Volume 51, Issue 4S

Hemlata Dewangan, Raj Kumar Tiwari, Vikas Sharma, Shiv Shankar Shukla, Trilochan Satapathy, Ravindra Pandey

pp. s522–s530 · DOI: 10.5530/ijper.51.4s.79 · 2017

Diabetes mellitus is classified into two major types, Type 1 (Insulin Dependent Diabetes Mellitus) and Type 2 (Non-Insulin Dependent Diabetes Mellitus). In world about 90% of diabetes patients are of Type 2 diabetes. The…

Abhishek Ajmera, Parshuram Shendge

pp. s531–s538 · DOI: 10.5530/ijper.51.4s.80 · 2017

All drug discovery methods, right from ‘trial-and-error’ approach to modern rational synthesis of drugs, make use of animals to check for efficacy and toxicity of compounds. This results in millions of animals being sacr…

Md Wasim Hussain, Poonam Kushwaha, Md. Azizur Rahman, Juber Akhtar

pp. s539–s547 · DOI: 10.5530/ijper.51.4s.81 · 2017

Objective: Objective was designed to prepare, develop and evaluate fast dissolving films (FDFs) for oro-buccal drug delivery of chlorpromazine. Background: The drug delivery through oro-buccal mucosa is very interesting …

Bala Vishnu Priya Mukkala, Murthy TEGK, Prameela Rani A

pp. s548–s558 · DOI: 10.5530/ijper.51.4s.82 · 2017

Objective: The aim of the present research work was to optimize the process of Methylphenidate Hydrochloride (HCl) Extended releasse (ER) pellets based on Quality by Design (QbD) principles. Materials and methods: Wurste…

Gagandeep Kaur, Saurabh Sharma

pp. s559–s565 · DOI: 10.5530/ijper.51.4s.83 · 2017

Objective: Renal failure in majority of population is considered to be idiopathic. Heavy metals like lead in drinking water are usually the hidden cause of these renal consequences. Thus, this study has been designed to …

Anjna Sharma, Asmita Magotra, Utpal Nandi, Gurdarshan Singh

pp. s566–s570 · DOI: 10.5530/ijper.51.4s.84 · 2017

Objective: Poor water solubility, P-glycoprotein (P-gp) efflux property and substrate of CYP3A lead to low oral bioavailability that limit the oral use of paclitaxel, a key anticancer drug. Though several formulation app…

Harsha Kamath, A Sivakumar

pp. s571–s579 · DOI: 10.5530/ijper.51.4s.85 · 2017

Purpose: The present study is intended to develop and evaluate oil in water (O/W) microemulsion based formulation for gliclazide as oral drug delivery system for the treatment of diabetes mellitus. Gliclazide, having sul…

Swati Talele, Preetam Nikam, Braja Ghosh, Chaitali Deore, Ashwini Jaybhave, Anil Jadhav

pp. s580–s587 · DOI: 10.5530/ijper.51.4s.86 · 2017

Background: Transdermal delivery of drug is promising but challenging system is available for local as well as systemic effect of drug. The prolonged residence of drug formulation in the skin is important for transdermal…

Vishwajeet Sampatrao Ghorpade, Kailas Krishnat Mali, Remeth Jacky Dias, Vijay Daulatrao Havaldar, Ganesh Shankar Raut

pp. s588–s600 · DOI: 10.5530/ijper.51.4s.87 · 2017

Objective: The present investigation is aimed at development and optimization of a pH independent controlled release matrix tablet containing mannitol based quaternary inclusion complex (QIC) of domperidone (DOM) for the…

Prakash Katakam, Phalguna Yadagiri

pp. s601–s606 · DOI: 10.5530/ijper.51.4s.88 · 2017

Objectives: objective of present research was to formulate and evaluate nanospheres of selected anticancer drugs, viz., Capecitabine (CPN), Tamoxifen (TAM) and Doxorubicin (DXO). The adverse effects associated with antic…

Shriram Ramesh Pethakar, Pramod Jayadevappa Hurkadale, Ravindra Durdundayya Hiremath

pp. s607–s614 · DOI: 10.5530/ijper.51.4s.89 · 2017

Introduction: Cucumis sativus fruits are claimed for their antiurolithiatic activity in traditional system of medicine. Materials and Methods: Present study was undertaken to evaluate lithotryptic effect using hydro-alco…

Praveena P, Jethinlalkhosh JP, Victor Arokia Doss

pp. s615–s622 · DOI: 10.5530/ijper.51.4s.90 · 2017

Objective: This study was undertaken due to the popular belief in most of the Asian countries that the unripe fruit of Carica papaya L if eaten during early months of pregnancy can lead to miscarriage. The aim of the pre…

Naveen kumar C, Jayalakshmi G, Chidambaram R, Srikumar R

pp. s623–s630 · DOI: 10.5530/ijper.51.4s.91 · 2017

Background: Bioproducts of mushrooms Ganoderma lucidum have multi beneficial effects for human welfare. Objectives: The aim of the present study was to evaluate antifungal activity of Ganoderma lucidum against the biofil…

Hong Duan, Ke Feng Zhai, Wen Gen Cao, Gui Zhen Gao, Ling Ling Shan, Liang Zhao

pp. s631–s636 · DOI: 10.5530/ijper.51.4s.92 · 2017

Background: To develop the optimal extractive technique of the Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook in the Fengshiding dropping pill. Methods: Single factor experiments were carried out on the …

Pınar Erecevit, Sevda Kırbağ

pp. s637–s644 · DOI: 10.5530/ijper.51.4s.93 · 2017

Objective: In this work; phytochemical parameters (fatty acid, vitamin, phytosterol, flavonoid and resveratrol contents, and antioxidant activities antimicrobial activities) of Pisum sativum (pease) extracts prepared wit…

Aniruddha Mukherjee, Kalyan K Sen, Sugato Banerjee

pp. s645–s652 · DOI: 10.5530/ijper.51.4s.94 · 2017

Metabolic syndrome (MetS) is associated with high blood glucose, insulin resistance, dyslipidemia, central obesity, and hypertension. There is clinical evidence of the coexistence of depression and MetS, however, pathway…

Rini Thainery Padinchare Veetil, Janardhan Kamath, Uday Venkat Mateti

pp. s653–s660 · DOI: 10.5530/ijper.51.4s.95 · 2017

Objectives: To assess the impact of patient education on Interdialytic Weight Gain (IDWG) and Blood Pressure (DBP) in patients undergoing hemodialysis (HD). Materials and Methods: A Quasi experimental Pre and Post study …

Shaikh Shahinur Rahman, Nilufar Yasmin, Abu Taher Mohammad Mizanur Rahman, Akteruz zaman, Mohammad Hafizur Rahman, Shakh Mohammad Abdur Rouf

pp. s661–s666 · DOI: 10.5530/ijper.51.4s.96 · 2017

Background: The optimal effective and safe dose of alloxan for inducing stable diabetes in rats has been long arguable. Lower doses can result in auto-reversion from diabetogenic state to normal state. On the other hand,…

Maryam Nakhjavani, Farshad H. Shirazi

pp. s667–s674 · DOI: 10.5530/ijper.51.4s.97 · 2017

Introduction: A key challenge in fighting against cancer is cancer recurrence and resistance. Apart from the advances in the field of cancer treatment, the outcome is not still as high as expected. This may be partly due…

Kowalczyk Adam, Bodalska Agnieszka, Boszkiewicz Kamila, Karlowicz Bodalska Katarzyna

pp. s675–s678 · DOI: 10.5530/ijper.51.4s.98 · 2017

Context: Among cancer patients receiving chemotherapy, there is a growing trend to use self-medication. Many of them take preparations sold over the counter (OTC) and dietary supplements containing plant raw materials. A…