Volume 21, Issue 3

Original Research Article(continued)

1. Article

   Proliferative Effects of Curcuma zedoaria Extract on Ovarian Tumor Cells

   Na Song, Xiuyun Wang, Mingxing Yuan

   pp. 959–973 · DOI: 10.1177/09731296241298344 · 2025

   Background: Curcuma zedoaria is a common traditional herbal medicine that contains mainly curcumin and volatile oils with antioxidant, anti-inflammatory, and antitumor properties. Objectives: This study aimed to investig…

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2. Article

   Polystyrene Nanoparticles-coated Astragalus Polysaccharides Affects the Development of Prostate Cancer by Regulating Glycolysis of DAP12/SYK Axis through miR-370

   Cheng Gao Gao, Zixiong Liu, Jiafu Tan

   pp. 974–983 · DOI: 10.1177/09731296241298361 · 2025

   Background: This study aims to explore the use of polystyrene nanoparticles as a carrier to encapsulate astragalus polysaccharides and regulate the glycolytic pathway of the DNAX-activating protein of 12 kDa/spleen tyros…

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3. Article

   Antiproliferative and Apoptotic Potential of Chicoric Acid, a Major Phytoconstituent of Cichorium intybus, against Colon Cancer Cells: A Possible Inhibition of CDC25 Phosphatases

   Modhi O. Alotaibi, Mahima Verma, Shireen Fatima, Nahaa M. Alotaibi, Nawaf Alshammari, Mohd Saeed, F. K. Alharbi, Irfan Ahmad Ansari

   pp. 984–1000 · DOI: 10.1177/09731296241291625 · 2025

   Background: Over the years, plants have been utilized worldwide for the treatment of cancer in the traditional system of medicine, notably in the majority of developing nations. The use of chemotherapeutic drugs is frequ…

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4. Article

   Bioflavonoid Tangeretin regulates RANK/RANKL/OPG Signaling Proteins via Stimulating Estrogenic Activity in Ovariectomized Rats

   Weike Tian, Wei Zhang, Li Chen, Junlei Liao, Xuesong Yang

   pp. 1001–1012 · DOI: 10.1177/09731296241296201 · 2025

   Background: Globally, osteoporosis has arisen as a significant health hazard, impacting over 200 million individuals. It is often reported in women, especially those who are in the postmenopausal stage. Even though numer…

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5. Article

   PhcogMag 21 3 1013

   Yanhong Zhang, Yanlong He

   pp. 1013–1021 · DOI: 10.1177/09731296241307737 · 2025

   Background: One significant consequence of sepsis and a major factor in death in critical care units is acute lung injury (ALI). Purpurin has been proven in studies to minimize oxidative stress and inflammation. Objectiv…

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6. Article

   Rosmanol Effectively Prevents Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats by Regulating the PI3K/Akt Signaling Pathway

   Wei Cao, Qi Liu, Ying Wang, Lianfeng Chen

   pp. 1022–1033 · DOI: 10.1177/09731296241298349 · 2025

   Background: Hepatocellular carcinoma (HCC) is the third principal reason for tumor-linked fatalities globally. There is no effective cure for HCC due to rapid progression and poor prognosis. Rosmanol (RM) is a phenolic d…

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7. Article

   Liquiritin Promotes Vasodilation Effects by Activating the Kv and KATP Channels in the Isolated Rat Thoracic Aorta

   MengXue Ma, YouLan Che, Xin Yang, Zhi Wang, Ya Wen Bai, Yang Yu, QingBin Xu, Ru Zhou

   pp. 1034–1042 · DOI: 10.1177/09731296241298360 · 2025

   Background: Liquiritin, a flavonoid present in the traditional Chinese medicine Radix Glycyrrhizae, reduces myocardial damage and improves cardiac function. However, it remains unclear what effect it has on the thoracic …

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8. Article

   Tomatidine, A Promising Steroidal Alkaloid Alleviates Various Noxious Stimuli Induced Nociception in Mice Model

   Jiajia Chen, Xi Wang, Dan Wang, Hengming Yin, Guoping Ma

   pp. 1077–1089 · DOI: 10.1177/09731296241307746 · 2025

   Background: Nociception, often described as the body’s ability to sense and respond to harmful stimuli, represents a global discomfort that profoundly impacts individuals across the globe. It functions as a fundamental w…

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9. Article

   Efficacy and Safety of Traditional Chinese Medicine Interventions in Unresponsive Mild-to-Moderate Ulcerative Colitis: A Meta-Analysis of Randomized Controlled Trials

   Aiyangzi Lu, Yan Sun, Hui Gao, Ping Chen

   pp. 1090–1099 · DOI: 10.1177/09731296241307093 · 2025

   Background: Treatments for ulcerative colitis (UC), a chronic inflammatory bowel illness, have been investigated using Traditional Chinese Medicine (TCM). Uncertainty surrounds the relative safety and effectiveness of TC…

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10. Article

    Cardioprotective Potential of Bioactive Compound from Methanolic Extract of Asparagus racemosus: An in silico Study Utilizing GC–MS Analysis

    Sandip Sen, Biswabara Roy, N. Kannappan, Khalid Zoghebi, Mohammed Albratty, Hassan A. Alhazmi, Asim Najmi, Md Shamsher Alam

    pp. 1100–1113 · DOI: 10.1177/09731296241300873 · 2025

    Background: Historical accounts suggest that, throughout antiquity, medicinal plants and their constituent parts have been used to treat a variety of ailments. Asparagus racemosus, this plant exhibits a wide range of pot…

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11. Article

    Effects of Motherwort on Biological Behavior of Brain Tissue in Rats with Ischemic Stroke and its Relationship with Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway

    Guangyu Cao, Jianju Zhou, Guoqing Yu, Xiaohong Fu, Bo Xiong

    pp. 1114–1123 · DOI: 10.1177/09731296241296204 · 2025

    Background: Motherwort has a protective effect on the nervous system and can improve cerebral ischemia–reperfusion injury to a certain extent. However, the effect of motherwort on the biological behavior of the brain tis…

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12. Article

    Wogonin Alleviates Aconitine-induced Gastric Tissue Damage in Gastric Cancer through PI3K/Akt Signaling Pathway

    Yiyue Fu, Xiaodong Tang, Yichen Hu, Shufeng Zheng

    pp. 1124–1131 · DOI: 10.1177/09731296241296601 · 2025

    Background and Objectives: Aconitine is a toxic substance capable of causing damage to the nervous system, digestive system, and gastric tissue. Wogonin exhibits significant antibacterial, antioxidant, and potential anti…

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