Volume 58, Issue 4

Xing Gao, Ziying Liang, Yanan Yuan, Wenbo Liu

pp. 1348–1355 · DOI: 10.5530/ijper.58.4.145 · 2024

Aim/Background: Cervical cancer is a common gynecologic malignant tumor, its occurrence and development are related to genetic and environmental factors. Recent studies have shown that Programmed Cell Death 4 (PDCD4) and…

Zia ur Rehman

pp. 1356–1372 · DOI: 10.5530/ijper.58.4.146 · 2024

Background: Developing effective antimalarial medications requires understanding the interactions between Plasmodium Dihydroorotate dehydrogenase (DHOdehase) and Artemisinin, including its fourteen stereoisomers (R/S) wh…

Xiaoyuan Zhuang, Yatian Wang, Shen Lin, Guoshan Zhang

pp. 1070–1076 · DOI: 10.5530/ijper.58.4.118 · 2024

Background The desire for novel drugs and bioactive ingredients to combat serious illnesses like cancer has grown dramatically. A great deal of research is being done to discover and create new medications. Aim According…

Zhijun Dong, Shujiang Dong, Jiang Li, Yanli Zhu, Zhiyong Ma, Yupei Hou, Weidong Zhao

pp. 1077–1083 · DOI: 10.5530/ijper.58.4.119 · 2024

Objectives To explore the curative effect of QihaPingchuan Capsule combined with triple therapy [Inhaled Corticosteroid (ICS)+Long-Acting β2 receptor Agonist (LABA)+Long-Acting Anticholinergic drug (LAMA)] on Chronic Obs…

Qihui Yuan, Tingxuan Chen, Qing Yang, Zongming Zhang

pp. 1084–1101 · DOI: 10.5530/ijper.58.4.120 · 2024

This study meticulously delineates the research progression, focal points, developmental path and emergent evolutionary trajectories of computational intelligence within the domain of ethics. A comprehensive quantitative…

T Lakshmi Narayanan, Dithu Thekkekkara, Manasa Renu Srivalli Chattu, Amrita Babu, Sreenivasulu Naidu Kondaveeti, SK. Meheroonisha, Thummuru Ekshita Sai

pp. 1102–1109 · DOI: 10.5530/ijper.58.4.121 · 2024

Background Cholesterol synthesized in astrocytes of the cerebrum plays a pivotal role in regulating hippocampal neurogenesis and cognitive function. Dysregulation of cholesterol metabolism has emerged as a key contributo…

Yanping Li, Suresh Kumar, Lihu Zhang

pp. 1110–1120 · DOI: 10.5530/ijper.58.4.122 · 2024

Background Klebsiella pneumoniae, a Gram-negative bacterium, is an established nosocomial pathogen that is particularly dangerous to immunosuppressed individuals, causing diseases such as sepsis, pneumonia, urinary tract…

Basiouny El-Gamal, Thoraya A-Elgadir, Ayyub Ali Patel, Mohamed Abd Ellatif, Khalid Ali Nasif, Awad Saeed Alsamghan, Arshi Malik, Mohamed Babiker Abd Elrouf, Imad Alghawanmeh, Marwa Saeed, Osama Haroun Ahmed, Soha Makki, Haitham Elshaikh, Yasser Ali

pp. 1117–1129 · DOI: 10.5530/ijper.58.4.123 · 2024

Background CDK4 play a pivotal role in cell cycle regulation, making it a critical players in the development and progression of cancer. In recent years, there has been a growing interest in targeting CDK4 for cancer the…

Mikhil Santosh Kore, Angel Pavalu Godad, Gaurav Mahesh Doshi

pp. 1130–1138 · DOI: 10.5530/ijper.58.4.124 · 2024

Background To develop a new drug approach, it is necessary to understand possible ways by which suppression of depressive symptoms can be achieved at the biochemical level. One such protein, which can help relieve depres…

Lin Li, Qian Wang, Yan Gao, Li Zhang

pp. 1139–1147 · DOI: 10.5530/ijper.58.4.125 · 2024

Background Diabetic Nephropathy (DN) is one of the serious complications associated with a prolonged diabetic condition. DN continues to be the primary cause of morbidity and mortality among diabetic patients globally. O…

Zubair Khan, Nazia Siddiqui, Garima Agarwal, Anurag Chaudhary, Syed Salman Ali, Abdel-Nasser El-Shorbagi, Sachin Chaudhary, Prabhash Nath Tripathi

pp. 1149–1156 · DOI: 10.5530/ijper.58.4.126 · 2024

Background Atherosclerosis is a complex progressive pathological process that produces lesions in the inner wall of an artery because of the abnormal lipid metabolism, and dysregulation of inflammatory processes. Increas…

Padmalatha Ajith, SB Prabha

pp. 1157–1166 · DOI: IndJPhaEdRes-58-4-1157 · 2024

Background The extract of Terminalia chebula was explored with a new perspective to control tomato bacterial wilt, opening up a new way in agriculture to control plant disease in an organic way with less impact on the en…

Asma Halmoune, Nadia Salhi, EL Finou Hamza, Ait Benlabchir Abdessamad, Khfif Khalid, Zaid Abdelhamid, El Rhaffari Ihoussaine

pp. 1167–1173 · DOI: 10.5530/ijper.58.4.128 · 2024

Introduction The domestication of Satureja calamintha, either because of its superior tolerance to disease and environmental factors or because of its potential for larger quantities of useful chemicals. Materials and Me…

Yasmina Moumen, Hichem Khammar, Cherif Abdennour, Yacine Zerouki, Meriem Zitouni

pp. 1174–1183 · DOI: 10.5530/ijper.58.4.129 · 2024

Background Medicinal plants are generally considered beneficial to health because they contain secondary metabolites responsible for their therapeutic effects. However, some plants used in phytotherapy are toxic due to t…

Vidya Sabale, Manasi Jiwankar, Prafulla Sabale

pp. 1184–1188 · DOI: 10.5530/ijper.58.4.130 · 2024

Background Prostate cancer is the leading cause of death in men over the age of 50, making it one of the most common cancers. Current treatments available such as chemotherapy, surgery are associated with many side-effec…

Mohammad Raghibul Hasan, Ali Hazazi, Ahad Amer Alsaiari, Fawaz M. Almufarriji, Amirah Albaqami, Osama Abdulaziz, Marwa K Darwish, Atul Kumar, Kapil Dev, Mohammed Ageeli Hakami

pp. 1373–1379 · DOI: 10.5530/ijper.58.4.147 · 2024

Introduction Sophoridine, an alkaloid compound which is isolated from various plant species like Sophoraalopecuroides and Sophora flavescens. It identified to have potential pharmacological properties, including anti-inf…