Formulation Design of Sel-Micro-Emulsifying Lipid Systems
Naser M.Y. Hasan1★★ Corresponding author
- 1Pharmaceutical Sciences Department-PharmD Program, Fakeeh College for Medical Sciences, Jeddah, SAUDI ARABIA.
CORRESPONDENCE
Naser M.Y. Hasan
Pharmaceutical Sciences Department-PharmD Program, Fakeeh College for Medical Sciences, Jeddah, SAUDI ARABIA.
Received: 14-03-2025; Revised: 09-05-2025; Accepted: 28-07-2025.
Volume 17, Issue 3 · pp. 620–626 · PUBLISHED · DOI: 10.5530/jyp.20250153
ABSTRACT
Background:The increasing interest in the field of Lipid Self-Emulsifying Technology (LSET) is due to the fact that 40% of new chemical entities exhibit poor oral bioavailability because of their low water solubility. Self-Micro-Emulsifying Drug Delivery Systems (SMEDDS) are isotropic mixtures of oils, surfactants, and cosurfactants, which under gentle agitation in aqueous media form oil-in-water nano-emulsions of oil droplet size <100 nm. Materials and Methods:Self-emulsification process carried out at varying key compositions in the lipid mixtures; oil, cosurfactant and surfactant. Oil droplet size was measured using laser diffraction and light scattering techniques. Equilibrium phase behavior studies were carried out and phase boundaries were determined mapped out. Results:At least 40% w/w of cremophor EL is needed to obtain all the way through clear self-emulsifying clear dispersions (L2→L1) on the progressive addition of water. Maximum aqueous solubilization as L2 phase occurred at ≈ 55% w/w for miglyol 812 and {tagat TO/imwitor 988} blends at ratios of either (7:3). Conclusion:Successful self-micro-emulsifying lipid formulations were developed using droplet size measurements and equilibrium phase studies. Key elements in the oil blends were optimized which includes, type of oil, co-surfactant, surfactant and oil:co-surfactant ratio. Phase dynamic behavior due to the interaction of lipid vehicle with the aqueous media was investigated in an attempt to understand mechanistic of emulsification.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Hasan, N. M. (). Formulation Design of Sel-Micro-Emulsifying Lipid Systems. Journal of Young Pharmacists, 17(3), 620–626. https://doi.org/10.5530/jyp.20250153