Volume 58, Issue 4

2024 · pp. 1007–1379 · 36 articles

Volume: 58
Issue: 4
Published: 2024
Pages: 1007–1379
Articles: 36
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

In this issue

1–20 of 36

Review Article

Review
Efficacy and Safety of Erythromycin in the Treatment of Mycoplasma Pneumonia in Children: A Systematic Review and Meta-Analysis
Mingxiu Sun, Zhirui Xue, Jiarui Li, Likun Du
pp. 1007–1014 · DOI: 10.5530/ijper.58.4.113 · 2024
Aim The effectiveness and safety of erythromycin for treating mycoplasma pneumonia in pediatric patients is a subject of significant interest. This study aims to conduct a systematic review and meta-analysis to assess th…
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Review
From Risk to Resilience: Uncovering Drug Recall Trends and Bolstering Safety Strategies
Venkateswara Raju Kalidindi, Bandaru Mani Sai Durga, Lakshmi Prasanthi Nori
pp. 1015–1033 · DOI: 10.5530/ijper.58.4.114 · 2024
The process of officially calling something back to its original or initial location is termed as “recall.” Pharmaceutical recalls involve requesting to get back a product after it leaves the manufacturer to reach the di…
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Review
Plant Bioactive Compounds: Crucial Pharmacological Properties and Role of Elicitors in Enhancing Production
Durga Anusha Sampath Kumar, Deepa Sankar Parasurama
pp. 1034–1044 · DOI: 10.5530/ijper.58.4.115 · 2024
Plant secondary metabolites play a vital role in developing numerous industrial products. Nutritive products developed from natural sources have better acceptance and demand than chemically synthesized products. Biologic…
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Review
Standards of Child Resistant Packaging: A Regulatory View
Gowthami Kodlahalli Ravindra, Bhoopathi Subramaniam, Balamuralidhara Veeranna
pp. 1045–1053 · DOI: 10.5530/ijper.58.4.116 · 2024
Aim Special packaging known as “child-resistant packaging” is intended to minimize the possibility of kids eating harmful substances. The Poison Prevention Packaging Act of 1970 confers jurisdiction to regulate this on t…
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Review
Research Progress in Mechanisms of Drug-Resistance of Macrolide Antibiotics Resistance in Mycoplasma pneumoniae
Meixuan Jia, Qingtao Li, Lijun Zhang, Xiaona Qian, Liyuan Tian, Zhihui Yan
pp. 1054–1069 · DOI: 10.5530/ijper.58.4.117 · 2024
Aim/Background This review aims to enhance understanding of Mycoplasma pneumoniae (MP) infection and Macrolide-Resistant Mycoplasma pneumoniae (MRMP) pneumonia, emphasizing their epidemiological characteristics and resis…
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Review
Antibacterial Effects of Bioactive Boswellic Acids Loaded Chitosan Nanoparticles against Gram-Positive and Gram-Negative Bacteria
Neeta Rathi, Satyender Kumar, Seema, Harish Dureja
pp. 1189–1197 · DOI: 10.5530/ijper.58.4.131 · 2024
Background: Boswellic acids are naturally occurring pentacyclic terpenoids that have revealed valuable anti-inflammatory, antiproliferation and anticancerous activities. Instead of these effects boswellic acids also poss…
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Review
Development and Characterization of Liquisolid Compact to Improve Dissolution of an Antihypertensive Drug
Arvinder Kaur, Sachin Verma, Deepa Bagur Paramesh, Nawaz Mahammad
pp. 1198–1204 · DOI: 10.5530/ijper.58.4.132 · 2024
Background: The goal of the current research was to use the straight forward, scalable, and economical Liquisolid compact to improve the dissolution profile of the poorly soluble medication Ramipril. Objectives: Utilisin…
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Review
Design, Optimization, and in vitro Evaluation of Orally Disintegrating Tablets Containing Amlodipine Besylate
Sevinç Şahbaz, Setenay Özer-Önder, Timuçin Uğurlu
pp. 1205–1214 · DOI: 10.5530/ijper.58.4.133 · 2024
Background: In this study, it was aimed to prepare orally disintegrating tablet formulations of amlodipine besylate by applying the experimental design. Materials and Methods: A face-centered, central composite 32 full f…
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Review
Formulation of Pregabalin-Loaded Trimethyl Chitosan Microspheres for Nasal Drug Delivery: In vitro, ex vivo and in vivo Characterization
Sonwane Priyanka, Qutub Mohammad, Umekar Milind, Taksande Jayshree
pp. 1215–1224 · DOI: 10.5530/ijper.58.4.134 · 2024
Background: Polar drugs make it difficult to cross nasal cells. Trimethyl Chitosan (TMC) microspheres help absorption by opening junctions, increasing drug retention. Pregabalin absorbs well orally but delays crossing th…
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Review
Synthesis, Anti-inflammatory and in silico Studies of few novel 1,2,4-Triazole Derived Schiff Base Compounds
Deepanshu Vishwakarma, Surya Prakash Gupta
pp. 1235–1241 · DOI: 10.5530/ijper.58.4.136 · 2024
Background: Every year more than 1 billion prescriptions are written for all NSAIDs and yet the quest to develop new NSAIDs remains prominent. Objectives: The current investigation's goal was to synthesize and assess the…
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Review
Coumarin-1,2,3-Triazole Hybrids as Promising Antibacterial Agents: In silico Molecular Docking, ADMET and Molecular Dynamics Simulation Studies (Exploring in silico Antibacterial Potential of Coumarin-1,2,3-triazoles)
Krishna Narayan Mishra, Mayank Rashmi, Harish Chandra Upadhyay
pp. 1242–1254 · DOI: 10.5530/ijper.58.4.137 · 2024
Background: A lot of coumarin-1,2,3-triazole hybrids have been reported to show antibacterial activities, but most of them are unexplored in clinical studies. Herein, we wish to apply in silico docking, physiochemical pr…
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Review
A Simultaneous Quantification of Four Potential Genotoxic Impurities Purinediol Hydrochloride, N7-Isomer, Monoalkyl Contaminant and Diacetyl Purine Present in Penciclovir Using LC-MS/MS
Nagasurendra Reddy Varampati, Devanna Nayakanti
pp. 1255–1266 · DOI: 10.5530/ijper.58.4.138 · 2024
Background: Penciclovir is a medication for antiviral therapy for curing different kinds of herpes virus infections. The four contaminants are the starting materials of Penciclovir which are present at a trace level in t…
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Review
Electrometric Study on Nature and Stability of CoII, NiII and CuII Complexes with 5-Sulfosalicylic Acid in DMSO-Water Mixtures
Malla Balakrishna
pp. 1267–1276 · DOI: 10.5530/ijper.58.4.139 · 2024
Background: The bioavailability of an element and its toxicity based on its chemical species. According to IUPAC the concept of chemical speciation is defined as it is a form of an element according to its oxidation stat…
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Review
HR-LCMS Metabolite Profiling and in silico Evaluation of the Antidiabetic Activity of Methanolic Leaf Extract of Chrozophora rottleri (Geiseler) A. Juss. Ex Spreng.
Srilakshmi Nallapaty, Narender Malothu, Sathish Kumar Konidala, Anka Rao Areti, Chakravarthi Guntupalli
pp. 1277–1286 · DOI: 10.5530/ijper.58.4.140 · 2024
Background: Chrozophora rottleri (Geiseler) A. Juss. ex Spreng. is a well-known traditional medicinal plant with a complex biological profile, though inadequate research has been established on its possible anti-diabetic…
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Review
GCMS and LCMS/MS Based Analysis for the Identification and Characterization of Bioactive Metabolites of Seaweed Kappaphycus striatus as an Anti-hypertensive and Anti-hypercholesterolemic Agent
Hannis Fadzillah Mohsin, Zolkapli Eshak, Sadia Sultan, Wasim Ahmad, Mohammad Humayoon Amini, Kamran Ashraf
pp. 1287–1298 · DOI: 10.5530/ijper.58.4.141 · 2024
Background: Over 50% of the population in Malaysia has hypercholesterolemia, which puts them at a high risk of cardiovascular disease. Both food sources and the ingredients in traditional medications are essential to the…
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Review
Development and Validation of a New RP-HPLC Method for the Simultaneous Estimation of Nirmatrelvir, Ritonavir and Molnupiravir in Formulated Nanosponges, Plasma Samples and its Pharmacokinetic Study
Vyshali Veerareddy, Kumaraswamy Gandla
pp. 1299–1310 · DOI: 10.5530/ijper.58.4.142 · 2024
Background: Nirmatrelvir and Ritonavir are used in combination (Paxlovid®) in order to treat COVID-19. Thus, the goal of the current study was to create an easy-to-use, accurate, and sensitive method for the preparation …
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Review
A Cross-Sectional Study of Community Attitude towards Herbal Products against Hepatobiliary Diseases in Northern Cyprus
Umut Sõzüõz, Azmi Hanoğlu, Fehmi Burak Alkaş, Duygu Yiğit Hanoğlu, Ali Hikmet Meriçli, Dudu Őzkum Yavuz
pp. 1311–1317 · DOI: 10.5530/ijper.58.4.112 · 2024
Aim: The study in Northern Cyprus aimed to improve patient-centered care and healthcare practices by examining community perceptions of Herbal Products (HPs) for liver and biliary diseases. Materials and Methods: The sel…
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Review
Evaluation of the Knowledge, Opinion, and Approaches of Pharmacists, Physicians, Dieticians, and the Public on Herbal Products Used for Weight Control and Slimming in Northern Cyprus
Bariş Şendal lzzet, Hasan Ulaş Yavuz, Dudu Özkum Yavuz
pp. 1318–1327 · DOI: 10.5530/ijper.58.4.111 · 2024
Background: This study explores the perspectives of Northern Cyprus (NC) pharmacists, physicians, dieticians, and the public regarding Herbal Products (HP) for Weight Control (WC) and slimming, contributing valuable insi…
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Review
A Prospective Observational Study on Assessment of Risk Factors, Complications and Clinical Efficacy of Hepatoprotectives and Antimicrobials in Treatment of Liver Diseases at Tertiary Care Teaching Hospital in Telangana
Jaya Sollu, Mounika Pulusu, Deepthi Peddaramamolla, Jharna Islam, Nikhil Soma, Chinnaeswaraiah Maram
pp. 1328–1335 · DOI: 10.5530/ijper.58.4.143 · 2024
Background: The liver serves a variety of essential purposes, making it the most important organ. Chronic liver disease (CLD) has a wide range of etiologies, including toxins, alcoholism, infections, autoimmune illnesses…
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Review
Augmented Optical Retention and Improved Antibacterial Activity against Conjunctivitis of Moxifloxacin Hydrochloride Entrapped in Microsponges in situ Gel: Formulation Evaluation and in vivo Remedial Value in Rabbits
Sangeet Kumar Sharma, Ishab Kumar, Ankur Rohilla, Ramchander Khatri, Tanuj Hooda, Seema Rohilla
pp. 1336–1347 · DOI: u10.5530/ijper.58.4.144 · 2024
Objectives: Moxifloxacin hydrochloride is an antibiotic related to flouroquinolones class. It possessed reasonable to exceptional efficacy against gram-negative ocular pathogens. The prime goal of this study was to formu…
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