Volume 2, Issue 4

Vipra Kundoor, Mueen Ahmed KK

pp. 339–341 · DOI: 10.4103/0975-1483.71618

Drug discovery nowadays is a highly innovative process by which new drugs are discovered and/or designed. It is expected that in the year 2010, at least 50% of all new approved drugs will come from the biopharmaceutical …

Jain S, Srinath MS, Narendra C, Reddy SN, Sindhu A

pp. 342–349 · DOI: 10.4103/0975-1483.71619

The objective of this study was to evaluate the effect of formulation variables on the release properties, floating lag time, and hardness, when developing floating tablets of Ranitidine hydrochloride, by the statistical…

Vedha Hari BN, Brahma Reddy A, Samyuktha Rani B

pp. 350–355 · DOI: 10.4103/0975-1483.71622

A multiple-unit floating drug delivery system based on gas formation technique was developed, in order to prolong the gastric residence time and to increase the overall bioavailability of the dosage form. The floating be…

Prabhu P, Nitish Kumar R, Koland M, Harish NM, Vijayanarayan K, Dhondge G, Charyulu RN

pp. 356–361 · DOI: 10.4103/0975-1483.71623

The objective of the present investigation was to design a vesicular formulation of brimonidine tartrate and evaluate its ability to reduce the dosing frequency and improve the therapeutic efficacy of the drug. Nanovesic…

Coutinho HDM, Matias EFF, Santos KKA, Tintino SR, Souza CES, Guedes GMM, Santos FAD, Costa JGM, Falcão-Silva VS, Siqueira-Júnior JP

pp. 362–364 · DOI: 10.4103/0975-1483.71625

This is the first on the modulation of norfloxacin antibiotic activity by the volatile compounds of an essential oil. We report the chemical composition and antibiotic modifying activity of the essential oil extracted fr…

Kumar D, Kumar S, Singh J, Narender N, Rashmi R, Vashistha BD, Singh N

pp. 365–368 · DOI: 10.4103/0975-1483.71627

The aqueous fruit extract of Cucumis sativus L. was screened for free radical scavenging and analgesic activities. The extract was subjected to in vitro antioxidant studies at 250 and 500 μg/ml and analgesic study at the…

Roy SP, Niranjan CM, Jyothi TM, Shankrayya MM, Vishawanath KM, Prabhu K, Gouda VA, Setty RS

pp. 369–373 · DOI: 10.4103/0975-1483.71629

The antiulcer and in vitro anti-inflammatory activities of the aerial parts of Enicostemma littorale against aspirin, ethanol, and pyloric ligation-induced ulcers in rats and bovine serum albumin denaturation were studie…

Lalchhandama K

pp. 374–378 · DOI: 10.4103/0975-1483.71630

Albendazole, a member of benzimidazole group of compounds, has been shown to have a broad spectrum activity against all classes of helminth parasites. Although it has also been experimentally proven to be effective again…

Srirangam P, Vidya Sagar J

pp. 379–383 · DOI: 10.4103/0975-1483.71632

The everted gut sac method was used to assess the role of the P-glycoprotein (P-gp) on the intestinal secretion of glibenclamide, a prototype of drug used to treat diabetic mellitus. The study included the evaluation of …

Jimam NS, Wannang NN, Omale S, Gotom B

pp. 384–387 · DOI: 10.4103/0975-1483.71633

The hypoglycemic effects of the fruit extract of C. metuliferus was investigated in normoglycemic and alloxaninduced hyperglycemic rats. The results showed that there was an insignificant (P > 0.05) decrease in the blood…

Ganguly S, Mishra R

pp. 388–393 · DOI: 10.4103/0975-1483.71635

A three-dimensional quantitative structure-activity relationship (3D QSAR) of 44 structurally and functionally diverse series of 1- (Naphthylalkylimidazoles) as antiepileptic agents was studied using the Comparative mole…

Alang G, Kaur G, Kaur R, Singh A, Tiwari R

pp. 394–398 · DOI: 10.4103/0975-1483.71636

In the present study, five new derivatives (GG4 to GG8) of benzothiazoles were synthesized and evaluated against Staphylococcus aureus (MTCC 737), Pseudomonas aeruginosa (MTCC 424), Escherichia coli (MTCC 1687), and yeas…

Shabani F, Ghammamy S, Jahazi A, Siavoshifar F

pp. 399–402 · DOI: 10.4103/0975-1483.71638

Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N4[(E)-1-(2-hydroxyphenyl) methylidene…

Anand K, Saini SK, Singh BK, Veermaram C

pp. 403–409 · DOI: 10.4103/0975-1483.71637

In the medical device field, there are a number of players, having quite different responsibilities and levels of understanding of the processes, but all with one common interest, that of ensuring the availability of sou…

Thiruvengada Rajan VS, Mohamed Saleem TS, Ramkanth S, Alagusundaram M, Ganaprakash K, Madhusudhana Chetty 3

pp. 410–413 · DOI: 10.4103/0975-1483.71634

An isocratic reversed phase high-performance liquid chromatographic method with ultraviolet detection at 220 nm has been developed for the quantification of itopride hydrochloride in tablet dosage form. The quantificatio…

Sivakumar R, Nallasivan PK, Saranya KC, Sam Solomon WD, Akelesh T, Venkatnarayanan R

pp. 414–416 · DOI: 10.4103/0975-1483.71631

Two simple, sensitive, accurate, rapid, and economical spectrophotometric methods have been developed for the estimation of diacerein in Pharmaceutical dosage forms. Method A is based on the reaction of diacerein with Fo…

Deepali G, Elvis M

pp. 417–419 · DOI: 10.4103/0975-1483.71628

A rapid, simple, accurate, and economical spectrophotometric method has been developed and validated for the assay of the anti-retroviral agent lamivudine in active pharmaceutical ingredients (API) and in its tablet form…

Sharma S, Rajpurohit H, Sonwal C, Bhandari A, Choudhary VR, Jain T

pp. 420–423 · DOI: 10.4103/0975-1483.71626

A new, simple, fast and reliable zero order spectrophotometric method has been developed for determination of Escitalopram Oxalate in bulk and tablet dosage forms. The quantitative determination of drug was carried out u…

Swamy VKM, Setty RS, Shankaraiah MM, Jyothi TM, Rajendra SV

pp. 424–427 · DOI: 10.4103/0975-1483.71624

Drug–drug interaction between esomeprazole at therapeutic and higher doses and sulfonylureas was studied. Sulfonylureas (tolbutamide 40 mg/kg and glibenclamide 40 μg/kg) were administered and the time to onset of hypogly…

Mahajan R, Gupta K

pp. 428–429 · DOI: 10.4103/0975-1483.71621

Monitoring of adverse drug reactions of a drug is a continuous process and runs through-out the life of a drug. Many rare adverse effects of a drug are documented after years of use; when a single case (signal generation…