/Background: Cancer is still known to be a devastating disease condition. Even after getting advancements in multimodality therapies, the success rate with respect to patient survival is very limited. Hence there is a…

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7. Article

   Anti-diabetic Effect of Sprouted Trigonella foenumgraecum L. Seed Solid Dosage Form in Low-dose Streptozotocin Induced Diabetic Rats

   Ashwini Kumar Mishra, Pravat Kumar Sahoo, Ganesh Lal, Meenakshi Bajpai, Hitesh Kumar Dewangan

   pp. 1156–1163 · DOI: 10.5530/ijper.56.4.197 · 2022

   Background: Trigonella foenum-graecum L (Fenugreek) is an annual herb, mainly cultivated for its seed as well as for its sprouts. Pharmacological investigations reported anti-bacterial, anti-diabetic, anti-cancer, anti-d…

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8. Article

   Evaluation of Methanolic Extract of Polyherbal Cream on DNCB-induced Atopic Dermatitis in Wistar Albino Rats

   G Sivakumar, Cerin Mareena Philip

   pp. 1164–1171 · DOI: 10.5530/ijper.56.4.198 · 2022

   Background: Atopic dermatitis, is a multifactorial chronic inflammatory and immunological disease affecting the skin, with the serious impact on psychological and life style of the patients. Unique polyherbal combination…

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9. Article

   Adhatoda vasica Possesses Anti-microbial Activity and Effectively Ameliorates Ischemia Reperfusion Injury Induced by Doxorubicin through Controlling Oxidative Stress

   Almonther Abdullah Hershan, Ahmed A Abdulhaq

   pp. 1172–1180 · DOI: 10.5530/ijper.56.4.199 · 2022

   Background and Objectives: Myocardial ischemia is one of the leading causes deaths among cardiac pathological conditions. Doxorubicin belongs to anthracycline class of drug which is effective against a wide variety of ne…

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10. Article

    Evaluation of the Thrombolytic and Antioxidant Activity of Leaf Extracts of Plumbago zeylanica L.

    Sarvan Kumar Guguloth, Narender Malothu, D.S.N.B.K Prasanth, Anka Rao Areti

    pp. 1181–1189 · DOI: 10.5530/ijper.56.4.200 · 2022

    Background: Plumbago zeylanica L. is one of the extremely accessible conventionally used herbal plants with various biological activities. However, actions of P. zeylanica L on blood clotting and other complications of b…

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11. Article

    Bio-analytical Method Development and Validation for Simultaneous Determination of Bictegravir, Emtricitabine, and Tenofovir Alafenamide Fumarate in Human Plasma by LC-MS/MS

    Attaluri Tanuja, Seru Ganapaty

    pp. 1190–1205 · DOI: 10.5530/ijper.56.4.201 · 2022

    Aim: The current method was developed as a novel and reliable quantitative liquid chromatography-mass (tandem) spectrometry (LC-MS/MS) method for the estimation of analytes like Bictegravir (BIC) Tenofovir Alafenamide Fu…

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12. Article

    Development and Validation of a Stability-indicating Method for Neostigmine Bromide: Separation, Identification and Characterization of Degradation Product using LC-MS and ESI-Q-TOF-MS/MS

    Rajan Makkar, Jitender Singh, Monika Bhardwaj, Lovekesh Mehta, Parul Grover

    pp. 1206–1218 · DOI: 10.5530/ijper.56.4.202 · 2022

    Objectives: Forced degradation study of the drug product and drug substance is very much important in drug development and drug discovery to establish the intrinsic stability and understand its behaviors towards differen…

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13. Article

    Evaluation of pH Dependent Solubility and Examination of Variation in Pharmacokinetic Properties of Alectinib: A Quantitative Study by Implementing Integrated Quality by Design Approach for RP-HPLC Method Development and Optimization

    Durga Deepthi Kolasani, Mrunal Desai, Prajakta Patil, Jagadish Puralae Channabasavaiah

    pp. 1219–1225 · DOI: 10.5530/ijper.56.4.203 · 2022

    Introduction: Alectinib, an anaplastic lymphoma kinase inhibitor of BCS class IV, is said to have pH-dependent solubility and is susceptible to interactions with co-prescribed acid-reducing agents. Objectives: A micro-di…

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14. Article

    The Prevalence of Anemia and Hematological Findings in COVID-19 Patients in Saudi Arabia

    Mazen Almehmadi, Magdi Salih, Ayman Al-hazmi, Muhannad Alenazi, Osama Abdulaziz, Faisal Almalki, Alaa Shafie, Naif Alsiwiehri, Mamdouh Allahyani, Njoud Althibity, Ebtisam Alosimi, Abdullah Turjoman, Fatimah Rebh, Abdulelah Aljuaid, Mustafa Halawi

    pp. 1226–1231 · DOI: 10.5530/ijper.56.4.204 · 2022

    Objectives: The aim of this study was to estimate the prevalence of anemia among COVID-19 patients in Saudi Arabia and evaluate their hematological parameters. Materials and Methods: A descriptive, cross-sectional, hospi…

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15. Article

    Evaluation of Health-related Quality of Life among Hypertensive Post-menopausal Women Using EQ-5D in India During COVID-19 Pandemic

    Thangamani Subramani, Saravanan Kunchithapatham, Sajeeth Chadappully Ismail

    pp. 1232–1239 · DOI: 10.5530/ijper.56.4.205 · 2022

    Background: Hypertension and menopause are interrelated factors to determine the quality of life (QOL) in women. Covid-19 was related to massive public anxiety, it is critical to know the level of influence in such pande…

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16. Article

    Attributes of Private Pharmacy School Graduates as Care Providers: A Cross-sectional Study from Saudi Arabia

    Saleh Fahad Alqifari

    pp. 1240–1244 · DOI: 10.5530/ijper.56.4.206 · 2022

    Objectives: This study aimed to measure the level of preparedness of recent pharmacy program graduates to deliver patient care. Materials and Methods: A cross-sectional study was conducted using a validated self-administ…

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17. Article

    Garlic Mediated Green Synthesis of Silver Nanoparticles as Antifungal Agents against Magnaporthe oryzae

    Bahareh Bakhshi, Sudhakar Malla, Lokesh Siddalinge Gowda

    pp. 1245–1252 · DOI: 10.5530/ijper.56.4.207 · 2022

    Background: Plant elements such as carbohydrates, lipids, flavonoids, polyphenols, enzymes, terpenoids, and alkaloids are used as reducing substance in the green production of silver nanoparticles. The strategy proved to…

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