Volume 16, Issue 4

Deepak C G, Juno Jerold Joel, Shrinivasa Undaru Bhat

pp. 607–612 · DOI: 10.5530/jyp.2024.16.78 · 2024

Schizophrenia is a complex psychiatric disease with an unknown aetiology affecting the biological functions of the brain. It is a psychiatric condition affecting both genders irrespective of race, social class and reside…

Vijayakumar Subash, Parimalakrishnan S, Prem Anand DC, Kaviya E, Vijayakumar AR

pp. 613–619 · DOI: 10.5530/jyp.2024.16.79 · 2024

Osteoporosis diagnosis relies primarily on a clinical assessment involving the observation of signs and symptoms. The origins of this disorder may be either causative or risk-related, with some factors being preventable …

Phaik Har Yong, Wong Xue Yi, Meram Azzani, Rhanye Mac Guad, Zhi Xiang Ng

pp. 620–632 · DOI: 10.5530/jyp.2024.16.80 · 2024

Several studies have established that diabetes can exacerbate the neurodegeneration process. Some studies have reported the potential use of medicinal plants to inhibit neurodegenerative activities in diabetes. Therefore…

Phaik Har Yong, Shirley Ling Zin Yii, Meram Azzani, Deepa Anbazhagan, Zhi Xiang Ng

pp. 633–641 · DOI: DOI: 10.5530/jyp.2024.16.81 · 2024

Diabetic Retinopathy (DR) is one of the most common diabetic complications which can lead to vision loss if left unattended. Medicinal plants are considered as a treatment option for its lesser side effects. Given the ov…

Reshma Kottila, Johnson Vimalin Hena

pp. 642–652 · DOI: 10.5530/jyp.2024.16.82 · 2024

This review explores the diverse properties and applications of Annona muricata, referred to as soursop or graviola. The historical significance of medicinal herbs, particularly Annona muricata, was used in ancient medic…

Singareddy Yasaswini, Chinthaginjala Haranath, Lavani Firdos, Rompicharla Narasimha Sai, Turubilli Satish

pp. 653–659 · DOI: 10.5530/jyp.2024.16.83 · 2024

The field of ufasomes has great promise for revolutionizing drug delivery. Ufasomes have the potential to overcome limitations, enhance medicine and therapy and pave the way for future pharmacological formulations that a…

Jithin Mathew, Kolathur Ragesh, Divya Gupta Palottil Kunhunni, Sreelekha Sreekumar, Anchu Chandrababu

pp. 660–666 · DOI: 10.5530/jyp.2024.16.84 · 2024

Atherosclerosis is a primary factor in many cardiovascular diseases. Current treatments lack effectiveness in reducing the risk and progression of the disease, highlighting the need for better preventive measures. Precis…

Sajidul Hoque Ansari, Saikat Sen

pp. 667–672 · DOI: 10.5530/jyp.2024.16.85 · 2024

Diabetic neuropathy is a prevalent and painful condition impacting the nervous system and a common clinical consequence of Diabetes Mellitus (DM). Effective management of various forms of Diabetic Neuropathy (DN), such a…

Akhila Eldo Parambi, Selin Chiriyankandath Joy, Mazhuvancherry Kesavan Unnikrishnan, Prashant Chandra

pp. 673–680 · DOI: 10.5530/jyp.2024.16.86 · 2024

Thiazide Induced Hyponatremia (TIH) is one of the main causes of fatal hyponatremia among elderly. The global and Indian prevalence ranges from 4-14% and 30%, respectively. This paper reviewed the clinical implications o…

Jennifer Buela P, Jayashri Prabakar, Meignana Arumugham Indiran, Ganesh Jeevanandan, Rajesh Kumar Shanmugam

pp. 687–696 · DOI: 10.5530/jyp.2024.16.88 · 2024

The traditional preventive method for treating decay often entails resin-based sealants, topical fluoride application and Glass Ionomer based sealants (GIC sealants). At present, topical fluoride application is less effe…

Arunraj Tharamelveliyil Rajendran, Anoop Narayanan Vadakkepushpakath

pp. 697–705 · DOI: 10.5530/jyp.2024.16.89 · 2024

Glioblastoma Multiforme (GBM) is still one of the most aggressive and resistant brain tumours, and current treatment options provide only minimal improvements in survival. Effective drug delivery is severely hampered by …

Sunayana Vikhe, Apeksha S. Fulsundar, Rahul Vikhe

pp. 706–713 · DOI: 10.5530/jyp.2024.16.90 · 2024

Background:In the conventional Indian medical system, Cupressus sempervirensL., a member of the Cupressaceae family, is highly significant. C. sempervirensis a traditional medicinal plant; has been reported in the litera…

Krishnan Shalini, Rajavel Varatharajan, Hamid Shahrul, Palanimuthu Vasanth Raj, Venugopal Vijayan

pp. 714–724 · DOI: 10.5530/jyp.2024.16.91 · 2024

Background:Triple-Negative Breast Cancer (TNBC) presents a significant clinical challenge due to its aggressive nature and limited therapeutic options. A promising treatment strategy involves targeting Epidermal Growth F…

Kavitha K, Jothikanth V, Kaniga P, Manoj Kumar S, Revathi P, Esakiprasanth R, Mohan S, Gowri Shankar NL, Jubilee R, Srinithi M, Lokesh Kumar H

pp. 725–734 · DOI: 10.5530/jyp.2024.16.92 · 2024

Background:Quinazolinone compounds are a preferred class of multi-agent therapeutics in the domains of biology and pharmacology. One of this scaffold's most notable biological functions is its anticancer properties. Nume…

Ganesh Paleti, Ashutosh Jena, Gokula Krishnu, Bharath Kumar Chagaleti, Dudhe Prashik Bhimarao, Shanthakumar Balakrishnan

pp. 735–744 · DOI: 10.5530/jyp.2024.16.93 · 2024

Background:Tuberculosis (TB) is a leading airborne disease, impacting millions annually and ranking among the top ten causes of global mortality. Post-COVID-19, TB incidence has increased due to its pulmonary nature, whi…

Arram Madhavi, Medidi Srinivas, Niraj Gupta

pp. 745–752 · DOI: 10.5530/jyp.2024.16.94 · 2024

Background:Human Immunodeficiency Virus is a debilitating viral infection that compromises the immune system, rendering individuals vulnerable to opportunistic infections. While antiretroviral therapy can effectively man…

Venugopal Vijayan, Sengamalam Ravindran, Anbazhagan Sockalingam

pp. 753–761 · DOI: 10.5530/jyp.2024.16.95 · 2024

Background:Remdesivir is a antiviral drug, which has approved in COVID-19 pandemic as emergency use. In order to solubilize the remdesivir in injection form, Sulfobutylether-Beta- Cyclodextrin (SBECD) is used as solubili…

M Mahesh, Harish K H, Fatima Sanjeri Dasankoppa, Kamaladevi Kshatriya, Rohan Latwade, Pranav Patil, Aditya Shivanand Hiremath, Agadi Hiremath Viswanatha Swamy

pp. 762–771 · DOI: 10.5530/jyp.2024.16.96 · 2024

Background:Fast Disintegrating Tablets (FDTs) are crucial in pharmaceuticals for rapid drug onset and improved patient compliance, particularly for those who have difficulty swallowing. Chlorpheniramine Maleate (CPM), an…

Saritha Dunaka, Krishnaveni Janapareddi

pp. 772–780 · DOI: 10.5530/jyp.2024.16.97 · 2024

Background:Nebivolol hydrochloride is a beta blocker used to treat hypertension but has low oral bioavailability (12%) because of first-pass metabolism by CYP3A enzymes. Hence to improve bioavailability, nebivolol hydroc…

Aswathy Melel Somarajan, Balaiahgari Mani Raja Rao, Donthula Pushpa, Anke Sai Kumar, Goruntla Narayana, Venkata Ramana, Akkiraju Sudheer

pp. 781–786 · DOI: 10.5530/jyp.2024.16.98 · 2026

Background: Proton pump inhibitors are used for suppressing gastric acid secretion. They are among the most routinely prescribed drugs globally due to their excellent efficacy and low risk of side effects, yet they are f…