Volume 17, Issue 4

· pp. 752–996 · 30 articles

Volume: 17
Issue: 4
Published
Pages: 752–996
Articles: 30
Sections: 2
ISSN: Print - 0975-1483 | Online - 0975-1505
Journal: JYP

Review Article Original Artcile

In this issue

Review Article

Review
Dual Nephroprotective Strategy of Dapagliflozin and Telmisartan in the Management of Diabetic Kidney Disease: A Comprehensive Review
Yachita Rajwadwala, Priyanka Patil, Nidhi Chauhan, Umesh Upadhyay
pp. 752–762 · DOI: 10.5530/jyp.20250046 · Published
Diabetic Kidney Disease (DKD) is a leading cause of End-Stage Renal Disease (ESRD) worldwide, contributing substantially to morbidity and mortality among patients with Type 2 Diabetes Mellitus (T2DM). Its pathogenesis in…
Review
Pharmacological Approaches in Alcohol Use Disorder-Exploring Off-Label an Emerging Treatments in Clinical and Preclinical Evidence
Lakshman Ram, Mohammed Fayaz Sadiqbasha, Hariharan Murugadoss, Rishi Tushaar Vadlamannati, Hubert Igno Castus, Sarumathy Sundararajan
pp. 763–769 · DOI: 10.5530/jyp.20251770 · Published
Alcohol Use Disorder (AUD) presents a significant challenge, with limited efficacy and adherence to current FDA-approved treatments. This comprehensive review analyzes the spectrum of pharmacological management for AUD. …
Review
Artificial Intelligence in Hemovigilance: Advancing Blood Safety and Monitoring Systems
Ragesh Gurumoorthy, Karthik Thiyagarajan, Santhosh Kumar Ganesan
pp. 770–776 · DOI: 10.5530/jyp.20251751 · Published
Blood transfusion is one of the key practices in making sure that the safety of the patients remains intact; however, traditional systems are being faced with a substantial number of challenges, such as underreporting ut…
Review
Ferroptosis as a Therapeutic Target: Advances in Drug Development for Cancer and Neurodegenerative Diseases
Bhishmani Tarare, Sadhana Misar, Vinay Kumar, Mohnish Gokhale
pp. 790–796 · DOI: 10.5530/jyp.20250082 · Published
Background:Ferroptosis is an iron-dependent, regulated form of cell death characterized by lipid peroxidation and oxidative stress, distinct from apoptosis and necrosis. It has emerged as a key therapeutic target in canc…
Review
Aging and Immune Receptor Signaling: Molecular Mechanism Investigation to Pharmacological Intervention
Alindam Ghosh, Arpan Sen, Avik Dutta, Soumya Sunder Ghora, Saurav Guchhait, Susobhan Das, Faruk Alam, Mrinmoy Nag, Sindhuja Sengupta, Prithviraj Chakraborty
pp. 797–809 · DOI: 10.5530/jyp.20250069 · Published
Immunological receptor signaling maintains homeostasis and prevents infections. Significant immune system changes like immunosenescence decrease innate and adaptive immunity. This lowers resistance to cancer, autoimmune …
Review
Impact of Long-Term PPI Therapy on Vitamin C Levels: Emerging Concerns
Jenita Varshini Anthony Raj, Priyadharshini Ananthathandavan, Safreen Rumana Sella Babu, Harinipriya Arunagiri
pp. 810–815 · DOI: 10.5530/jyp.20250007 · Published
PPIs are the most popular medications used in treatment of gastric diseases based on acids, and they turn out to be the strongest agents to suppress the acids. But extended use has been associated with hypochlorhydria an…
Review
Advancement and Future Window of Emulgel for Intensifying Transdermal Delivery in the Treatment of Skin Diseases
Piyali Khamkat, Soumen Singh, Bramhajit Chatterjee, Sangita Banerjee, Siddheswar Maiti, Sayandip Mandal, Bikram Chowdhury, Md Mehedi Hasan
pp. 816–823 · DOI: 10.5530/jyp.20250008 · Published
Emulgel is a blend of gel and emulsion that improves drug penetration across the epidermal barrier and facilitates efficient skin diffusion, particularly for drugs that are poorly soluble in water. It is a potent, thermo…
Review
Metabolic Syndrome and Binge Eating in Children: A Comprehensive Review
Paras Monga, Rina Das, Bimal Kumar Agrawal, Dinesh Kumar Mehta
pp. 824–832 · DOI: 10.5530/jyp.20250040 · Published
Children who binge eating are at a higher risk of becoming overweight. The Metabolic Syndrome (MetS) significantly predicts Type 2 diabetes and coronary heart disease in obese children and adolescents. The accumulation o…
Review
Eco-Friendly AQbD-Driven HPLC: A Sustainable Approach to Method Development and Validation Using Green Chemistry
Gummalla Vijayamma, S. Nirmala
pp. 833–840 · DOI: 10.5530/jyp.20250087 · Published
The integration of Analytical Quality by Design (AQbD) with Green Analytical Chemistry (GAC) represents a transformative approach in High-Performance Liquid Chromatography (HPLC) method development and validation. This r…

Original Artcile

Article
Advances in Green Analytical Techniques for Impurity Profiling in Pharmaceuticals
Anamika Dey, Nagarajan Janaki Sankarachari Krishnan, Shenthilnathan Sivakumar, Sarvesh Ravichandran, Mullaiadhavan Bharathi, Pavalan Krishnan
pp. 777–783 · DOI: 10.5530/jyp.20250075 · Published
This study provides an overview of the green analytical methods in pharmaceutical impurity profiling with focus on regulatory compliance, effectiveness, and environmental impact. We address recent trends in spectroscopic…
Article
Pharma 4.0: Enhancing Process Robustness in Pharmaceutical Manufacturing through Industry 4.0 Integration
Rajesh Balam, Priyanka Mahesh, Kinjal Gandhi, Swathi Ganesha Poojary, Ajith Chandran, Anoop Narayanan Vadakkepushpakath
pp. 784–789 · DOI: 10.5530/jyp.20250104 · Published
The pharmaceutical industry is currently welcoming a digital revolution known as Pharma 4.0, which builds upon the principles of Industry 4.0 to improve product quality, operational efficiency, and compliance. This trans…
Article
Formulation and Evaluation of Truptighna Mahakashaya Syrup: An Ayurvedic Intervention for Pediatric Appetizer
Ashwini Kumar Patil, Brugupati Pandey, Bharat Patil, Aboli Patil, Rupali Bawa
pp. 841–846 · DOI: 10.5530/jyp.20250015 · Published
Background:Charak Samhita mentions Truptighna Mahakashaya as a group of herbs effective in treating Kaphaja disorders, commonly seen in children with loss of appetite and Kapha dominance. However, traditional formulation…
Article
Strategic Alignment of Saudi Pharmacy Education and the Pharmaceutical Industry: A Document-Based SWOT and Matrix Evaluation under Vision 2030
Farhan Alshammari
pp. 847–854 · DOI: 10.5530/jyp.20250009 · Published
Objectives:This study aimed to conduct a comprehensive strategic evaluation of Saudi Arabia’s pharmaceutical industry in relation to pharmacy education, with a focus on industrial localization, regulatory capacity, and c…
Article
Seasonal Assessment of Microbial Contamination and Disinfectant Efficacy in Cleanroom using MALDI-TOF MS in a NABL-Accredited Pharmaceutical Testing Laboratory
Harsha Prashant Kavale, Vijay Jagdish Upadhye
pp. 855–863 · DOI: 10.5530/jyp.20250081 · Published
Background:Microbial bioload control in clean rooms is critical for ensuring pharmaceutical product quality. Regular monitoring and effective disinfection practices are essential to minimize contamination risks. This stu…
Article
Quality-by-Design Optimization of Biotin-Coated Tetronic® 1107 Polymersomes for Carboplatin Delivery in Non-Small Cell Lung Cancer
Nithyananth Muniswamy, Sankar Veintramuthu, Malathi Sellappan
pp. 864–876 · DOI: 10.5530/jyp.20250096 · Published
Background:For driver-negative Non-Small Cell Lung Cancer (NSCLC), platinum-based chemotherapy remains standard; however, carboplatin efficacy is limited by poor tumour delivery and dose-limiting toxicity. In this study,…
Article
Formulation, Central Composite Design Optimization and in vitro Evaluation of Folic Acid Conjugated Palbociclib Loaded Polymeric Nanoparticles
Nurjamal Hoque, Ananta Choudhury, Deepraj Datta
pp. 877–886 · DOI: 10.5530/jyp.20250155 · Published
Background:The efficacy of the anticancer agent palbociclib can be limited by its conventional release profile. Developing nano-formulations presents a viable approach to modulate its delivery for improved therapeutic ou…
Article
Design, Biological Evaluation, and Zebrafish Embryo Toxicity of a Novel Pyrazoline Derivative
Ravali Ravi, Sowmiya Raju, Siena Jasmine Chinnappan, Abhimanyu K. Singh, Rakesh Sarma, Joseva Sankar
pp. 887–901 · DOI: 10.5530/jyp.20250134 · Published
Background:Pyrazoline derivatives have significant medicinal use for their diverse pharmacological activities. Zebrafish embryos are mostly used in toxicity studies due to its transparency, rapid development and genetic …
Article
A Novel Sustainable UV Spectrophotometric Approach for the Quantification of Amisulpride in Bulk and Nanoformulations
Kishori Prasanna Sutar, Utkarsh Shashtri, Vinayak Patil, Atharv Milind Lad, Nagaprajwal Anantha Araga, Gangayya Wakkundmath
pp. 902–908 · DOI: 10.5530/jyp.20250249 · Published
Background:Schizophrenia is a persistent neuropsychiatric condition that requires precise drug delivery to the brain for effective treatment. Amisulpride, a second-generation antipsychotic, has low oral bioavailability a…
Article
Synergistic Antioxidant and Anti-Apoptotic Effects of Captopril and Spironolactone in Streptozotocin-Induced Damage to Human Granulosa-Like KGN Cells
Chandana Ganesha, Mohammad Ali, Bharathi Doddla Raghunathanaidu
pp. 909–913 · DOI: 10.5530/jyp.20250041 · Published
Background:Diabetes mellitus causes ovarian granulosa cells to undergo oxidative stress, inflammation, and apoptosis, all of which have a negative impact on female reproductive health. Although there are currently few tr…
Article
Effect of Caralluma fimbriata Hydroalcoholic Extraction on Olanzapine-Induced Hyperphagia and Metabolic Changes in Rats
Dighe Santosh Bhausaheb, Jadhav Shweta Shantaram, Bhawar Sanjay Balasaheb, Ghogare Rajshree Dadasaheb, Patole Varsha Aniket, Patil Samrudhi Santosh
pp. 914–921 · DOI: 10.5530/jyp.20250150 · Published
Background:Olanzapine an atypical antipsychotic, is known to cause metabolic side effects such as weight gain, hyperlipidemia and oxidative stress, contributing to the development of metabolic syndrome. Caralluma fimbria…
Article
Impact of Cytochrome P450 and P-gp-Mediated Drug Interactions in Patient Prescriptions at a Tertiary Care Hospital: A Cross-Sectional Follow-Up Study
Atla Sai Keshava Reddy, Ambati Sandeep Reddy, Kiranmai Venkatagiri, Sahana Shivanand, Bhavya Sai Sakhamuri, Mitta Putta Pooja, Venkata Sai Krishna Setlem
pp. 922–927 · DOI: 10.5530/jyp.20250010 · Published
Background:Drug interactions, especially those mediated by CYP450 enzymes and P-glycoprotein (P-GP), contribute significantly to medication errors and are often overlooked in clinical practice. Identifying and managing t…
Article
Assessment of Pain by Brief Pain Inventory (BPI) and Analgesics Utilization Pattern in Cancer Patients Receiving Palliative Care: A Prospective Observational Study
Pritish Rane, Aakansha Chaturvedi, Kanchan Shelke, Payal Holmukhe, Rohini Chavan, Anamika Bhoyar, Sonali Bhasme
pp. 928–933 · DOI: 10.5530/jyp.20250013 · Published
Background:Pain is a prevalent worry in advanced cancer, significantly impairing patients’ quality of life, functional ability, and emotional well-being during palliative care. Effective pain management, guided by the Wo…
Article
A Cross-Sectional Analysis of Health Status, Economic Burden, and Lifestyle Factors among Patients with Type 2 Diabetes at a Tertiary Care Hospital
Irshad Pasha, Baharul Islam Haidary, Gautham Krishna, Srikantesh Seegekuppe Puttaraju, Robin George, Hafis Ambalapotta, Bettur Jayappa Mahendra Kumar, Rajesh Venkataraman
pp. 934–941 · DOI: 10.5530/jyp.20250064 · Published
Background:Type 2 Diabetes Mellitus is one of the most prevalent non communicable chronic disease globally. Early detection and modification of lifestyle including diet and physical activity, are crucial to prevent the p…
Article
Impact of Coronary Artery Diseases on the Quality of Life and Psychological Well-Being
Mayank Jain, Divya Tandon, Vansh Vohra, Arti Saini, Inderjeet Verma
pp. 942–946 · DOI: 10.5530/jyp.20250084 · Published
Background:Globally, the major source of morbidity and mortality is Coronary Artery Disease (CAD). In addition to its direct physiological effects, CAD has a significant effect on people's psychological well-being and Qu…
Article
A Cohort Study of SGLT-2 Gliflozins and its Effect on Glycaemic Index in CHF Patients With and Without Diabetes
Robin George, Nischitha Jagadeesh, Irshad Pasha, B J Mahendra Kumar, Yathish B E
pp. 953–959 · DOI: 10.5530/jyp.20250148 · Published
Background:Although there are many treatment options available, SGLT-2 inhibitors are emerging as effective agents in the treatment of congestive heart failure (CHF) patients with and without diabetes. This study aims to…
Article
Impact of Clinical Pharmacist-Led Discharge Counseling on Health Outcomes and Quality of Life in Chronic Disease Patients
Rajesh Hadia, Dhaval Joshi, Aniket Rana, Merlyn Selvyaraj, Preet Desai, Bhavin Vyas
pp. 960–969 · DOI: 10.5530/jyp.20250091 · Published
Objectives:Patients with chronic disorders like Ischemic Heart Disease (IHD), Acute Coronary Syndrome (ACS), Stroke and associated coexisting disorders such as Chronic Kidney Disease (CKD), Hypertension (HTN), Diabetes M…
Article
Pharmacoeconomic Analysis of Chemotherapy Regimens in Breast Cancer Management; An Oncology Pharmacoeconomical Approach
Baharul Islam Haidary, Rajesh Venkataraman, Irshad Pasha
pp. 970–979 · DOI: 10.5530/jyp.20250162 · Published
Background:Pharmacoeconomic evaluation of breast cancer drugs is essential due to their high treatment costs. Comparing therapeutic options and associated expenses supports better decision-making and helps optimize resou…
Article
Prevalence of Wasting Diseases and Oral Hygiene Practices among Construction Workers: A Cross-Sectional Study
Sivashankari Boobalan, Sri Sakthi Doraikannan, Meignana Arumugham I, Logesh Sidhu
pp. 980–985 · DOI: 10.5530/jyp.20251519 · Published
Background:Oral health holds equal significance to general health and is an invaluable asset for every individual. The evidence of occupation of people and oral health hazards related to construction sites instills a har…
Article
Social Determinants of Exclusive Breast Feeding Among Family Farmers in Central Myanmar
Winn Lwin Htoo, Theingi Maung Maung, Prabal Bhargava, Hnin Pwint Phyu, Sherly Deborah George, Myo Hlaing Win, Aye Thiri Mon, Suu Mon Phyo, Myat Noe Wai, Zin Min Naing, Sai Htet, Khaing Lay Mon
pp. 986–990 · DOI: 10.5530/jyp.20250056 · Published
Background:Undernutrition is a public health problem in many developing countries. Providing better care and nutritional improvement are still challenges in rural areas of Myanmar. Agriculture is the main sector in the c…
Article
A Cross-Sectional Study to Assess the Effectiveness of Ethereum and Nexus Blockchain Platforms in Preventing Counterfeit Drugs
Sriram Shanmugam, Poonguzhali Viswanathan, Sahana Fathima Amudha, Dhivya Ramachandran, Thamarai Selvan Mohan, Shakthivel Chinnasamy Dhandapani, Gokulavasa Nagarajan, Narayanasamy Krishnasamy, Kalpana Ramachandran6
pp. 991–996 · DOI: 10.5530/jyp.20250115 · Published
The rise of counterfeit medicines poses serious health risks to the public and threatens the credibility of pharmaceutical companies. Blockchain technology is gaining attention for its potential to enhance the security a…