Volume 59, Issue 3

Smit Vijay Patkar, Atul Sherje

pp. 854–864 · DOI: 10.5530/ijper.20250454 · 2025

Cancer has been listed as the world's second-leading cause of death. Even with the significant progress made in recent years, advanced stages of the disease are still incurable. Conventional treatment options, such as su…

Yongjie Liu, Wenyue Mo, Huaqiang Ye, Meihua Bao, Zhen Long, Ruirui Kou, Peiyao Qiao, Ruilong Meng, Ruizhu Chen, Rui He, Le Du, Xinzheng Gao

pp. 865–874 · DOI: 10.5530/ijper.20256138 · 2025

Background: The objective of this study was to evaluate the effects of astaxanthin intake on the cardiovascular disease-related indicators. Materials and Methods: Fives databases, including PUBMED, CNKI, WEIPU, WAN FANG …

Diwakar Dhurandhar, Swanand Pathak, Tripti Chandrakar, Adarshlata Singh, Vaibhav Anjankar, Jagriti Agrawal

pp. 875–881 · DOI: 10.5530/ijper.20255720 · 2025

Background: Reflection or metacognition can be described as the process of contemplating one's own thinking. It facilitates the cultivation of profound learning and critical thinking skills. Reflective Practice Questionn…

Hayam Ali AlRasheed

pp. 882–888 · DOI: 10.5530/ijper.20250304 · 2025

Aim/Background: Case-Based Learning (CBL) has become a significant pedagogical approach in higher learning institutions, especially in disciplines that involve problem-solving and critical thinking. This research aims at…

Someshwar Mankar, Ashitosh Rohom, Suhas Siddheshwar

pp. 889–900 · DOI: 10.5530/ijper.20256726 · 2025

Background: The enhancement of drug solubility and bioavailability for orally administered medications remains a significant challenge in pharmaceutical formulations. This study focused on Azelnidipine, a poorly water-so…

Ranjit Kumar Harwansh, Mohammad Akhlaquer Rahman, Rohitas Deshmukh

pp. 901–912 · DOI: 10.5530/ijper.20256890 · 2025

Background: Generating Reactive Oxygen Species (ROS) at high altitudes causes several disorders, including skin aging. Genistein (GN) is a potent herbal bioactive compound found in many herbs like Soy GN has been reporte…

Ganesh Kumar, Meenakshi Bhatt, Archana Dhyani

pp. 913–922 · DOI: 10.5530/ijper.20255095 · 2025

Aim: The present work was aimed to formulate and optimize fast dissolving thin strips of Desvenlafaxine Hydrochloride using QbD. Materials and Methods: The solvent casting method was used to formulate fast dissolving thi…

Sunil Galatage, Arehalli Manjappa, Gajanan Paratkar, Amir Shaikh, Swapnil Harale, Rushikesh Katkar, Sujit Desai, Rahul Kadam, Gourisankar Kandukuri, Shyamsundar Pottabathula, Vishwajeet Swami

pp. 923–935 · DOI: 10.5530/ijper.20250457 · 2025

Background: Acne vulgaris is a disorder related to the skin (pilosebaceous), which is mainly caused by the formation of seborrhea, comedones, etc. It mainly affects the face, back, head and oil glands. In spite of the po…

Abhiram Kumar, Priyanka Maurya, Kumar Pranav Narayan

pp. 936–948 · DOI: 10.5530/ijper.20250924 · 2025

Aim: This study aims to enhance Glimepiride's (GMP) solubility and transdermal permeability by developing a matrix-type transdermal patch to improve systemic bioavailability, circumvent first- pass metabolism and decreas…

Sujit Karpe, Anil Chandewar, Nitin Kochar, Abhijit Shrirao

pp. 949–959 · DOI: 10.5530/ijper.20250544 · 2025

Background: Phytosomes are complex structures formed by the combination of natural phospholipids with phytoconstituents. The purpose could be to enhance the bioavailability of active compounds, such as flavonoids and pol…

Sung Hoon Lee

pp. 960–969 · DOI: 10.5530/ijper.20250933 · 2025

Aim: The study aimed to develop a once-daily sustained-release gastroretentive combination formulation of bepotastine besilate and montelukast sodium using multilayer tablet technology and gastro-retentive systems for th…

Swapnil Harale, Aviraj Kadam, Sunil Galatage, Arehalli Manjappa, Rushikesh Katkar, Sumit Shinde, Abhinandan A Alman, Prajyot Kumbhar, Kranti Bille, Rahul Kadam, Gourisankar Kandukuri

pp. 970–981 · DOI: 10.5530/ijper.20250630 · 2025

Background: Breast cancer is the leading and most frequent cancer among women worldwide, with rapidly growing new cases diagnosed, surpassing lung cancer. The current study aims to design, optimize and characterize Letro…

Gopal Prasad Agrawal, Adil Abalkhail, Osama Abdulaziz, Lina Eltaib, Muhammad Irfan Siddique, Abdullah Rzgallah Alzahrani, Abida Abida, Mohd Imran, Sherif Mohammed Shoeib, Faez Falah Alshehri, Zafer Saad Al Shehri, Ahmed Farag Elkirdasy, Benson Mathai Kochikuzhyil

pp. 982–994 · DOI: 10.5530/ijper.20251041 · 2025

Background: Skin infections caused by bacterial pathogens pose a significant health concern, necessitating the exploration of innovative therapeutic approaches. This study aimed to investigate the potential therapeutic e…

Fashli Syafiq Abd Razak, Liew Kai Bin, Shamima Abdul Rahman, Nurul Izzah Amirah Abdul Rashid, Nurul Akmar Abd Malek, Bontha Venkata Subrahmanya Lokesh, Wan Hamirul Bahrin Wan Kamal, Abd Almonem Dooalaanea, Mohamed Awang, Mohamad Faizal Safa at, Panairajan Vijayaraj Kumar

pp. 995–1006 · DOI: 10.5530/ijper.20256682 · 2025

Background: Naringenin, a polyphenolic phytochemical belonging to the flavanone class, exhibits notable anti-cancer, antioxidant, and anti-inflammatory properties. However, its therapeutic application is constrained by p…

Darshana Warekar, Nalini Kurup

pp. 1007–1015 · DOI: 10.5530/ijper.20250838 · 2025

Background: Gemcitabine hydrochloride (GEM) is a drug of choice in treatment of various malignancies, but has limited use for oral drug delivery because of its very short plasma half-life. Nanocochleates can be a promisi…

Xiaolong Mi, Lili Zhang Yunxia Ren, Tong Li, Jinfang Cheng

pp. 1016–1023 · DOI: 10.5530/ijper.20250957 · 2025

Background: Malvidin (MAL) is an anthocyanidin having therapeutic characteristics that provide several therapeutic advantages. Doxorubicin (DOX) is a valuable anti-tumor drug with a wider anticancer range; nevertheless, …

Vikas Malik, Avijit Mazumder, Saumya Das

pp. 1024–1031 · DOI: 10.5530/ijper.20253800 · 2025

Aim: This study focuses on finding the protective action of niosomal gel of Azadirachta indica (neem) leaf extract in ulcerative colitis. Materials and Methods: The pharmacological in vivo model conducted here was Dextra…

Xiaoning Fu, Ying Liu

pp. 1032–1041 · DOI: 10.5530/ijper.20251127 · 2025

Background and Objectives:Obstructive jaundice is characterized by excessive accumulation of bilirubin due to blockage of bile ducts. Chronic obstruction can result in various complications. Trigonelline, a plant alkaloi…

Qing Hua Wang, Ming Chao Ma, Ming Zhi Zhou, Xiao Yan Wang

pp. 1042–1052 · DOI: 10.5530/ijper.20251139 · 2025

Background: Allergic asthma is a global epidemic that significantly impacts the quality of life for both adults and children. Inhaled corticosteroids are regarded as the primary treatment for asthma, effectively alleviat…

Kuluvar Gouthamchandra, Sudeep Heggar Venkataramana, Bhoomika Ranganath, Amritharaj Amritharaj, Lingaraju Harakanahalli Basavegowda, Prasanna Kumara Thammatadhalli Parameshwarappa, Shyam Prasad Kodimule

pp. 1053–1058 · DOI: 10.5530/ijper.20250594 · 2025

Introduction: Camellia sinensis is the most frequent used plant source for making tea, which are categorized as green, white, yellow, oolong, black and dark, among them, purple tea is a new variant of green tea developed…