Volume 56, Issue 3

Shery Jacob, Anroop B Nair, Mohamed A Morsy

pp. 600–607 · DOI: 10.5530/ijper.56.3.108 · 2022

Selecting the most appropriate first-in-human and pharmacologically active dose for any new drugs or biologicals is a crucial step before starting a clinical trial investigation in adult healthy human subjects. Extrapola…

Meenakshi Bharkatiya, Komal Sharma

pp. 608–617 · DOI: 10.5530/ijper.56.3.109 · 2022

Amphiphilic copolymers which can self-organize into distinct nano vesicles comprising of hydrophilic core and a hydrophobic bilayer membrane with innumerable morphologies have wide applications ranging from cell mimics t…

Shanthi Lysetty, Siva Kumar Kannan, Anup Naha, Usha Yogendra Nayak, Virendra Ligade

pp. 618–627 · DOI: 10.5530/ijper.56.3.110 · 2022

Skill industries, such as manufacturing and services, are growing at a rapid rate. It is estimated that there is a huge demand for skilled employees in the future. But India’s skilled workforce is very low. The country i…

Aman Shrivastava, Jeetendra K Gupta, Manoj K Goyal

pp. 628–635 · DOI: 10.5530/ijper.56.3.111 · 2022

Epilepsy is a chronic neurological condition in which several neurotransmitters act like neuromodulators. The symptoms of epilepsy are caused by abnormal electrical discharges in a group of neurons in the hippocampus reg…

Afzal Haq Asif, Anroop Nair, Bandar Aldhubiab, Sreeharsha Nagaraja, Girish Meravanige, Syed Mohammed Basheeruddin Asdaq, Md. Khalid Anwer, Arshia Shariff, Syed Dawood Noor

pp. 636–645 · DOI: 10.5530/ijper.56.3.112 · 2022

The characteristic feature of Interstitial cystitis (IC) or bladder pain syndrome is augmented, pressure, or inconvenience in the suprapubic or bladder region. The causative factors for IC are not completely understood h…

Shivkant Sharma, Manish Devgun, Rakesh Narang, Sukhbir Lal, Avtar Chand Rana

pp. 646–666 · DOI: 10.5530/ijper.56.3.113 · 2022

Thiazole or 1,3-thiazole is a distinct heterocyclic compound which incorporates sulphur and nitrogen atoms. It is a vital framework present in numerous pharmacologically active compounds, be it of natural origin or of sy…

Pathiyil Ravi Shankar, Rano Mal Piryani, Subish Palaian

pp. 667–672 · DOI: 10.5530/ijper.56.3.114 · 2022

Interactive teaching/learning is becoming more common in medical schools. Basic science teaching is often considered dry, uninteresting, and considered by students to be not ‘directly’ relevant to their future career as …

Andrea Xin Wei Yap, Hui Meng Er, Sook Han Ng, Vishna Devi Nadarajah

pp. 673–680 · DOI: 10.5530/ijper.56.3.115 · 2022

Introduction: Service learning is commonly incorporated into the curricula of health professions programmes to provide a platform for students to acquire competencies outside the classroom. The objectives of this study w…

Sunil Kumar, Abhishek Tiwari, Naveen Goyal

pp. 681–688 · DOI: 10.5530/ijper.56.3.116 · 2022

Aim/Background: The objective behind this study was to develop a Microspheres of Lafuditine using central composite design for gastroretentive drug delivery. Materials and Methods: Gastroretentive Microspheres were prepa…

Nandhakumar Sathyamoorthy, Vankayala Devendiran Sundar, Vijayalakshmi Rajendran, Navyashri Sirikonda, Harikrishnan Narayanaswamy

pp. 689–696 · DOI: 10.5530/ijper.56.3.117 · 2022

Background: Zidovudine (Azidothymidine, AZT) is widely used in the treatment of Acquired Immuno Deficiency Syndrome (AIDS) and related conditions, either alone or in combination with other antiviral agents to combat HIV.…

Sandeep Rathor, DC Bhatt

pp. 697–704 · DOI: 10.5530/ijper.56.3.118 · 2022

Introduction: Formulation of phospholipid complex is an ideal approach to improve the solubility of poorly soluble drugs. Objectives: This study has been aimed to prepare a novel glibenclamide-phospholipid complex by usi…

Shincy Mariya Francis, Elizabeth N Xavier

pp. 706–715 · DOI: 10.5530/ijper.56.3.119 · 2022

Introduction: Lawsone is a phyto-constituent obtained from the leaves of the Lawsonia inermis. It has antibacterial, antifungal, antiviral, wound healing, antiparasitic, tuberculostatic, anti-fertility, analgesic, anti-i…

Kavita Attri, Manvi Singh, Vijay Bhalla

pp. 716–722 · DOI: 10.5530/ijper.56.3.120 · 2022

Aim: The present study aims at exploring the development of xylometazoline hydrochloride loaded chitosan nanoparticles (XYL-NP) cross linked with calcium chloride for the treatment of nasal congestion. Materials and Meth…

Yosif Almoshari, Mohammad Intakhab Alam, Mohammed Ali Bakkari, Ahmad Salawi, Meshal Alshamrani, Fahad Y Sabei, Awaji Y Safhi, Jawaher Abdullah Alamoudi, Ibrahim M Ibrahim

pp. 723–731 · DOI: 10.5530/ijper.56.3.121 · 2022

Background: Colorectal cancer (CRC) has grown to be the world’s fourth-biggest cause of cancer-related mortality. It is critical to identify more effective treatment options for it. Objectives: Doxorubicin a potent antin…

Prabhat Kumar, Purnima Jain, Anjana Sarkar

pp. 732–738 · DOI: 10.5530/ijper.56.3.122 · 2022

A cost-effective mass production of pristine graphene nanosheet is still an important challenge to harness its maximum potential in medical sciences. Here, we have used a binary solvent mixture of low dielectric constant…

H Turan Akkoyun, Sevinç Aydın, Mahire Bayramoglu Akkoyun, Aydın Şükrü Bengü, Suat Ekin, Sinem Aslan Erdem

pp. 740–747 · DOI: 10.5530/ijper.56.3.123 · 2022

Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte and serum fatty acid profile which is exposed to potassium bromate (KBrO3) were investigated. Materials and Methods: In this study, …

Murat Cabalar, Serdar Altınay, Funda Yildirim, Duygu Sultan Celik, Suat Hayri Kucuk, Cihan Isler, Nilgun Isiksacan, Arsida Bajrami, Ahmet Gulcubuk

pp. 748–755 · DOI: 10.5530/ijper.56.3.124 · 2022

Background: Some researches reveal that pharmacologic and phytotherapeutic agents have benefits on neurological disorders associated with the effects of reactive oxygen species. Aim: The purpose of this research was to e…

Akanksha Dubey, Jayanthi Sivaraman

pp. 756–764 · DOI: 10.5530/ijper.56.3.125 · 2022

Introduction: Seaweeds are the reservoir of bioactive constituents such as proteins, polysaccharides, alkaloids, steroids and terpenoids that possess antioxidant, antiinflammatory and anti-cancerous properties. Dictyota …

Mazin Aboobaida Abdalla Abdelaziz, Vijayan N Azger Dusthackeer, Ramalingam Peraman

pp. 765–771 · DOI: 10.5530/ijper.56.3.126 · 2022

Background and Objectives:Considering the unexplored therapeutic potential of a plant, Grewia obtusa (G. obtusa), and the study evaluated the biological potential of fruit extract for antitubercular and anticancer activi…

Subramani Parasuraman, Yap Zi Qi, Loo Wei Jie

pp. 772–779 · DOI: 10.5530/ijper.56.3.127 · 2022

Objectives: The present study is planned to investigate the hepato- and nephroprotective effects of ethanolic extract of seeds of Macrotyloma uniflorum (EEMU) on paracetamol (PCM)-induced hepato- and nephrotoxicity in Sp…