Volume 17, Issue 1

Original Article(continued)

1. Article

   Molecular Cytocompatibility and Morphomorphometric Analysis of a Sesamum indicum-Rubus idaeus Herbal Gel on 3T3-L1 Fibroblast Architecture

   Ramalingam Gomathi, Thirupambaram Nataraja Sundaram Uma Maheswari, Shanmugam Rajesh Kumar

   pp. 232–237 · DOI: 10.5530/ijpi.20270007 · 2027

   Background: Chronic inflammation and oxidative stress lead to tissue damage, resulting in heightened interest in plant-based therapeutics with low toxicity. Sesame and raspberry contain bioactive compounds that are both …

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2. Article

   Isolation, Characterization and Evaluation of Antidepressant activity of Peonidin-3-O-β-Galactopyranoside from Saraca asoca (Roxb.), De. Willd Leaves

   Sonika Shrivastav, Kamal Singh Rathore, Dinesh Kumar Yadav, Phool Chandra, Arvind Raghav, Neetu Sachan

   pp. 238–248 · DOI: 10.5530/ijpi.20270015 · 2027

   Background: Major depressive disorder is a heterogeneous disease that primarily contributes to global disability. In this condition, individuals often experience disturbances in sleep patterns and psychomotor functions, …

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3. Article

   Comprehensive HPTLC Fingerprinting and Quality Evaluation of Punicalagin in Pomegranate (Punica granatum L.) Aril Juice

   Reddy Prasad Chowdareddy, Thirunavukkarasu Jayaraman, Afzal Khan AK, Mohanakrishna Ghanta, Bibi Umeza

   pp. 249–255 · DOI: 10.5530/ijpi.20270024 · 2027

   Objectives: Pomegranate (Punica granatum) is a well-known source of bioactive phytochemicals, particularly punicalagin, which contributes to its antioxidant, anti-inflammatory, and antimicrobial properties. Materials and…

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4. Article

   Preparation of Multi Unit Rapid Disintegrating Controlled Release (RDCR) Granules by Wet Granulation Using Fluidized Bed Drying for Chronotherapeutic Drug Delivery System for Valsartan

   Jitendra Kantilal Chordiya, Ujashkumar Shah, Nidhi Shah

   pp. 256–268 · DOI: 10.5530/ijpi.20270050 · 2026

   Background: The Multi unit-controlled release dosage forms is a drug delivery system offering advantage over traditional monolithic controlled release system in achieving persistent and predictable drug delivery. Multipl…

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5. Article

   Elucidating the Medhya Role of Lashuna (Allium sativum L) Through in Silico Method with Special Reference to Alzheimer’s Disease

   Jigneshkumar Varu, Pradeep Shahajirao Shindhe, Ramesh Shivappa Killedar, Aniket Ughade

   pp. 269–275 · DOI: 10.5530/ijpi.20270060 · 2026

   Introduction: In Ayurveda, Allium sativum (Lashuna) has been described in great detail as a Medhya medication that may improve cognitive function. The current study used molecular docking and in silico network pharmacolo…

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6. Article

   Effect of Fenugreek Seed Extract against Induced Cognitive Decline in Experimental Mice

   Shalam Mohamed Hussain, Nayef Almutairi, Fahad Alrakaf, Mohammed Aljameli

   pp. 276–282 · DOI: 10.5530/ijpi.20270064 · 2026

   Background: Alzheimer’s disease affecting about 18 million people world-wide. The socio-economic burden on world-economies costing more than 172 billion US $ annually for the US alone. Objectives: To prepare aqueous extr…

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7. Article

   In silico SAR-Guided Discovery of Imidazole-Based Anticonvulsants with Optimized ADMET Profiles

   Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju

   pp. 283–291 · DOI: 10.5530/ijpi.20270083 · 2026

   Background: Epilepsy is a chronic neurological disorder characterized by recurrent seizures caused by abnormal electrical activity in the brain. The development of novel anticonvulsant agents with improved efficacy and s…

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8. Article

   Evaluation of Antioxidant, Antimicrobial and Cytotoxic Activities of Endemic Verbascum diversifolium, which has Medical and Economic Value

   Tuba Türkoğlu, Semra Türkoğlu

   pp. 292–299 · DOI: 10.5530/ijpi.20270108 · 2026

   Background: Verbascum diversifolium, an endemic medicinal plant native to Türkiye, is recognized for its potential therapeutic and economic value. This study aimed to evaluate the antimicrobial, antioxidant, total phenol…

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9. Article

   Pareto Analysis-Based Risk Stratification and Prevention Strategies for Adverse Drug Reactions in our Hospital (2022-2025)

   Yuanchao Kang, Shizhe Chen, Yanwen Hao, Yan Lin

   pp. 300–309 · DOI: 10.5530/ijpi.20270131 · 2026

   Background: Adverse Drug Reactions (ADRs) severely affect clinical medication safety, and the Pareto principle is widely applied to identify key risk factors in pharmacovigilance. Systematic retrospective analysis of hos…

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10. Article

    Development and Evaluation of Voriconazole-Loaded Ethosomal Gel for Enhanced Topical Delivery in Cutaneous Candidiasis

    Mitali Milind Bodhankar, Shrushti Soitkar, Snehal Shrivastav, Shubham Gupta, Pranali Band

    pp. 310–321 · DOI: 10.5530/ijpi.20270132 · 2026

    Background/Objectives: Cutaneous candidiasis remains a significant clinical challenge, particularly in warm, moist body regions and immunocompromised individuals. This study focuses on the development and evaluation of a…

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11. Article

    Comparative in vitro Evaluation of the Antioxidant Potential of Apomorphine and Pyrazolones for Hepatocellular Carcinoma

    Hema Barti, Krishana Kumar Sharma

    pp. 322–328 · DOI: 10.5530/ijpi.20270134 · 2027

    Background: Hepatocellular Carcinoma (HCC) is a common and highly aggressive form of cancer worldwide. Oxidative stress is closely associated with the development and progression of HCC. An excessive increase in Reactive…

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12. Article

    Herbal Effervescent Tablet for Stress Management: Development and Characterization

    Priyanka Shah, Riya Patel, Shreeraj Shah

    pp. 329–337 · DOI: 10.5530/ijpi.20270173 · 2027

    Background: Stress management remains a significant therapeutic challenge, necessitating the development of novel delivery systems that enhance patient adherence. This research presents the formulation and characterizati…

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13. Article

    Formulation and Evaluation of Metronidazole Liposomal Gel for Topical and Mucosal Delivery

    Ladi Alik Kumar, Gurudutta Pattnaik, Himansu Bhusan Samal, K Naga Jogayya, Chandra Sekhar Patro, Gopal Krishna Padhy

    pp. 338–344 · DOI: 10.5530/ijpi.20270206 · 2026

    Background: Metronidazole is a commonly prescribed nitroimidazole antibiotic for Bacterial Vaginosis (BV), rosacea, periodontal infections, and other anaerobic or protozoal infections. However, conventional topical dosag…

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14. Article

    Exploration on Pharmacology Teaching Model and Practice Strategy Oriented Towards “Specialized Innovation Integration”

    Yan-Ling Wu, Cui Zhen-Yu

    pp. 345–349 · DOI: 10.5530/ijpi.20270219 · 2027

    Background: As an important discipline in medicine and pharmacy, pharmacology teaching needs constant improvement to adapt to social demands and technological developments. This study proposes suggestions based on “speci…

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15. Article

    Computational Identification of Small-Molecule Inhibitors Targeting TEAD2 Palmitoylation Pocket in Lung Cancer

    Amani Alharthi

    pp. 350–361 · DOI: 10.5530/ijpi.20270225 · 2026

    Background: Lung carcinoma is one of the most important health problems in the world and there is a need to develop effective and less toxic therapeutic agents. Computational drug discovery is an efficient approach for d…

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16. Article

    Dihydroartemisinin Alleviates Diclofenac Sodium-Induced Small Intestinal Mucosal Injury by Regulating the MAPK/NF-κB Signaling Pathway and Gut Microbiota Homeostasis

    Chun-Mei Wang, Bo Shen, Chen-Yan Xu, Jing Zhang, Lu Yang, Ren-Zheng Huang, Hua Chen

    pp. 362–372 · DOI: 10.5530/ijpi.20270229 · 2027

    Background: Dihydroartemisinin (DHA), a well-established antimalarial agent has been increasingly recognized for its antiviral and antitumor effects across multiple diseases. However, the potential effects of DHA on Non-…

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17. Article

    Comparative Evaluation of the Antimicrobial Effects of Xylitol, Aspartame, and Stevia and the Antibiofilm Activity of Stevia against Escherichia coli: An in vitro Study

    Varsha Mugundhan, Priyangha Ponmudi Thangavel

    pp. 373–380 · DOI: 10.5530/ijpi.20270230 · 2026

    Background: Artificial sweeteners are widely used as non-cariogenic alternatives to dietary sugars, and beyond their sweetening properties, certain sweeteners have demonstrated antimicrobial activity, suggesting potentia…

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18. Article

    Chemometric-Assisted ATR-FTIR Spectroscopy for Rapid Authentication and Quality Evaluation of Marketed Antidiabetic Tablet Formulations

    Pranay Kumar Ravula, Lakshmi Manogna Parupudi, Pravalika Pottigari, Jahnavi Bandla

    pp. 381–400 · DOI: 10.5530/ijpi.20270240 · 2026

    Background: The widespread availability of branded and generic antidiabetic tablet formulations has increased the need for rapid, reliable, and cost-effective analytical methods to ensure their authenticity and quality. …

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19. Article

    Formulation and Optimization of Self Emulsifying Drug Delivery System for Enhanced Solubility and Oral Bioavailability of Amisulpride Using Design of Expert Approach

    Vipul Kumar, Vaibhav Rastogi

    pp. 401–429 · DOI: 10.5530/ijpi.20270253 · 2027

    Background: Amisulpride, a Biopharmaceutics Classification System (BCS) Class II antipsychotic drug, exhibits limited aqueous solubility, resulting in poor dissolution and suboptimal oral bioavailability. Self-Emulsifyin…

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20. Article

    Layer-by-Layer Bioprinted Constructs Embedding Antimicrobial Agents with Regenerative Factors for Chronic Tissue Repair

    Pranaya Peram, Geetha Karra, Pravalika Patlolla, V Uma Maheswara Rao

    pp. 430–439 · DOI: 10.5530/ijpi.20270241 · 2026

    Background: Chronic wounds, including diabetic ulcers, pressure ulcers, and burn injuries, are characterized by persistent infection, prolonged inflammation, and impaired tissue regeneration, making them difficult to tre…

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