Volume 52, Issue 1

Original Article

1. Article

   Revisiting Concepts, Attitudes and Expectations of Brazilian Pharmacists to the Practice of Pharmaceutical Care: A Qualitative Perspective

   Claudia Fegadolli, Afonso Miguel Cavaco, Débora Cristina Fonseca

   pp. 1–9 · DOI: 10.5530/ijper.52.1.1 · 2018

   Background: Research has shown advancements in pharmaceutical care services to the population, with a change in practitioners’ professional behaviors. Objective: This study aimed to assess present attitudes, expectations…

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2. Article

   A Study on the Perceived Gap in Between Industry and Academia with Reference to the Curriculum of Post-Graduate Courses In Pharmaceutical Sciences in india

   Gouri Palsokar, Madhukar Tajne

   pp. 10–20 · DOI: 10.5530/ijper.52.1.2 · 2018

   The rapid growth of pharmaceutical industry in India has resulted into an increased demand for skilled and trained graduates and post-graduates in pharmaceutical sciences over the last decade. Over a period of time due t…

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3. Article

   Research Involvement of Pharmacy Faculties in India

   Prasanna R Deshpande, Vikas R. Chandrakar, Kiran Bhusare, Tarachand Lalwani, M Naga Lakshmi Prasanna, Ashish Kanhed, Atmaram P Pawar

   pp. 21–31 · DOI: 10.5530/ijper.52.1.3 · 2018

   Objective: The contribution of Indian pharmacy research is unremarkable in the world. Hence, we aimed to determine the research involvement and research productivity of Indian pharmacy faculties. Methods: A questionnaire…

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4. Article

   Curcumin: The Molecular Mechanisms of Action in Inflammation and Cell Death during Kainate-Induced Epileptogenesis

   Yow Hui-Yin, Nurulumi Ahmad, Norazrina Azmi, Mohd Makmor-Bakry

   pp. 32–41 · DOI: 10.5530/ijper.52.1.4 · 2018

   Background: Recent preclinical studies demonstrated the potential antiepileptogenic effect of curcumin. Its molecular pathways in modulating epileptogenesis remain unclear. Objectives: This study investigated the epilept…

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5. Article

   Pharmacokinetics and Tissue Distribution of PLGAPLL-PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS

   Yonglu Wang, Yang Li, Jiwei Liu, Xueming Li

   pp. 42–53 · DOI: 10.5530/ijper.52.1.5 · 2018

   Objective:A sensitive, rapid and reliable LC-MS/MS method was developed for simultaneously determination of daunorubicin (DNR) and tetrandrine (Tet) in rat plasma and tissues. Methods: The pharmacokinetics and tissue dis…

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6. Article

   Pharmaceutical Formulation and Biochemical Evaluation of Atorvastatin Transdermal Patches

   Tamer M. Shehata, Omar M.M. Mohafez, Hamza N. Hanieh

   pp. 54–61 · DOI: 10.5530/ijper.52.1.6 · 2018

   Atorvastatin is a lipid lowering agent and widely used to treat hypercholestermia. However following oral administration, the bioavailability of the drug is only 12% due to extensive first pass metabolism. The aim of the…

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7. Article

   Development and Evaluation of High Oxaliplatin Loaded CS-g-PNIPAAm Co-Polymeric Nanoparticles for Thermo and pH Responsive Delivery

   Archana Sidagouda Patil, Anand Panchakshari Gadad

   pp. 62–70 · DOI: 10.5530/ijper.52.1.7 · 2018

   Background: Chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) co-polymer was reported as a much efficient drug carrier but it shows very low percentage of drug loading in to the nanoparticles. Objective: The objectiv…

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8. Article

   Solid State Characterization and Tableting Studies of Ethanol Based Cocrystals of Fenofibrate with Nicotinamide

   Amol Somanath Shete, Vishwajeet V Khandagale, Srinivasa M Murthy, Adhikrao Vyankatrao Yadav, Sfurti Shamling Sakhare, Rajendra Chandrashekhar Doijad

   pp. 71–77 · DOI: 10.5530/ijper.52.1.8 · 2018

   Objectives: The pharmaceutical cocrystals can be defined as dissociable “API-excipient” molecular complexes or Co-crystals are solids that are crystalline materials composed of two or more molecules in the same crystal l…

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9. Article

   Chemo Preventive Effect of Rutin Against N-Nitrosodiethylamine-Induced and PhenobarbitalPromoted Hepatocellular Carcinoma in Wistar Rats

   Yadala Prapurna Chandra, A.H.M. Viswanathswamy

   pp. 78–86 · DOI: 10.5530/ijper.52.1.9 · 2018

   Background: In recent years, a large number of natural compounds have been identified and proved to have a potential cancer chemopreventive importance due to their strong antioxidant and cytotoxic activities. Objective: …

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10. Article

    Effect of Canscora decussata Extract against the Neurochemical and Behavioral Changes Induced by 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine in Mice

    Chitra V, Manasa K, Tamilanban T, Narayanan J

    pp. 87–93 · DOI: 10.5530/ijper.52.1.10 · 2018

    Objective: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced parkinsonism is a widely accepted animal model for screening the drugs used in Parkinson’s disease (PD). In the present study, the neuroprotective ef…

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11. Article

    Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

    Sema Misir, Yuksel Aliyazicioglu, Selim Demir, Ibrahim Turan, Serap Ozer Yaman, Orhan Deger

    pp. 94–100 · DOI: 10.5530/ijper.52.1.11 · 2018

    Objective: Propolis is an important bee product, rich in polyphenolic compounds. It has antitumoral, antioxidant, antimutagenic, and other useful activities. Biological activities of propolis are generally attributed to …

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12. Article

    Protective Effect of A2B Receptor Antagonist (TRP 1) on Acetic Acid Induced Ulcerative Colitis in Rats: in vitro, in vivo and in silico Methods

    Praveen Kumar Pasala, Ramesh Alluri, Sri Chandana Mavulati, Raghu Prasad Mailavaram, Khasim Shaik, Prasad Konduri

    pp. 101–109 · DOI: 10.5530/ijper.52.1.12 · 2018

    Aim: Present study was elucidate the protective effect of pyridinone derivatives such as 7-amino-5-oxo-2- Phenyl-5H, 8H-dihydro-[1, 2, 4] triazolo [1, 5-α] pyridine - 6- carbonitril (TRP 1) by in vitro, in vivo and in si…

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13. Article

    Synthesis, Characterization, Antidepressant Activity and Docking Studies of Some Novel Indole Bearing Azetidinone Derivatives

    Deweshri Rajendrakumar Kerzare, Sunil Sugnomal Menghani, Pramod Bhujangrao Khedekar

    pp. 110–121 · DOI: 10.5530/ijper.52.1.13 · 2018

    Context: In general, indole bearing azetidinone derivatives are exhibiting various biological activities. The evaluation of pharmacological potential of the indole bearing azetidinone derivatives as antidepressant agent …

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14. Article

    Novel Potent Inhibitors of Plasmodium vivax Dihydrofolate Reductase: An in silico Antimalarial Drug Discovery

    Singh Pushpendra, Prem Prakash Kushwaha, Kumar Shashank

    pp. 122–134 · DOI: 10.5530/ijper.52.1.14 · 2018

    Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is on…

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15. Article

    Synthesis and Characterization of 2-phenyl-5- (1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol4-yl) - 1, 3, 4-oxadiazole Scaffolds for Assessing Their Medicinal Potentials

    Krishna Prasad Chennapragada, Venkata Sathya Machiraju Palagummi

    pp. 135–145 · DOI: 10.5530/ijper.52.1.15 · 2018

    Objective:The present research is aimed at the discovery and development of 1-phenyl-3- (3,4,5-trimethoxyphenyl)-1H-pyrazole derivatives as a series of novel 1, 3, 4-oxadiazoles (7a-7h) through iodine-catalyzed oxidative…

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16. Article

    The Effect of Aminophylline on Quinidine Passage into the Central Nervous System of Rats

    Velibor Vasović, Nebojša Stilinović, Saša Vukmirović, Ivan Mikov, Jelena Ćalasan, Momir Mikov

    pp. 146–150 · DOI: 10.5530/ijper.52.1.16 · 2018

    Background and Objective: There is significant interest in mutual influence of substances during their passage into the central nervous system (CNS). Quinidine is a drug which can achieve significant concentration in CNS…

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17. Article

    Development of Rapid and Validated RP-HPLC Method for Concurrent Quantification of Rosuvastatin and Aspirin form Solid Dosage Form

    Mahesh Attimarad, Ahmed Alkadham, Mohammed Hashem Almosawi, Katharigatta Narayanaswamy Venugopala

    pp. 151–158 · DOI: 10.5530/ijper.52.1.17 · 2018

    Background: Combination of aspirin and rosuvastatin has been successfully used for the treatment of hyperlipidemia. Objective: The objective of the project was to establish a rapid, accurate and precise liquid chromatogr…

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18. Article

    Comparative Shape and Electrostatic Study of Highly Potent and Selective CYP1B1 Inhibitor: Assessment of Active Site of CYP1B1 by Binding Mode Analysis Using Site Map Tool

    Mohd Usman Mohd Siddique, Barij Nayan Sinha, Venkatesan Jayaprakash

    pp. 159–165 · DOI: 10.5530/ijper.52.1.18 · 2018

    Introduction: The major aim of drug design and discovery is to minimize the time and cost of drug discovery process. Various molecules which are promised to be potential candidate during computational and preclinical stu…

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19. Article

    Cultural Adaptation and Examination of Metric Characteristics Shirom-Melamed Burnout Questionnaire (SMBQ) On a Sample of Pharmacists in Serbia

    Dragana Jocic, Nela Djonovic, Dusanka Krajnovic, Srdjan Stefanovic, Svetlana Stojkov, Sanja Kocic

    pp. 166–180 · DOI: 10.5530/ijper.52.1.19 · 2018

    Introduction: Due to the nature of work in pharmacies pharmacists may occur job burnout, which can affect the quality of health services. It is necessary to use validated instruments to test the burnout. One type of inst…

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