Pharmacognosy Research
Volume 17, Issue 4
Oct-Dec 2025 · pp. 1077–1398 · 36 articles
- Volume
- 17
- Issue
- 4
- Published
- Oct-Dec 2025
- Pages
- 1077–1398
- Articles
- 36
- Sections
- 3
- ISSN
- Print - 0976-4836, Online - 0974-8490
- Journal
- PR
In this issue
Review Article
- Review
Therapeutic Potentials of Piper betle Leaf: Insights into Its Medicinal Uses and Bioactive Compounds
Ruchi Tiwari, Shivam Verma, Pranshul Sethi, Pijush Dutta, Rajesh Devarai
pp. 1077–1097 · DOI: 10.5530/pres.20252107 · Published Oct-Dec 2025
Plant extracts, composed of bioactive non-nutrient phytochemicals, have historically stood out as a primary reservoir for the development of new leads in anticancer drug research. Piper betel (L.), a widely cultivated pl…
- Review
Amaranthus dubius L.: Ethnomedicinal Significance, Phytochemical Profile, and Therapeutic Potential: A Review
Bagepalli Srinivas Ashok Kumar, Nanjundiya Sadashiva Disha, Mohammed Khalid
pp. 1098–1103 · DOI: 10.5530/pres.20252187 · Published Oct-Dec 2025
Amaranthus dubius, also known as red spinach, is widely recognized for its therapeutic potential in traditional medicine, particularly across tropical and subtropical regions. This review compiles and analyses ethnomedic…
- Review
Terpenoids as Natural Anti-Inflammatory Agents: A Review of their Biological Mechanisms
Sarika Sapan Parekh, Rahul Trivedi, Divya Kanojiya, Sunil Bhaurao Baile, Riddhi Nimeshkumar Parikh, Sakshiben Mehta, Ghanshyam Ratilal Parmar
pp. 1104–1115 · DOI: 10.5530/pres.20252308 · Published Oct-Dec 2025
Body’s Immune system biological response also known as inflammation and it is stimulated by varied factors such as pathogenic organisms, ruptured cells and toxic components. The given factors can initiate inflammatory re…
- Review
Adulteration in Herbal Medicines: A Comprehensive Review on Types, Detection, and Health Impacts
Ravjot Kaur, Tirath Choudhary, Ramandeep Kaur, Mansi Garg, Nagendra Singh Chauhan, Abhilasha Jain, Ashish Baldi
pp. 1116–1126 · DOI: 10.5530/pres.20250085 · Published Oct-Dec 2025
Background: Adulteration of herbal medicines is a large-scale issue that compromises the quality, safety, and therapeutic effect of herbal drugs. It entails deliberate substitution, contamination, and incorporation of un…
- Review
Herbal Remedies for Pain: A Focus on Plant-Based Solutions
Niyati Shah, Ritu Sapra, Mamta Kumari, Piyushkumar Sadhu, Chitrali Talele
pp. 1127–1131 · DOI: 10.5530/pres.20252325 · Published Oct-Dec 2025
Herbal remedies have been used for centuries to manage pain, offering a natural alternative to conventional pharmaceuticals. With growing concerns about the side effects of synthetic medications, plant-based solutions ar…
- Review
A Comprehensive Analysis of Ayurvedic Treatments for Asrigdara (Heavy Menstrual Bleeding)
Trapti Agrawal, Hemanta Panigrahi
pp. 1132–1139 · DOI: 10.5530/pres.20250026 · Published Oct-Dec 2025
Objectives:To assess the effectiveness and safety of Ayurveda treatment for managing Asrigdara (Heavy menstrual bleeding). Materials and Methods: Electronic databases for published research articles, and doctoral thesis …
- Review
Secondary Metabolite as Therapeutic agents with Significant Highlight on Terpenoids
Sarika Sapan Parekh, Rahul Trivedi, Divya Kanojia, Sweta Ba Besh, Maitri Mahant, Ghanshyam Ratilal Parmar
pp. 1140–1147 · DOI: 10.5530/pres.20252366 · Published Oct-Dec 2025
The belief that plants possess biologically active compounds with healing properties beneficial for treating various health conditions has endured since ancient times. The therapeutic importance of these plants highlight…
- Review
Pharmacological Review of Anti-Obesity Herbs from Chakradatta: Insights and Mechanisms
Arushi Saroch, Giramalla Patil, Swapnil Yashwant Chaudhari, Pramod Yadav, Galib Ruknuddin, Pradeep Kumar Prajapati
pp. 1148–1162 · DOI: 10.5530/pres.20250135 · Published Oct-Dec 2025
Background:Obesity has become a major global health crisis, significantly increasing the risk of Type 2 diabetes, cardiovascular diseases, and certain cancers, while placing a considerable economic burden on healthcare s…
- Review
A Comprehensive Review of Crocus sativus L.: Botanical Characteristics, Phytochemical Composition, and Therapeutic Applications
Mahavir M. Sharma, HarshKumar Brahmbhatt, Salaj Khare, Kautuukumar P Shah
pp. 1163–1170 · DOI: 10.5530/pres.20252301 · Published Oct-Dec 2025
Known as saffron (syn. Kesar), Crocus sativus L., a member of the Iridaceae family, is mostly grown in Iran, though it is also grown in India and Greece. It is made from the dried red stigmas of the flower. Terpenes, ter…
- Review
Phytochemical and Pharmacological Properties of Tinospora cordifolia (Giloy)
Richa Kothari, Manoj Kumar Bajhaiya, Shefali Soni, Abhishek Kumar, Samreen Ali, Ankit Rajput, Prashant kumar, Sagar Shrotriya, Kanchan Thakur
pp. 1171–1182 · DOI: 10.5530/pres.20252350 · Published Oct-Dec 2025
Tinospora cordifolia (commonly known as Giloy or Guduchi) is a revered herb in traditional Ayurvedic medicine, widely recognized for its rejuvenating properties. The plant’s therapeutic effects stem from a rich profile o…
- Review
Hedychium spicatum (Shati): A Comprehensive Review of its Pharmacological Activities and Phytochemical Constituents
Krupa Joshi, Ashimkumar Sen, Dhanya B. Sen, Aarti S. Zanwar, Vatsal Gujariya
pp. 1183–1186 · DOI: 10.5530/pres.20252217 · Published Oct-Dec 2025
Ayurvedic medicine, originating from historical Indian customs, is a comprehensive and revered treatment approach that recognizes the inter-connectedness of the body, mind, and spirit. Hedychium spicatum Buch-Ham (Zingib…
Original Article
- Article
Comparative LC-MS Profiling of two Linderniaceae Species
Thachan Sreelakshmi, Meethaley Valappil Jeeshna, Abhijith Sarga, Sugunan Ashitha
pp. 1187–1196 · DOI: 10.5530/pres.20252214 · Published Oct-Dec 2025
Introduction: The presence of the phytochemical constituents has been reported from species of the Linderniaceae family. Objectives: The present study was designed to determine the bioactive compounds in the whole plant …
- Article
Investigating the Expression of Apoptosis and Metastasis Genes in Satureja khuzistanica along with Nisin and Doxorubicin in Colorectal Cancer
Esmaeil Kheiri, Zahra Hojjati Bonab, Hossein Soltanzadeh
pp. 1197–1204 · DOI: 10.5530/pres.20252194 · Published Oct-Dec 2025
Background: Colorectal cancer is the third most common cancer and the second most common cause of cancer-related death worldwide. Common treatments for colorectal cancer include chemotherapy, surgery, immunotherapy, etc.…
- Article
Nephroprotective and Cytotoxic Assessment of Moringa concanensis Leaf Extract in Gentamicin-Induced Renal Injury in Rats
Abhishek Raghavendra, Hariprasad Madakasira Guggilla, Diya Lakshman Shetty, Deeksha Giridhar
pp. 1205–1213 · DOI: 10.5530/pres.20252208 · Published Oct-Dec 2025
Background: Gentamicin-induced nephrotoxicity is a significant clinical concern, characterized by tubular necrosis and impaired renal function. This study aimed to evaluate the in vitro antioxidant and cytotoxic properti…
- Article
Evaluation of Anti-Depressant Activity of Garcinia cambogia Fruit Using Animal Models
J. Priyadharisini, N. Savitha, Lydia Jeeboi Paramel
pp. 1214–1217 · DOI: 10.5530/pres.20252201 · Published Oct-Dec 2025
Background:Garcinia cambogia fruit popularly specified as (Guttiferae) Clusiaceae has been used for variety of diseases. Depression is mental disorder which affects person day to day activities. Objectives: The main aim …
- Article
Evaluation of Neuroprotective Potential of Water-Dispersible Turmeric Extract and Sustained-Release Ashwagandha Root Extract against B[A]P Induced Neurotoxicity in Zebrafish
Tushar Lokhande, Madhusudan Saraf, Jaya Agnihotri, Nikhat Khan, Tejal Dhotre, Sneha Sawant Desai, Ritik Singh
pp. 1218–1225 · DOI: 10.5530/pres.20252280 · Published Oct-Dec 2025
Background:Numerous advantages of using herbs in the management of neurodegenerative disorders have been documented. Water-Dispersible Turmeric Extract Containing 60% Natural Curcuminoids (WDTE60N) and Sustained-Release …
- Article
Comparative HPTLC Fingerprinting Analysis of Yashtimadhu Medhya Rasayana in Different Media
Geeta Govindappa Gadad, Sanskar Ankush Maral, Bhumika Sundar, Pragati Vinaykumar Kotur
pp. 1226–1234 · DOI: 10.5530/pres.20252333 · Published Oct-Dec 2025
Background: Yashtimadhu (Glycyrrhiza glabra Linn.), classified as a Medhya Rasayana in Ayurveda, is traditionally administered with milk (Ksheera anupana) to enhance cognitive function. Despite these claims, the phytoche…
- Article
Green Synthesis and Characterization of Copper Oxide Nanoparticles Using Vitex negundo Linn.: An in vitro study
Pravallika Kakada, R Abilasha, Pratibha Ramani
pp. 1235–1240 · DOI: 10.5530/pres.20252186 · Published Oct-Dec 2025
Background:Nanotechnology offers innovative approaches for biomedical applications, including antimicrobial agent development. Copper Oxide Nanoparticles (CuO NPs) exhibit strong antibacterial properties, but conventiona…
- Article
Identification of Bioactive Metabolites in Bhadrikadi Ghrita: A Phytochemical and GC-MS Approach to Investigating Analgesic and Anti-inflammatory Properties
Raj Joshi, Santosh Mudakappagol, Adithya Anil
pp. 1241–1252 · DOI: 10.5530/pres.20252163 · Published Oct-Dec 2025
Background: Ayurveda healthcare system holds considerable reputation in today’s era. Treatises of Ayurveda explained numerous formulations with their potential therapeutic benefits but their global acceptance is poor due…
- Article
Accelerated Stability Study of Powder Formulation Safoof Muqliyasa and Safoof Mulayyin
Md Naquibuddin, Hamiduddin, Gazi Jahangeer Rather, Fakeha Firdous Khanbhadur, Mohammed Saad
pp. 1253–1273 · DOI: 10.5530/pres.20252160 · Published Oct-Dec 2025
Background and Objectives: Evaluation of stability studies of Unani Medicine (UM) formulations determined on the basis of scientific data are the need of the time and also recommended in D and C Act. There is immense nee…
- Article
Network Pharmacology Approach to Determine the Molecular Mechanism of Chitraka (Plumbago zeylanica L.) in the Treatment of Obesity
Prabhakar Basappa Hegade, Praveen Nagappa Bhirdi, Ajit Lingayat
pp. 1274–1280 · DOI: 10.5530/pres.20252331 · Published Oct-Dec 2025
Background:The state of excessive bodily fat buildup is known as obesity (Sthoulya). Anti-obesity drugs in the market might cause adverse effects, for safer and more effective anti-obesity medications from plant-based so…
- Article
Targeting Breast Cancer with Triazine Derivatives: A Molecular Docking Analysis of Her2 and Parp1 Inhibition
Thamizh Sendhamaraikannan, Nithish kumar Arivukkarasu, Ezhil Sakthivel, Abinaya Seevagavazhuthi, Venkatesan Natarajan, Pradeepraj Devarasu, Aravinth Velmurugan
pp. 1281–1292 · DOI: 10.5530/pres.20252332 · Published Oct-Dec 2025
Background:Heterocyclic compounds, particularly triazines, have significant attention in pharmaceutical and industrial research due to their broad spectrum of biological activities. Objective: This study focuses on the s…
- Article
Perioperative Administration of Oral Melatonin for Hemodynamic and Analgesic Control during Dental Implant Placement: A Clinical Study
Pavithran Janagarathinam, Arvina Rajasekar
pp. 1293–1297 · DOI: 10.5530/pres.20252345 · Published Oct-Dec 2025
Background: Despite melatonin’s established pharmacologic profile as an anxiolytic and antioxidant agent, its perioperative use in implant dentistry remains underexplored. As patient anxiety and hemodynamic fluctuations …
- Article
Modulation of Glucose Homeostasis and Behavioral Parameters by Passiflora edulis in a Rodent Model of Metabolic Syndrome Induced by High Fructose Intake
Kinjal P. Patel, Rajesh A. Maheshwari, Nilay Solanki, Jagdish Kakadiya
pp. 1298–1302 · DOI: 10.5530/pres.20252369 · Published Oct-Dec 2025
Background:Syndrome X (Metabolic syndrome), commonly associated with high-fructose dietary intake, is characterized by insulin resistance, hyperglycemia, and related neurobehavioral impairments. Passiflora edulis Extract…
- Article
Histochemistry and Powder Microscopy of Ceropegia juncea Roxb. - A Potent Medicinal Plant
Bhuvaneswari Manoharan, Chitra Vadivu Chinnasamy, Balakrishnan Veluchamy, Raja Kannan
pp. 1303–1307 · DOI: 10.5530/pres.20252315 · Published Oct-Dec 2025
Background:TheCeropegia junceaRoxb. Belongs to the subfamily Asclepiadoideae and the family Apocynaceae. The histochemistry is used to localize primary and secondary metabolites within the cells, which can be determined …
- Article
Comparative HPTLC Analysis of Piperine Content in Roots of Piper longum L. Cultivated with Bio Formulations
Adavesh Holeyache, Vishal Chaudhary
pp. 1308–1314 · DOI: 10.5530/pres.20252328 · Published Oct-Dec 2025
Background: Phytochemicals from medicinal plants significantly impact healthcare. Piperine, a bioactive compound in Piper longum, exhibits diverse pharmacological effects, including analgesic, antipyretic, antioxidant, i…
- Article
Exploring the Pharmacological Potential of Achyranthes aspera (Latzeera): A Complete Investigation of its Anticancer, Anti-Microbial and Antioxidant Activities
Arijit Chaudhuri, Biswajit Dash, Ashish Sarkar, Afrin Alam, Ayush Garg, Shivani Devi, Ankita Sharma, Varsha Chauhan, Tanbeer Kaur, Yashna Bawa
pp. 1315–1327 · DOI: 10.5530/pres.20252314 · Published Oct-Dec 2025
Background: A medicinal herb called Achyranthes aspera has been used for centuries to treat a wide range of illnesses. By assessing its antineoplastic, anti-microbial and antioxidant properties. This study sought to thor…
- Article
Flavonoid Rich Fraction of Methanol Extract of Capparis decidua Attenuates MDA-MB-231 Breast Cancer Cells
Nishi Shukla, Shazia Usmani, Sahabjada Siddiqui, Shadma Wahab, Rumana Ahmad, Shabana Khatoon, Sana Parveen, Arti Prajapati
pp. 1328–1334 · DOI: 10.5530/pres.20250003 · Published Oct-Dec 2025
Background:The research investigated the mechanism behind the antiproliferative activity of Capparis decidua (Family: Capparaceae). Despite being tested for other cell lines, its mechanism of action is still not well est…
- Article
Production and Properties of Bacterial Cellulase from Arecanut Waste
Vidya Avadhanam Sudhakar, Chandrakanth Shivappa Karigar, Nandhini Keshava Reddy, Chandana Narayana Swamy, Pattada Vitha Ramesh, Bhavya Janardhan, Sunil Shivaji More
pp. 1335–1340 · DOI: 10.5530/pres.20250019 · Published Oct-Dec 2025
Background: Cellulases are the second most popular industrial enzyme because of their many uses, especially in turning cellulosic biomass into sugars for further processing. Objectives: The current study focused on the i…
- Article
Isolation of Bioactive Metabolites from Tephrosia maxima and Tephrosia callophylla: A Phytochemical and Functional Study
Anoop Kumar, Abilasha Ramasubramanian, Priyadharshini Muthumanickam, Bargavi Purushothaman
pp. 1341–1347 · DOI: 10.5530/pres.20250024 · Published Oct-Dec 2025
Tephrosia maxima and Tephrosia callophylla, two lesser-studied members of the Fabaceae family, were evaluated for their phytochemical, pharmacological, and toxicological profiles in this study. Aqueous extracts from shad…
- Article
Medical Plants Aframomum melegueta and Xylopia aethiopica Show Low Toxicity in vitro and in vivo Highlighting their Potential for Therapeutic Applications
Essimanam Rosalie Awesso, Kathrin Arndts, Gnatoulma Katawa, Fekandine Victoire Douti, Fagdéba David Bara, Simplice Damintoti Karou, Achim Hoerauf, Manuel Ritter
pp. 1348–1361 · DOI: 10.5530/pres.20250030 · Published Oct-Dec 2025
Background: We previously demonstrated that crude Hydro-Ethanolic Extracts (HEE) of Aframomum melegueta (AM) and Xylopia aethiopica (XA) exhibited anti-helminthic and anti-inflammatory properties with low toxicity. Objec…
- Article
The Antioxidant Potential of Leaf, Bark, and Flower Extracts of Vateria indica L.
Manju Madhavan, Gayathri Haridas, Anu C Benny, Dalie Dominic A
pp. 1362–1366 · DOI: 10.5530/pres.20250027 · Published Oct-Dec 2025
Background:Vateria indica L. is an extremely endangered tree belonging to Family Dipterocarpaceae. In almost all Unani, Ayurveda, and Siddha medicines, the resin obtained from this tree is used to treat various diseases.…
- Article
Pharmcognostical and Phytochemical Investigations on Stachytarpheta indica
Karuna Modi, Rachna Varsani, Mihir Bhatt, Krupa Gadhvi, Mamta Shah
pp. 1367–1373 · DOI: 10.5530/pres.20252305 · Published Oct-Dec 2025
Background: Stachytarpheta indica (Family: Verbenaceae), is a tropical plant useful to treat respiratory disorders, dropsy, rheumatic inflammation, intestinal worms and diarrhea. Pharmacological studies indicate antimicr…
- Article
Phytochemical Analysis and Tissue Restoration Activity of Nelumbo nucifera Extract
Archana Shantaram Gadakh, Abhijeet Dattatray Kulkarni
pp. 1374–1381 · DOI: 10.5530/pres.20252311 · Published Oct-Dec 2025
Background:Flavonoids, alkaloids, tannins, saponins, and phenolic substances are among the several secondary metabolites that have been identified by phytochemical analysis of Nelumbo nucifera. The hepatoprotective, anti…
- Article
Box–Behnken Design Based Optimisation of HPTLC Method for Analysis of Jatrorrhizine from Tinospora cordifolia Roots with Antidiabetic Activity Assessment
Neeraj Kumar, Akanksha A, Rama Tyagi, Shubham Singh, Mohd Aqil, Abul kalam Najmi, Mohd Vaseem Ismail, Mohd. Mujeeb
pp. 1382–1394 · DOI: 10.5530/pres.20252320 · Published Oct-Dec 2025
Introduction: Tinospora cordifolia root (T. cordifolia) is a well-known Ayurvedic herb with immune-boosting, anti-inflammatory, and antioxidant properties. It contains Jatrorrhizine (JZ), a bioactive alkaloid with antimi…
Short Communication
- Communication
A Decade of Research on Plant-Based Anticancer Compounds: A Scientometric Analysis
Mueen Ahmed KK Ahmed, Chaman Sab
pp. 1395–1397 · DOI: 10.5530/pres.20250002 · Published Oct-Dec 2025
Cancer continues to be one of the leading global health challenges, driving increasing scientific interest in natural and plant-derived therapeutic alternatives. This study presents a scientometric analysis of global res…