Volume 23, Issue 4

7 November 2025 · pp. 1–26 · 35 articles

Volume: 23
Issue: 4
Published: 7 November 2025
Pages: 1–26
Articles: 35
Sections: 2
ISSN: e-ISSN: 1886-3655 - p-ISSN: 1885-642X
Journal: PP

Original Research Review Article

In this issue

Original Research

Article
Quercetin encapsulated polymeric nanomicelles substantially chemosensitising antiproliferation by branched chain amino acids with enhanced antiinflammation capacities: A new strategy against adherent cancer monolayers
Violet Kasabri, Suhair Sunoqrot, Rasha Al-Motassem, Yusuf Al-Hiari, Riad Ababneh, Balqis Ikhmais, Hamza AbuMansour, Dalya Al-Saad, Dana Shalabi, Rema Alkhateeb
pp. 1–10 · DOI: 10.18549/PharmPract.2025.4.3061 · Published 7 November 2025
Background: Quercetin as a bioflavonoid with high anticancer potential, it has been proved to have a prospective applicability in chemotherapy for a series of cancers. PANC1, MCF7, CACO2, A375, A549 and PC3 cancer cell l…
Article
Conservation of Medicinal plants by sustainable aquaponics approach for novel drug development
Ramya Manoharan, Chythra Somanathan Nair, Drishya Nishanth, Radhakrishnan Subramanian, Xiulan Xie, Maozhi Ren, Abdul Jaleel
pp. 1–16 · DOI: 10.18549/PharmPract.2025.4.3234 · Published 13 November 2025
Medicinal plants are one of the significant elements of global population that play a pivotal role in healthcare and other sectors. The cultivation and trade of medicinal plants hold considerable economic value for a cou…
Article
Fostering empathy and social responsibility in pharmacy students through experiential service-learning: A qualitative study
Sabeena Salam, Semira Beshir, Sadaf Sana, Faizah Hussain, Aliasgar Shahiwala
pp. 1–8 · DOI: 10.18549/PharmPract.2025.4.3275 · Published 18 November 2025
Background: Pharmacy education is increasingly incorporating experiential learning approaches to develop holistic healthcare professionals. Key competencies like empathy, social responsibility, and interpersonal skills a…
Article
An investigative assessment on the quality of community pharmacy practice in the United Arab Emirates using common cold scenario
Subish Palaian, Muaed Alomar, Nageeb Hassan, Mukhtar Ansari
pp. 1–8 · DOI: 10.18549/PharmPract.2025.4.3287 · Published 28 November 2025
Background: Before dispensing medications to a patient, the pharmacist must obtain appropriate medical and medication history, label medications, and counsel. Due to its investigative and undercover nature, the simulated…
Article
Knowledge and practice of community pharmacists in identifying and managing dry eye disease in Klang Valley of Malaysia. A cross-sectional study
Tzu Hang Sia, Mei Qian Yau, Raja Ahsan Aftab, Renukha Sellappans, Bee Kim Tan
pp. 1–15 · DOI: 10.18549/PharmPract.2025.4.3317 · Published 11 November 2025
Background: Inadequately managed dry eye disease (DED) causes complications and poor quality of life. Studies exploring the role of community pharmacists (CP) in identifying and managing DED are scarce. We aimed to deter…
Article
Perception and attitudes of pharmacists to continuous professional development-based mandatory relicensing: A Cross-sectional study
Mohammad Abu Assab, Hamza Alhamad, Marah Alqaisi, Fares Albahar, Muna Barakat, Hanadi Abu Assab
pp. 1–8 · DOI: 10.18549/PharmPract.2025.4.3318 · Published 4 November 2025
Background: The changing role of pharmacists requires ongoing professional development to support continual learning, enhance competency, and improve patient care. The objective of this study was to assess Jordanian phar…
Article
A new approach towards developing a smart and multifunctional peptide-based drug delivery system for selective targeting and treatment of invasive/metastatic breast cancer.
Walhan Alshaer, Hamdi Nsairat, Malek Zihlif
pp. 3172 · DOI: 10.18549/PharmPract.2025.4.3172 · Published Oct-Dec 2025
Cancer remains one of the leading causes of morbidity and mortality worldwide. Breast cancer is the most frequently diagnosed cancer and causes cancer-related deaths in women. In cancer, targeted drugs are often divided …
Article
Somatostatin Therapy and Surgical Outcomes in Acromegaly: Insights From a Systematic Review and Meta-analysis
Jumanah Althomali, Sarah Ahmed, Shouq Aljohani, Sohaila Ahmed, Sahar Abdulrahman, Saeed Al-beshi, Dania Othman, Meshael Alghaihab, Maali Hamdan, Shaden Alnasr, Raghad Alshammari, Reema Aljasser, Rawan Sajdi, Arwa Alahmari, Futun Alotaibi
pp. 3218 · DOI: 10.18549/PharmPract.2025.4.3218 · Published 11 November 2025
The management of acromegaly, a chronic hormone disorder characterized by excessive growth hormone (GH) secretion, remains a subject of debate. This systematic review and meta-analysis aim to evaluate the impact of preop…
Article
Investigation of the gut microbiota and adverse reactions associated with the combined bifidobacterium, lactobacillus, enterococcus and bacillus cereus tablets and rabeprazole in patients suffering from gastroesophageal reflux
Nannan Yin, Xuan Zhao, Lihong Shi
pp. 3225 · DOI: 10.18549/PharmPract.2025.4.3225 · Published 13 November 2025
Objective: To explore the effect of proton pump inhibitor (PPI) Rabeprazole combined with Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets (CBLEB) in gastroesophageal reflux disease (GERD…
Article
The gene expression alterations in chronic hypoxic PANC-1 pancreatic cancer cell line
Malek Zihlif, Heba A Khader, Layali Younis, Ahmad Sharab, Farah Tahboub, Luai Hasoun, Hamzah Hajaj, Zaid Alawneh, Ahmad R. Alsayed
pp. 3238 · DOI: 10.18549/PharmPract.2025.4.3238 · Published 7 November 2025
Aim: Cancer cells divide excessively, resulting in overpopulation and hypoxia. Tumor hypoxia drives tumor development and therapeutic resistance. Hypoxia dominates pancreatic tumor microenvironments. This study aimed to …
Article
Pharmacists' knowledge, attitudes, and practices of dispensing antibiotics without a prescription
Anan S. Jarab, Walid Al-Qerem, Karem H. Alzoubi, Shrouq R. Abu Heshmeh, Ahmad Nor Aldin Alzoubi, Alaa H. Alsajri, Shadan W. Al-Hishma, Yazid Al Hamarneh, Yousef Mimi, Rania E. Ghanem, Maher Khdour
pp. 3250 · DOI: 10.18549/PharmPract.2025.4.3250 · Published 15 November 2025
Background: Antibiotics have become some of the most widely used and essential tools in the healthcare system, with the advantage of saving millions of lives. However, the overuse and misuse of antibiotics led to the eme…
Article
Prevalence and management of drug–drug interaction of nirmatrelvir/ritonavir in patients with COVID-19: A real-life practice in Thailand
Pongsakorn Charoenviwattanakij, Wichai Santimaleeworagun, Watsa Charoenwaiyachet, Chotirat Nakaranurack
pp. 3271 · DOI: 10.18549/PharmPract.2025.4.3271 · Published 29 October 2025
Background: Nirmatrelvir/ritonavir is a novel oral antiviral medication for coronavirus disease 2019 (COVID-19). Most international guidelines recommend nirmatrelvir/ritonavir for treating patients with mild to moderate …
Article
Use of proton pump inhibitors in patients with acute coronary syndrome treated with dual antiplatelet therapy: a tertiary care observation
Areerut Leelathanalerk, Peeraya Sriphong, Kamonchanok Wannakam, Chalita Pumkhun, Chawika Rerksansern, Kritsanee Saramunee
pp. 3290 · DOI: 10.18549/PharmPract.2025.4.3290 · Published 11 November 2025
Background: Dual antiplatelet therapy (DAPT) reduces the incidence of ischemic events and increases the risk of gastrointestinal bleeding (GIB). Proton pump inhibitors (PPIs) can be utilized to mitigate and prevent this …
Article
The impact of an educational intervention on medication adherence self-efficacy in patients with type 2 diabetes in hail, Saudi Arabia
Abdullah Mohammad Alshammari, Mohamed Hassan Elnaem, Siew Chin Ong
pp. 3293 · DOI: 10.18549/PharmPract.2025.4.3293 · Published 13 November 2025
Introduction: Medication adherence self-efficacy is vital for improving therapeutic outcomes in patients with Type 2 Diabetes Mellitus (T2DM). Limited data exist on medication adherence self-efficacy among T2DM patients …
Article
Public habits and attitudes toward disposal of unused medications and views on advanced medication take-back programs in UAE: A cross sectional study
Nadia Al Mazrouei, Nour Kousa, Malak Mohammed Al Baldawi, Aisha A. A. Alsaeed, Rana Ibrahim, Karem H. Alzoubi, Mohamed H Ahmed, Safaa Badi
pp. 3303 · DOI: 10.18549/PharmPract.2025.4.3303 · Published Oct-Dec 2025
Objective: This study aimed to assess the general population’s habits and attitudes toward disposing of expired and unused medications and evaluate their awareness of advanced medication take-back programs using an appli…
Article
Knowledge and Attitudes of the Healthcare Providers in the United Arab Emirates toward the Reports of the Pharmacogenomics in Cardiovascular Disease Randomized Clinical Implementation “EmHeart” study: A Cross sectional study
Zeina N. Al-Mahayri, Emad Masuadi, Mohammad Al-Saadi, Khalid AlMaamari, Omar Al Zaabi, Saoud Altamimi, Khalifa Al-Seiari, Nasser Al-Shamsi, Hajar Alktifan, Maryam Alktifan, Basma Beiram, Bassam R. Ali, Azhar T. Rahma
pp. 3305 · DOI: 10.18549/PharmPract.2025.4.3305 · Published Oct-Dec 2025
Introduction: The “EmHeart” study, a randomized multicenter clinical trial, was launched in 2021 to investigate the implementation of pharmacogenomics (PGx) in the UAE, with a focus on cardiovascular patients taking clop…
Article
Results of social research on assessing the needs for pharmaceutical personnel
Sabina Seidaliyeva, Klara Shertaeva, Gulnara Utegenova, Sholpan Akhelova, Mariya Anartayeva, Bibigul Doltayeva, Galiya Umurzakhova, Maria Bubeshova, Aizat Seidakhmetova, Kairat Zhaldybayev
pp. 3313 · DOI: 10.18549/PharmPract.2025.4.3313 · Published 30 October 2025
The pharmaceutical industry in Kazakhstan faces increasing demand for qualified personnel caused by rapid technological developments, changes in the regulatory environment and the growing role of inter-organizational col…
Article
Skeletal effects of nilotinib on prepubertal and pubertal rats
Yasin I. Tayem, Wael A. Nasr El-Din, Aisha N. Rashid, Sindhan Veeramuthu, Manal A. Othman
pp. 3320 · DOI: 10.18549/PharmPract.2025.4.3320 · Published Oct-Dec 2025
Background: Nilotinib belongs to a group of anti-cancer drugs called tyrosine kinase inhibitors (TKIs), which are currently the mainstay treatment of chronic myeloid leukemia (CML). Objectives: In this study, we aimed to…
Article
Oral anticoagulant-proton pump inhibitor interactions: A pharmacovigilance assessment using disproportionality and interaction analyses
Kannan Sridharan, Gowri Sivaramakrishnan
pp. 3326 · DOI: 10.18549/PharmPract.2025.4.3326 · Published Oct-Dec 2025
Objective: Oral anticoagulants operate within a narrow therapeutic window, with upper gastrointestinal bleeding representing a significant safety concern. While proton pump inhibitors (PPIs) have demonstrated gastroprote…
Article
Prospective Evaluation of Antiplatelet and Anticoagulant Use: Data from a Multidisciplinary Teaching Hospital in the United Arab Emirates
Mohamed Elgendy Ahmed, Myalil Lucca Jisha, Menon Vineetha
pp. 3330 · DOI: 10.18549/PharmPract.2025.4.3330 · Published 18 November 2025
Background: Antiplatelet and anticoagulant therapies are pivotal in managing cardiovascular and thromboembolic disorders, significantly reducing thrombotic events and improving patient outcomes. Despite their clinical be…
Article
Morbidity and mortality rates in premature infants treated with aminoglycosides in neonatal intensive care units: A comparative study
Lujain Khalid Khan, Walid A. Al-Qerem, Shakir D. AlSharari, Fawaz Alasmari
pp. 3342 · DOI: 10.18549/PharmPract.2025.4.3342 · Published 11 November 2025
Objective: Aminoglycosides are used as first-line defense antibiotics in the Neonatal Intensive Care Unit (NICU) for the treatment of sepsis, meningitis, neonatal pneumonia, and endocarditis. However, they pose negative …
Article
The knowledge of antimicrobial resistance: a survey in the community pharmacies of north-west Italy
Francesca Baratta, Ilaria Stura, Lorenzo Ravetto Enri, Marco Parente, Giuseppe Migliaretti, Paola Brusa
pp. 3347 · DOI: 10.18549/PharmPract.2025.4.3347 · Published 13 November 2025
Background: Antimicrobial Resistance (AMR) occurs in nature, but the inappropriate and excessive use of antimicrobials, and poor infection prevention, have all contributed to the increasing incidence of this phenomenon. …
Article
Silver nanoparticle microemulsion as a novel localized antimicrobial therapy: Formulation, efficacy, and safety evaluation
Niratcha Chaisomboon, Teerawat Nitichaikulvattana, Hathairat Lekatana, Chanida Chantim, Nattakanwadee Khumpirapang, Prayuth Poowaruttanawiwit
pp. 3354 · DOI: 10.18549/PharmPract.2025.4.3354 · Published 29 October 2025
Background: Amidst the growing challenge of antimicrobial resistance, there is an increasing demand for localized antimicrobial delivery systems with enhanced efficacy and safety profiles. Silver nanoparticles (AgNPs) ha…
Article
Development and validation of a predictive scoring tool for family violence risk assessment
Samaphorn Theinkaw, Prayuth Poowaruttanawiwit
pp. 3356 · DOI: 10.18549/PharmPract.2025.4.3356 · Published 11 November 2025
Background: Family violence remains a critical global public health concern, often underreported and undetected in clinical settings. Early risk identification is vital yet hindered by reliance on unstructured clinical j…
Article
The effectiveness of Pharmacist-driven Medication optimization: A Retrospective study on Warfarin and Digoxin
Anas Abed, Mohammad Abu Assab, Maha Basheer Al-Jaghbeer, Ahlam Asa'd Abdelaziz, Enas Almanasreh, Wael Abu Dayyih, Badriyah S. Alotaibi
pp. 3360 · DOI: 10.18549/PharmPract.2025.4.3360 · Published 13 November 2025
Background: Warfarin and digoxin are essential for managing cardiovascular conditions but carry risks of adverse drug reactions (ADRs) due to their narrow therapeutic indices, particularly in patients on concurrent thera…
Article
Development of a new spectrophotometric method for the determination of flavonoids in herb of red clover (Trifolium pratense L) and zigzag clover (Trifolium medium L)
Alexander Vladimirovich Nikulin, Fedor Valerievich Radus, Ludmila Ilyinichna Fedorina, Yulia Alexandrovna Efimova, Mikhail Alexandrovich Lazov, Elena Valeryevna Mironova, Darya Aleksandrovna Trashchenkova, Ekaterina Anatolevna Dorovskikh, Ekaterina Vyacheslavovna Sergunova, Natal'ya Vladimirovna Bobkova, Elena Nikolaevna Kostikova, Sergey Viktorovich Lutsenko, Valeriya Alexandrovna Savina, Olga Georgievna Potanina, Rimma Aleksandrovna Abramovich, Tatiana Yurievna Kovaleva
pp. 3384 · DOI: 10.18549/PharmPract.2025.4.3384 · Published 12 November 2025
Objective: Medicinal plants containing flavonoids are attracting increasing interest of researchers due to their complex therapeutic effects on the human body. Such medicinal plants include representatives of the genus C…
Article
Factors associated with adverse drug reactions among residents in nursing home
Ardiana Murtezani, Dion Haliti, Shkurta Rrecaj–Malaj, Zana Ibraimi
pp. 3391 · DOI: 10.18549/PharmPract.2025.4.3391 · Published 19 November 2025
Background and Aim: Adverse drug reactions (ADRs) are a significant public health concern, especially in the elderly. Factors like multimorbidity, polypharmacy, frailty, and age-related changes in drug metabolism increas…

Review Article

Review
Optimizing Antenatal Care: A Systematic Review and Meta-Analysis on How Scheduling Influences Fetal Outcomes
Reem Alraya, Amal AlZahrani, Ghufran Alruwaili, Ruba Alruwaithi, Rabab Alnakhli, Lina Bazeeb, Afrah Alreshidi, Bayan Aldeligan, Saja Farhan, Turki Shafi, Mashael Farhan, Gadeer Alshmmari, Ahmed Alruwaili, Mujtaba Mohammed, Dhya Alnahawi
pp. 1–19 · DOI: 10.18549/PharmPract.2025.4.3199 · Published 11 November 2025
Introduction: Maternal and neonatal health outcomes are significantly influenced by the presence or absence of prenatal care. This meta-analysis aims to comprehensively evaluate the impact of booked and unbooked pregnanc…
Review
The future of pediatric oncology: Comprehensive review of causes, mortality, and treatment strategies
Jana Farrash, Nujud Alessa, Fatima Almuammar, Rana Almuqati, Yara Alghamdi, Fatimah Alsultan, Areej A. Alghamdi, Luluh Alomaym, Maryam T. Alotaibi, Sara Alqahtani, Refal Aljali, Leen Alziad, Abdullah Alzahrani, Abdulrahman Akshah, Faris Mohammed
pp. 1–15 · DOI: 10.18549/PharmPract.2025.4.3215 · Published 11 November 2025
Pediatric oncology is confronting rising cancer rates among children, which poses a significant global health challenge. This review article delves into the multifaceted aspects of pediatric cancers, including their etio…
Review
Unlocking the potential: Exploring antimicrobial properties in Asteraceae, Apiaceae, and Rosaceae plant species from Kazakhstan
Baiken Baimakhanova, Amankeldi Sadanov, Irina Ratnikova, Gul Baimakhanova, Erik Shorabaev, Zere Turlybaeva, Assya Balgimbaeva, Zhanar Nurgaliyeva, Roza Seisebayeva, Gulshat Kulniyazova, Sarzhan Kapassov, Aknur Turgumbayeva, Gulnaz Seitimova, Zhanserik Shynykul
pp. 1–26 · DOI: 10.18549/PharmPract.2025.4.3279 · Published 30 October 2025
Kazakhstan’s rich botanical landscape harbors a treasure trove of medicinal knowledge and practices, deeply rooted in its terrain and cultural heritage. This review explores the diverse flora of Kazakhstan, highlighting …
Review
Increased Global Burden of Pediatric Infectious Diseases: Updates on Diagnosis, Management, and Vaccination Strategies
Turki H Alsayyali, Atyaf Mohammed, Razan Saud, Zainab Alshaikh, Rakan Alanazi, Sama Alanazi, Shaden Alfayadh, Nouf Aldakhail, Asma Alshammari, Ebtihal Alhawsawi, Rawan Alanazi, Shatha Alsulaiman, Rana Almutairi, Mashael Alshammari, Hatim Alsulaymi
pp. 3175 · DOI: 10.18549/PharmPract.2025.4.3175 · Published 7 November 2025
The increasing global burden of pediatric infectious diseases poses a significant public health concern, particularly in low- and middle-income countries. This review article provides an overview of major pediatric infec…
Review
Hematologic Manifestations in Systemic Lupus Erythematosus: A Systematic Review of Clinical Patterns, Prognostic Implications, and Epidemiology
Abdullah Al-Sheef, Luluh Khalid, Raneem Almutairi, Renad Alhajlah, Nora Alotaibi, Shaden Almutairi, Abdullah Hamdan, Khalid Al-Moqader, Amjad Al-Moqader, Shahad Alelaiw, Maryam Alfehaid, Maha Alfayad, Sarah Jabbari, Wasan Alenazi, Abdullah Shaher
pp. 3179 · DOI: 10.18549/PharmPract.2025.4.3179 · Published Oct-Dec 2025
Systemic lupus erythematosus (SLE) is a long-term autoimmune disease that has various clinical manifestations, the hematologic abnormalities among which are frequent and vary in clinical severity. These may cause simple …
Review
MicroRNA Regulation in Cancer: Insights into Diagnosis, Prognosis, and Treatment
Ibtihaj Alrehaili, Norah Alrashoud, Rawaeb Almutairi, Lama Alqahtani, Nour Alhatm, Aseelah Almutairi, Asma Alghamdi, Azhar Barnawi, Kharsan Alyami, Hanin Alghamdi, Jamilah Algasem, Reham Alshahrani, Lubna Aljaddua, Mozoun Alahmari, Lama Alqahtani
pp. 3205 · DOI: 10.18549/PharmPract.2025.4.3205 · Published 29 October 2025
MicroRNAs (miRNAs) are tiny, non-coding RNA molecules that are pivotal in regulating cell growth, development, cell cycle, and programmed cell death. Alterations in miRNA expression, caused by various mechanisms such as …
Review
Transforming Emergency Care: An In-Depth Review of the Latest Advances in Emergency Medications
Rahaf Alshahrani, Raghad Alsayed, Reem Saleem, Mada Alahmadi, Bayan Aldeligan, Jumanah Althomali, Hind Aljedaani, Najla Alotaibi, Shahad Alshahrani, Nermeen HossamEldin, Amal Alqahtani, Khawlah Alsaqiti, Arwa Almalki, Ghadeer Almethen, Shatha Almutairi
pp. 3219 · DOI: 10.18549/PharmPract.2025.4.3219 · Published 4 November 2025
The specialty of medicine that deals with primary diagnosis and immediate treatment of sudden illness and/or accidental injury is called emergency medicine (EM). EM is an extremely crucial and dynamic specialty of health…
Review
Efficacy and long-term impact of HPV vaccination strategies: A Scoping review of clinical trials and follow-up studies
Sozan M. Abdelkhalig
pp. 3312 · DOI: 10.18549/PharmPract.2025.4.3312 · Published 29 October 2025
Background: Human papillomavirus (HPV) is a leading cause of cervical cancer and other HPV-related cancers globally. Vaccination against HPV has proven to be a pivotal intervention in reducing the burden of these disease…