Volume 55, Issue 1S

Kajal Jagdish Bajaj, Bhagyashri Surendra Parab, Supriya Shrihari Shidhaye

pp. S1–S10 · DOI: 10.5530/ijper.55.1s.33 · 2021

Transdermal drug delivery has become a popular tool from last few years. It overcomes drawbacks which are encountered with the oral route. Though very few routes are as attractive as transdermal route, transport of drug …

Mahesh Gajanan Umbarkar

pp. S11–S28 · DOI: 10.5530/ijper.55.1s.34 · 2021

Aim: Formation of niosome by using non-ionic surfactant. The particle size of niosome must be required in the range in between 10 nm -100 nm. This is just due to avoid the aggregation of niosome and show proper result. M…

Illham Dhala, Tabassum Khan, Arati Prabhu

pp. S29–S47 · DOI: 10.5530/ijper.55.1s.35 · 2021

Alzheimer’s disease (AD) has emerged as a complex, multi-faceted, neurodegenerative disorder. Multiple mechanisms seem to play a part in its pathogenesis, including amyloid beta aggregation, cholinergic deficit, oxidativ…

Kuluvar Gouthamchandra, Heggar Venkataramana Sudeep, Amritha Raj, Illuri Ramanaih, Chandrappa Siddappa, Kodimule Shyamprasad

pp. S48–S55 · DOI: 10.5530/ijper.55.1s.36 · 2021

Objectives: The current study was carried out to demonstrate potential role of Turcuron, a standardized turmeric extract containing 8% Bisacurone to protect against non-alcoholic fatty liver disease (NAFLD). Methods: Hep…

Vinayak Shivamurthy Mastiholimath, Gauri Pradeep Mashelkar, Vinodkumar Shirshalappa Mannur, Panchaxari Mallappa Dandagi, Pukar Khanal

pp. S56–S65 · DOI: 10.5530/ijper.55.1s.37 · 2021

Objectives: The present study aimed to enhance the solubility of Oxcarbazepine by melt sono crystallization technique as well as increase its bioavailability. Materials and Methods: Tablets of Melt Sonocrystallized Oxcar…

Deepak Aswal, Tanuja Bisht

pp. S66–S74 · DOI: 10.5530/ijper.55.1s.38 · 2021

Aim: The aim of the present investigation was to increase the dissolution rate of Fluconazole by solid dispersion technique and then it was incorporated into the gel for better diffusion profile. Fluconazole, an imidazol…

Ayush Jaiswal, Senthil Venkatachalam, Anindita De, Bhavesh Namdev, Ravikumar Ramaswamy, Jawahar Natarajan

pp. S75–S86 · DOI: 10.5530/ijper.55.1s.39 · 2021

Aim/Background: Alzheimer’s disease (AD) is one of the most ominous diseases, leads dementia but highest unmet till today. The new strategy needed via repositioning due to the limitation of existing therapies. Valproic a…

Sfurti Sakhare, Sachin Dnyandeo Shinde, Adhikrao Venkatrao Yadav, Amol Somnath Shete

pp. S87–S99 · DOI: 10.5530/ijper.55.1s.40 · 2021

Aim: Ocular drug delivery is the most challenging and interesting goal in front of the pharmaceutical scientist. Ocular inflammation is the most commonly affecting disease of the eye. The objectives of present investigat…

Poornima Poornima, Sneh Priya

pp. S100–S111 · DOI: 10.5530/ijper.55.1s.41 · 2021

Aim and Objectives: The present study aimed to formulate and evaluate gastroretentive nanosponge loaded with lafutidine for a gastric ulcer to overcome the drawbacks of oral conventional dosage forms such as the inabilit…

Darshana Pravinchandra Panhale, Rishikesh Shankar Bachhav, Sheetal Bhaskar Gondkar

pp. S112–121 · DOI: 10.5530/ijper.55.1s.42 · 2021

Introduction: The present study was carried out to formulate and evaluate orodispersible tablets of Apremilast with a purpose of providing better patient compliance to geriatric, pediatric, impaired, travelling and non-c…

Subhabrota Majumdar, Suryakanta Swain, Muddana Eswara Bhanoji Rao, Puja Chakraborty, Sabya Sachi Das

pp. S122–S134 · DOI: 10.5530/ijper.55.1s.43 · 2021

Background: Acyclovir is a potent antiviral agent primarily used to treat viral infection in the eye, signified as Herpes Simplex Keratitis caused by Herpes Simplex Virus-1. But its applications are limited because of it…

Shabari Girinath Kala, Santhivardhan Chinni

pp. S135–S148 · DOI: 10.5530/ijper.55.1s.44 · 2021

Objectives: Raloxifene hydrochloride is used in the treatment of breast cancer which suffers from poor bioavailability problem i.e., only 2% due to excessive first pass metabolism. Development of a delivery system to ove…

Chathurappan Raja, V Sampath Kumar, Chinnakannu Jayakumar

pp. S149–S156 · DOI: 10.5530/ijper.55.1s.45 · 2021

Objectives: A systematic in-vitro study has been achieved to decide the stability of a selection of three presidential hydrotropes to decorate the obvious aqueous solubility of the sparingly water- soluble drug, mebendaz…

Mahesh Neurgaonkar, Shaila Veerappa Kothiwale

pp. S157–S163 · DOI: 10.5530/ijper.55.1s.46 · 2021

Aim: Controlled release (CR) local drug delivery (LDD) devices are useful in periodontitis management since they facilitate prolonged maintenance of high antimicrobial concentrations in the periodontal pockets. The study…

Patil Ramgonda, Rajashree Shashidhar Masareddy, Archana Patil, Uday Bolmal

pp. S164–S174 · DOI: 10.5530/ijper.55.1s.47 · 2021

Background: Oral bioavailability of Budesonide is 10% due to its extensive first pass metabolism, its high volume of distribution and 85-90% of protein binding. Protection of drug release in stomach and targeting drug to…

Shubhangi Pawar, Aman Upaganlawar, Chandrashekhar Upasani

pp. S176–S183 · DOI: 10.5530/ijper.55.1s.48 · 2021

Background: Streptozotocin (STZ) induced neuropathy is widely used preclinical model for diabetic neuropathy (DN). DN is majorly resulted due to nitrosative and oxidative stress induced by hyperglycemia. Phenolic acids a…

Sumeet Gupta, Hitendra Sharma, Mohamed Aly Morsy, Anroop Balachandran Nair, Kamalpreet Kaur, Satish Kumar, Meenakshi Dhanawat

pp. S184–S192 · DOI: 10.5530/ijper.55.1s.49 · 2021

Background: Plumeria obtusa L., a potential medicinal plant, is still unexplored for its anti-diabetic effect. The objective of this study was to examine the protective effect of Plumeria obtusa leaves extracts on insuli…

Haq Nawaz, Muhammad Aslam Shad, Mohibullah Shah, Adnan Amjad, Tanzila Rehman, Arif Mehmood, Dure Shahwar, Sabiha Tahir Abbasi

pp. S193–S201 · DOI: 10.5530/ijper.55.1s.50 · 2021

Aim/Background: The safe and complete extraction of flavonoids from plant material influenced by various factors has been ever challenging for the researchers. The study was planned to optimize the extraction of flavonoi…

Sadeq Khalid Alhag, Hamed Ali Ghramah, Lamya Ahmed Al-keridis, Fahd Abdu Al-Mekhlafi, Essam Hassan Ibrahim, Khalid Ali Khan

pp. S202–S208 · DOI: 10.5530/ijper.55.1s.51 · 2021

Background: Synthesis of silver nanoparticles (AgNPs) using green plants is important for biocompatibility, reduced hazards, green policy and eco-friendliness. Materials and Methods: In this study, a leaf extract of Sola…

Ujjwala Yadav Kandekar, Tejal Ramdas Abhang, Rohini R. Pujari, K.R. Khandelwal

pp. S209–S219 · DOI: 10.5530/ijper.55.1s.52 · 2021

Aim and Objectives: The aim of the current study is to isolate the starch from elephant foot yam (Amorphophallus paeonifolius) and investigate its potential as a disintegrant in tablet formulation as compare to standard …