Solubility Enhancement of Nebivolol by Micro Emulsion Technique
Santosh Kale Nemichand1★, Sharada Deore Laxman2★ Corresponding author
- 1Department of Pharmaceutical Sciences, ShriJagdish Prasad JhabarmalTibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, INDIA.
- 2Department Pharmacognosy, Govt. College of Pharmacy, Amravati, INDIA.
CORRESPONDENCE
Santosh Kale Nemichand
Department of Pharmaceutical Sciences, ShriJagdish Prasad JhabarmalTibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, INDIA.
Volume 8, Issue 4 · pp. 356–367 · PUBLISHED · DOI: 10.5530/jyp.2016.4.11
ABSTRACT
Nebivolol is a third-generation beta-a drenoceptor antagonist. It differs from other beta-a drenoceptor an tagonists as it combines highly selective beta (1)-adrenoceptor antagonist properties with nitric oxide-mediated vasodilator actions and beneficial effects on endothelial function. But this very useful drug use is limited due to challenge of poor water solubility (0.0403 mg/ml). Present study deals with enhancement of solubility of Nebivolol by micro emulsion technique. Various oils, surfactants, and co-surfactants were used to check solubility of Nebivolol. Pseudoternary phase diagrams were constructed using various combinations of ingredients i.e. oil: surfactant: co-surfactant. Micro emulsion batches were prepared by phase titration method. Developed micro emulsion was evaluated for various physicochemical, stability parameters, in-vitro and ex-vivo parameters. Results showed stable micro emulsion form of Nebivololimproved solubility.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Nemichand, S. K., & Laxman, S. D. (). Solubility Enhancement of Nebivolol by Micro Emulsion Technique. Journal of Young Pharmacists, 8(4), 356–367. https://doi.org/10.5530/jyp.2016.4.11