Volume 54, Issue 2

Original Article(continued)

1. Article

   Anti-urolithiatic Activities of Macrotyloma uniflorum Mediated through Multiple Pathway

   Vaibhavkumar Baldevbhai Patel, Niyati Acharya

   pp. 403–415 · DOI: 10.5530/ijper.54.2.46 · 2020

   Background: Macrotyloma uniflorum Linn. (Fabaceae) seeds are widely used for their diuretic and urolithiatic effects in India. The present study investigated the effect of n-butanol fraction of M. uniflorum (nBFMU) on ki…

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2. Article

   Apoptosis of HeLa Cells via Caspase-3 Expression Induced by Chitosan-Based Nanoparticles of Annona squamosa Leaf Extract: In vitro Study

   Amaq Fadholly, Arif Nur Muhammad Ansori, Annise Proboningrat, Alexander Patera Nugraha, Regina Purnama Dewi Iskandar, Fedik Abdul Rantam, Sri Agus Sudjarwo

   pp. 416–421 · DOI: 10.5530/ijper.54.2.47 · 2020

   Background: Annona squamosa is reported has a significant cytotoxic activity in some cancer cells. Objectives: Thus, this study aim to investigate Annona squamosa leaf extract induced by chitosan nanoparticles (nano-ASLE…

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3. Article

   Cerebral Cortex and Hippocampal Protection Mediated by Callistemon viminalis in Aluminium Chloride Induced Alzheimer’s Disease

   Mandeep Singh, Yash Prashar

   pp. 422–431 · DOI: 10.5530/ijper.54.2.48 · 2020

   Aim: The study was carried out to evaluate the neuroprotective effect of methanol extract of Callistemon viminalis in aluminium chloride induced dementia of alzheimer’s type in mice. Methods: Swiss albino mice of either …

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4. Article

   N-(2-(1H-benzo[d]imidazol-2-yl)Phenyl)-2- (Substituted-styryl)Aniline as Anti-proliferative Agents: Rejuvenating the Importance of Low Molecular Weight Ligands in Oncotherapeutics

   Santosh Subhash Chhajed, Pramodkumar P Gupta, Sanjay Kshirsagar, Sakshi Tomar, Debarshi Kar Mahapatra, Raji Sundararajan

   pp. 432–439 · DOI: 10.5530/ijper.54.2.49 · 2020

   Background: The rationale behind the study involved that in individuality benzimidazolebased molecules demonstrates significant anti-proliferative activity; chalcone molecules like xanthohumol are known to express notewo…

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5. Article

   LC-MS/MS Determination and Pharmacokinetics Study of Apremilast after Oral Administration in Rabbits

   Tammisetty Mohan Rao, Challa Balasekhara Reddy, Puttagunta Srinivasa Babu

   pp. 440–447 · DOI: 10.5530/ijper.54.2.50 · 2020

   Objectives: A selective and reproducible method has been optimised for evaluation of Apremilast in rabbit biological matrices by UPLC-ESI-MS/MS. Methods: The analytical technique was implemented to quantify the apremilas…

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6. Article

   Quantitative Analysis of Pantoprazole Sodium Sesquihydrate in Bulk and Solid Dosage Form via UV-Spectrophotometric Method

   Asma Rafiq, Somia Gul, Arzoo Ajaz, Sakina Fatima, Agha Zeeshan Mirza

   pp. 448–455 · DOI: 10.5530/ijper.54.2.51 · 2020

   Pantoprazole sodium sesquihydrate, is a proton pump inhibitor, was analyzed by using UV spectrophotometry. The quantification of pantoprazole sodium sesquihydrate in distilled water was performed in the wavelength range …

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7. Article

   Robust Analytical Method for Iron Estimation by Experimental Design Approach

   Mahendra Ramdas Mahajan, Dipak Dhanraj Patil

   pp. 456–464 · DOI: 10.5530/ijper.54.2.52 · 2020

   Aim: To perform Iron estimation by UV-Visible spectroscopy using an Experimental design approach. Objectives: The robust analytical method was developed for the estimation of iron (III) using 1, 10-phenanthroline reagent…

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8. Article

   HPLC Method for Determination of the Chemical Stability of Antimicrobial Peptide α-Defensin 2

   Vania Maslarska, Meri Amerikova, Ivanka Pencheva, Stanislav Bozhanov

   pp. 465–470 · DOI: 10.5530/ijper.54.2.53 · 2020

   Aim: The aim of this research study was to develop a simple, rapid, precise, accurate and economical RP-HPLC method, with a simple mobile phase for the identification and determination of the antimicrobial peptide α-defe…

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9. Article

   Synthesis, in-silico Designing, SAR and Microbiological Evaluation of Novel Amide Derivatives of 1-(4-Nitrophenyl)-2-(3-methylbenzo[b] thiophen-6-yl)-1H-benzo[d]imidazole-5-carboxylic Acid

   Tanuj Hooda, Sunil Sharma, Naveen Goyal

   pp. 471–483 · DOI: 10.5530/ijper.54.2.54 · 2020

   Background: Due to this increasing predicament of antibiotic confrontation, the lot of distinct antibiotics available is dwindling and there are only smatterings of new antibiotics in the drug development channel. Theref…

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10. Article

    Antioxidants with Multivitamin and Mineral Supplementation Attenuates Chemotherapy or Radiotherapy-induced Oxidative Stress in Cancer Patients

    Ravikant Yashwantrao Patil, Harinath Nivrutti More

    pp. 484–490 · DOI: 10.5530/ijper.54.2.55 · 2020

    Aim: The present study was planned to evaluate the combined effects of antioxidant multivitamin and minerals (AMM) in reducing cancer and cancer therapy-induced oxidative stress. In addition cell viability of human malig…

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