Volume 8, Issue 4

Ramalingam Peraman, Hari Hara Theja Dugga

pp. 293 · DOI: 10.5530/jyp.2016.4.1

As per the Pharmacy practice regulation of Pharmacy council of India, 2015 there are numerous numbers of pharmacist roles have been described in the official gazette of Govt. of India. The participation of a registered p…

Ritu Gupta, B. M. Gupta, Jivesh Bansal, Ashok Kumar

pp. 294–301 · DOI: 10.5530/jyp.2016.4.2

The present study examines 579 Indian publications on “Migraine” research as covered in Scopus database during 2006-15, experiencing an annual growth rate of 17.37%, citation impact per paper of 8.32, international colla…

Ritu Gupta, B. M. Gupta, Kiran Baidwani, Jeevanjyot Kaur

pp. 302–309 · DOI: 10.5530/jyp.2016.4.3

The present study examines 536 Indian publications on “Vitamin D Deficiency” as covered in Scopus database during 2006-15, experiencing an annual average growth rate of 37.08%, citation impact per paper of 8.30 and inter…

K K Mueen Ahmed, B. M. Gupta, Ritu Gupta

pp. 310–318 · DOI: 10.5530/jyp.2016.4.4

The paper examines 8519 publications on clinical pharmacology research in India as covered in Scopus database during 2005-14, using various quantitative and qualitative parameters with a focus on its growth, citation qua…

Prince Prashant Sharma, Anurag A, Ram Kumar Roy, Rajneesh Dutt Kaushik, Vipin Kumar Sharma

pp. 319–323 · DOI: 10.5530/jyp.2016.4.5

Objective:The present study projected to the synthesis of 3b-Hydroxy-lup- 20(29)-en-28-oic acid analogues in order to evaluate their possible biological activity. In addition, the structure–activity relationship is also …

Divyesh Harshadkumar Shastri, Hitesh Dhirubhai Dodiya, Pragna Shelat, Alkesh Kishanlal Bhanupriy

pp. 324–329 · DOI: 10.5530/jyp.2016.4.6

Objective: To develop a gastroretentive in situ oral gel to improve the bioavailability of the cephalosporin antibiotic drug, Cefuroxime Axetil. Methodology:Sodium alginate and pectin were the ionic dependent gel forming…

Sokkalingam Arumugam Dhanaraj, Selvadurai Muralidharan, Vijayan Venugopal, Puspavathy Kanniappan, Winnie Tan Sze Hui, Lim Li Qi

pp. 330–334 · DOI: 10.5530/jyp.2016.4.7

Objective: The aim of the present study is to prepare and evaluate nanoparticles containing methotrexate using chitosan as the polymer. The MTX-loaded CS-NPs were prepared by the emulsion polymerization method using glut…

Marwa Helmy Abdallah, Shereen Ahmed Sabry, Azza Ali Hasan

pp. 335–340 · DOI: 10.5530/jyp.2016.4.8

Objective: The aim of this study is to formulate and evaluate proniosomal gel formulations as transdermal delivery systems of glimepiride (GM) to improve its therapeutic efficacy. Methods:Proniosomal formulations have be…

Manimaran Vasanthan, Damodharan Narayanasamy

pp. 341–349 · DOI: 10.5530/jyp.2016.4.9

Objective:The aim of the present study is to design oral fast-release tablets of nisoldipine and to optimize the drug dissolution profile by modifying the carrier concentration. Poloxamer 407 and Poloxamer 188 were selec…

Sriram Pavani, Yamsani Madusudhan Rao, Yamsani Shravan Kumar

pp. 350–355 · DOI: 10.5530/jyp.2016.4.10

Objective:In this study, a Box-Behnken design (BBD) of response surface method was used to investigate and optimize the process parameters of Repaglinide. Repaglinide is a suitable candidate for iontophoretic delivery du…

Santosh Kale Nemichand, Sharada Deore Laxman

pp. 356–367 · DOI: 10.5530/jyp.2016.4.11

Nebivolol is a third-generation beta-a drenoceptor antagonist. It differs from other beta-a drenoceptor an tagonists as it combines highly selective beta (1)-adrenoceptor antagonist properties with nitric oxide-mediated …

Apurva Jatinbhai Maniyar, Grishma Mahendrabhai Patel, Pragna Krishnachandra Shelat, Anita Nanikram Lalwani

pp. 368–377 · DOI: 10.5530/jyp.2016.4.12

Purpose:The objective of the present investigation was to fabricate a thermosensitive gel containing paliperidone loaded microspheres for the treatment of schizophrenia for brain delivery through nasal route. Incorporati…

Roopesh Poojary, Nayanatara Arun Kumar, Reshma Kumarachandra, Ganesh Sanjeev

pp. 378–384 · DOI: 10.5530/jyp.2016.4.13

Background:Antioxidant plays a key role in preventing and scavenging free radicals providing safeguard to humans against diseases. Recent research has been directed towards “Natural antioxidants” from the herbal plants d…

Ujwala TK, Sandra Celine, Shawn Tomy, Arulraj P, Sam Johnson Udaya Chander J

pp. 385–390 · DOI: 10.5530/jyp.2016.4.14

Background: Diakure is an indigenously prepared hypoglycemic polyherbal formulation, containing mixture of Vetiveria zizanoides(root), Hemidesmus indicus (rhizome), Strychnos potatorum (seed), Salacia reticulata (bark), …

Mohammad Shah Hafez Kabir, Mohammed Munawar Hossain, Md. Imtiazul Kabir, Md. Mominur Rahman, Abul Hasanat, Talha Bin Emran, Md. Atiar Rahman

pp. 391–397 · DOI: 10.5530/jyp.2016.4.15

Objective: Present study aims to investigate both qualitative and quantitative phytochemicals presence, antioxidant, thrombolytic, α-amylase and cytotoxic activity of a Bangladeshi plant Steudnera colocasiifolia K. Koch …

Sathianarayanan S, Asha Jose, Ranganathan Balasubramanian, Diana Thomas, Ashitha Balakrishnan, Rajasekaran Aiyalu

pp. 398–405 · DOI: 10.5530/jyp.2016.4.16

Objective: The current study investigates the potential of alcoholic extract of Wrightia tinctorialeaves and its isolates in repairing the DNA damage induced by gamma radiation. Methodology: The ethanolic extract ofWrigh…

Mondal Prasenjit, Shobharani Satla, Ramakrishna Raparla

pp. 406–414 · DOI: 10.5530/jyp.2016.4.17

Background:A novel LC-MS/MS method was developed for the estimation of blonanserin (BLN) in spiked human plasma. Methods: Liquid-liquid extraction (LLE) technique was adopted for the extraction of BLN from human plasma a…

Md Aftab Alam, Niyaz Ahmad, Rizwan Ahmad, Sushama Talegaonkar, Farhan Jalees Ahmad, Zeenat Iqbal, Amulya K. Panda

pp. 415–423 · DOI: 10.5530/jyp.2016.4.18

Objective:The present work aims to develop and validate stability indicating a novel liquid chromatography method with applicability i.e. to study the pharmacokinetics factor as well as estimate Tamoxifen (TMX) in bio-an…

Keerthisikha Palur, Bharathi Koganti, Sreenivasa Charan Archakam, Sridhar Chenchugari, Bhavana Nagireddy, Mahesh Babu Devabhaktuni, Meenakshi Sankranthi

pp. 424–429 · DOI: 10.5530/jyp.2016.4.19

Objective: To develop the UV-spectrophotometric method and to apply the Chemometric designs to the developed method for the simultaneous estimation of Atorvastatin calcium (ATR) and Aspirin (ASP) in intact capsule dosage…

Girish Pai Kulyadi, Muddukrishna Badamane Sathyanarayana

pp. 430–435 · DOI: 10.5530/jyp.2016.4.20

A sensitive, accurate, precise and stability indicating high-performance thin layer chromatographic method was developed and validated for analysis of triamcinalone acetonide (TRIA) in bulk drug and sterile injectable su…