Volume 57, Issue 3

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1. Article

   Combination of N-acetyl Cysteine and Thymoquinone Alleviates Hepatocellular Toxicities by Radiation and CCl4 Intoxication in SD Rats

   Shu Zhang, Shaohua Chen, Jingyi Wang, Qingyu Sun, Tahani Awad Alahmadi, Nandakumar Natarajan

   pp. 802–812 · DOI: 10.5530/ijper.57.3.98 · 2023

   Radiation and chemicals were the major clinical toxicants known to cause cellular damage during prognostic interventions in vivo. Cellular and molecular damages in the liver were the major causes for the hepatocellular i…

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2. Article

   Commercially Available Vitamin A Palmitate is Toxic and Teratogenic to the Tadpoles of Microhyla nilphamariensis (Anura: Microhylidae)

   Cuckoo Mahapatra, Pranati Naik, Mandakini Singh, Pratyush Paradarsita Mohapatra

   pp. 813–821 · DOI: 10.5530/ijper.57.3.99 · 2023

   Aim/Background: The present study, examined the impact of excess Vitamin A on feeding and pre-metamorphic tadpoles of Microhyla nilphamariensis to analyse its dose-dependent and stage-specific lethal and teratogenic effe…

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3. Article

   Binding Study of Monohydroxy Cucurbit[7]uril with Rhodamine B

   Karuppasamy Karpagalakshmi, Ramesh Prakash, Usha Govindaraj, Radhakrishnan Sathish Kannan, Lakshminarayanan Piramuthu, Narayanan Selvapalam

   pp. 822–826 · DOI: 10.5530/ijper.57.3.100 · 2023

   Background: Cucurbit[7]uril (CB[7]) is the most important host among the reported cucurbit[n]urils family members, because it exhibited unique molecular recognition with exceptional applications. The binding affinity of …

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4. Article

   Designing of Trifluoromethyl Substituted Pyrimidine Pharmacophore for Antiprostate Activity through a Collective Computational Approach

   Kalyani Asgaonkar, Sushruti Tanksali, Kshitija Abhang, Krishna Shevate, Shital Patil, Trupti Chitre

   pp. 827–837 · DOI: 10.5530/ijper.57.3.101 · 2023

   Background: Prostate cancer is one of the leading causes of death. Though many drugs are being used as effective anticancer agents resistance and side effects necessitates development of target selective and safe antican…

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5. Article

   2D-QSAR, Molecular Docking, and in silico Pharmacokinetics Analysis on N-substituted Urea and Thiourea Derivatives as Tankyrase Inhibitors for Implication in Cancer

   Hafiz A. Makeen, Mohammed Albratty

   pp. 838–853 · DOI: 10.5530/ijper.57.3.102 · 2023

   Objectives: Cancer is among four major Non-Communicable Diseases (NCD). Based on the World Health Organization (WHO), it is the biggest cause of mortality globally, claiming about 10 million lives in recent years. Tankyr…

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6. Article

   Fluorescence Detection of Etoposide Encapsulated Mesoporous Silica Nanoparticles by Environmentally Benign Bioanalytical HPLC Method and its Application to Pharmacokinetic Study

   Seema Saroj, Priya Shah, Sadhana J. Rajput

   pp. 854–863 · DOI: 10.5530/ijper.57.3.103 · 2023

   Introduction: Etoposide belongs to BCS Class IV suffering from solubility and permeability limitations. Thereby, hindering its bioavailability. Thereby, it is imperative to enhance its bioavailability by suitable formula…

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7. Article

   LC-MS/MS and NMR Studies for Identification and Characterization of Forced Degradation Products of Acalabrutinib

   Shweta Mishra, Ashlesha Chauhan

   pp. 864–872 · DOI: 10.5530/ijper.57.3.104 · 2023

   A new method named "Stability Indicating LC-MS/MS" was developed to make analysis on acalabrutinib and this method was stable for this anticancer drug. In acid, basic and oxidation the drug was shown instability on these…

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8. Article

   A Novel Bioanalytical Method for Simultaneous Determination of Olanzapine and Samidorphan in Human Plasma Using RP-HPLC

   Bonagiri Pavani, Narender Malothu, DSNBK Prasanth, Chakravarthi Guntupalli

   pp. 873–882 · DOI: 10.5530/ijper.57.3.105 · 2023

   Background: Schizophrenia patients are given with a combined medication of Olanzapine (OLA) and Samidorphan (SAM). A sensitive bioanalytical RP-HPLC technique has to be needed to analyse these drugs in biological samples…

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9. Article

   LC-MS/MS Analytical Method Development and Validation for Determining Vinamidinium HexafluoroPhosphate Impurity in Etoricoxib

   Satish Ganta, T Siva Rao, K Rama Srinivas, Pallapati Suman

   pp. 883–889 · DOI: 10.5530/ijper.57.3.106 · 2023

   Background and Aim: Process impurities may adversely affect the efficacy, excellent quality, and safety of pharmaceutical drugs. Ultimately, the purpose of this research work was to develop and validate a LC-MS/MS-based …

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10. Article

    Doxorubicin-induced Chronic Heart Failure is Alleviated by Gentiopicroside by Inhibiting Oxidative Stress and Inflammation

    Yujun Guo, Pan Gao, Wei Deng, Shujun Wang

    pp. 890–897 · DOI: 10.5530/ijper.57.3.107 · 2023

    Aim/Background: To study the Oxidative stress and inflammation inhibited by Gentiopicroside in chronic heart failure induced by doxorubicin. Materials and Methods: The procured healthy rats were first divided into four g…

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11. Article

    Impact of Educational Programs on the Knowledge and Attitude of Healthcare Professionals in Antimicrobial Stewardship

    Heni Lutfiyati, Jarir At Thobari, Nanang Munif Yasin, Zullies Ikawati

    pp. 898–904 · DOI: 10.5530/ijper.57.3.108 · 2023

    Introduction: The main concern related to antimicrobial use is the increasing incidence of resistance. Objective: This study aims to assess the impact of educational programs on the knowledge, attitudes, and practices of…

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12. Article

    Research on the "Problem-Centred Theory" Pedagogy to Improve the Clinical Thinking Ability of Medical Students

    Zhifu Wu, Liyun Hu

    pp. 905–910 · DOI: 10.5530/ijper.57.3.109 · 2023

    With the advent of the era of a knowledge economy, the teaching model of the problem-centred theory is widely concerned. This paper applies this teaching mode, takes the typical "abdominal pain" case as the problem centr…

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13. Article

    Knowledge, Attitude and Acceptance towards Coronavirus Disease 2019 (COVID-19) Vaccines among Healthcare Students of a Tertiary Care Teaching Hospital in South India: A Cross-sectional Study

    Indumathi Prabath, Porkodi Ayyar, Vivekraj Navabalan, Radhika Krishnan

    pp. 911–918 · DOI: 10.5530/ijper.57.3.110 · 2023

    Background: Coronavirus disease 2019 (COVID-19) has imposed a serious health impact afflicting millions of people and halting global progress significantly. Albeit vaccines for COVID-19 emerged as a potent approach to ov…

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14. Article

    Correlation Between Efficacy of Treatment with Anti-psychotics and Adherence in Schizophrenic Patients: A Cross-sectional Study in Saudi Arabia

    Sireen Abdul Rahim Shilbayeh, Fatimah Al-Dosari, Wasan Al-Sahabi, Modhi Al-Saif, Amal Al-Najjar, Nada Albogami

    pp. 919–929 · DOI: 10.5530/ijper.57.3.111 · 2023

    Background: Schizophrenic patients’ adherence to medication regimens can determine clinical outcome success. This study focuses on medication adherence and its correlation with the efficacy of anti-psychotics. The study'…

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15. Article

    Knowledge and Risk Factors Regarding Type 2 Diabetes among Saudi Population in Jeddah

    Amal Bakr Shori, Hadeel Alshareef

    pp. 930–936 · DOI: 10.5530/ijper.57.3.112 · 2023

    Aim: Public awareness of type 2 diabetes is a requirement for individuals and communities to help prevent the disease. Therefore, this study aimed to assess the level of knowledge and awareness of type 2 diabetes among d…

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