Table of Contents

Original Article

1. Article

   Exploring the Topical Gel of Thespesia populnea leaf Extract for in vivo Wound Healing Efficacy

   Afzal H. Asif, Salim M. Mulla, Arshia Shariff, Nagaraja Sreeharsha, Girish Meravanige, Predeepkumar N. Shiroorkar, Syed Mohammed Basheeruddin Asdaq, Md. Khalid Anwer, Teeka S. Roopashree, Ranjith K. Karnati

   pp. 519–523 · DOI: 10.4103/pm.pm_25_22 · 2022

   Aim: Thespesia populnea is a plant known for its polyphenol and flavonoid content, which plays a crucial role in wound healing activity. Traditionally, extracts of various parts of T. populnea plant have been used to tre…

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2. Article

   Escin Attenuates Inflammation and Oxidative Stress and Preserves Renal Function in Hyperoxaluric Rats

   Qingfei Yu, Peng Qu, Vidya Devanathadesikan Seshadri, Xiaogang Wang

   pp. 524–531 · DOI: 10.4103/pm.pm_251_21 · 2022

   Background and Objectives: Oxalate is a toxic metabolite, which is predominantly excreted through the kidneys. Hyperoxaluria is a clinical condition characterized by the occurrence of excessive amounts of oxalate in the …

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3. Article

   Anticancer Potential of Piper retrofractum on Breast Cancer MCF‑7 Cells Via Induction of Cell Death and Reduction of Cell Migration

   Benjaporn Buranrat

   pp. 532–539 · DOI: 10.4103/pm.pm_455_21 · 2022

   Background: Piper retrofractum (PR) is traditional medicine in the South‑East country. Objectives: This study examined the PR effects on anticancer and anti‑migratory activity in human breast cancer cells. Materials and …

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4. Article

   Esculetin Ameliorates Cognitive Impairments in D‑Galactose‑Induced Alzheimer’s Disease Rats by Inhibiting Inflammation and Oxidative Stress

   Xinmin Yao, Miao Yu, Yanyan Zhou, Huibo Guan

   pp. 540–547 · DOI: 10.4103/pm.pm_524_21 · 2022

   Background: Alzheimer disease (AD) is a common form of dementia and is described by memory loss and behavioral disorder. The prevalence of AD is increasing rapidly each year worldwide. Objectives: In this study, we aimed…

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5. Article

   GC–MS Metabolomics and Network Pharmacology‑Based Investigation of Molecular Mechanism of Identified Metabolites from Tinospora cordifolia (Willd.) Miers for the Treatment of Kidney Diseases

   Gaurav Gaurav, Mohammad Umar Khan, Parakh Basist, Sultan Zahiruddin, Mohammad Ibrahim, Rabea parveen, Anuja Krishnan, Sayeed Ahmad

   pp. 548–558 · DOI: 10.4103/pm.pm_582_21 · 2022

   Background: Tinospora cordifolia (Willd.) Miers (T. cordifolia) is a well‑known Indian medicinal plant containing several nonpolar and polar constituents that play an important role to mitigate various ailments, such as …

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6. Article

   A Comparative Pharmacognostical Evaluation and Simultaneous HPTLC Quantification of Bioactive Alkaloids in Three Species of Gloriosa, Collected from Natural Habitat in India

   Ankita Misra, Bhanu Kumar, Sharad Srivastava

   pp. 559–564 · DOI: 10.4103/pm.pm_580_21 · 2022

   Background: The genus Gloriosa is commercially valued due to its colchicine metabolite, which is clinically used in gout and as an antimitotic agent. Objectives: The study was a comparative pharmacognostical evaluation a…

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7. Article

   Apoptosis‑Mediated Inhibition of Human Gastric Cancer Cell Proliferation by Cirsilineol

   Mohammed Ali, Ahmed Al-Ghamdi

   pp. 565–570 · DOI: 10.4103/pm.pm_75_22 · 2022

   Background: Flavonoids constitute one of the best‑characterized groups of plant secondary metabolites with enormous pharmaceutical potential. A flavone type of plant flavonoid, cirsilineol, has been reported to exhibit p…

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8. Article

   Alterations in the Pharmacokinetics of Paeoniflorin and Albiflorin in a Collagen‑Induced Arthritis Rat Model

   Ya-xin Han, Mu-xin Gong, Jin-e Peng, Yong-song Xu, Feng Qiu, Kai-li Xie, Xue-rong Dong, Bin-bin Wang, Xiao-xin Chai, Zhe Ma, Si-hui Wang, Nan Nan

   pp. 571–578 · DOI: 10.4103/pm.pm_539_21 · 2022

   Background: Rheumatoid arthritis (RA) is an autoimmune disease that seriously affects the patient’s quality of life. Total glucosides of peony (TGP) have long been used to treat RA in China despite the need for long‑term…

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9. Article

   Notoginsenoside R1 Elicits Inhibitory Effects on Keloid Fibroblasts via Downregulation of Vascular Endothelial Growth Factor

   Weiping Huang, Jin Chen, Tao Zhu

   pp. 579–586 · DOI: 10.4103/pm.pm_359_21 · 2022

   Background: Keloid is a fibrotic disease characterized by hyperproliferative fibroblasts. Notoginsenoside R1 (NGR1) possesses inhibitory roles on cell proliferation. Thus, the research sought to assess the mechanism of a…

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10. Article

    Anticancer Potential of Brucine against Oral Cancer Cells in vitro through Elevation of Reactive Oxygen Species

    Yahya H. Hobani

    pp. 587–592 · DOI: 10.4103/pm.pm_126_22 · 2022

    Background: Oral cancer is one of the cancers that pose a great threat to life globally. Though a number of chemotherapeutic strategies have been followed to treat oral cancer, a number of adverse effects limit the usage…

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11. Article

    Adhatoda vasica is Effective in Relieving Pain through Modulation of Inflammation

    Li Gao, Shasha Cui, Zhiqiang Huang, Hailong Cui

    pp. 593–599 · DOI: 10.4103/pm.pm_114_22 · 2022

    Background: Nociception is an unpleasant experience that has a negative effect on both the physiological and psychological status of individuals. Factors including temperature, and physical damage originating from mechan…

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12. Article

    Sinomenine Activates Gut Innate Immune Response through the Aromatic Hydrocarbon Receptor by Regulating the IL‑23/IL‑17 Axis

    Weina Zhu, Chunhua Ma, Jie Ruan, Fuqiong Zhou, Yajie Zhang, Hongyan Long

    pp. 600–605 · DOI: 10.4103/pm.pm_81_21 · 2022

    Background: Sinomenine (SIN) plays a role in regulating intestinal immune inflammation, but its effect on the intestinal immune response is unclear.Objective: To investigate the potential mechanism of SIN in protecting i…

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13. Article

    Molecular Mechanisms of Dolichandrone serrulata Flower Ethanolic Extract on Antimigration of Human Cervical Cancer Cell Line

    Patcharawan Sujayanont, Ratikorn Chatchanayeunyong

    pp. 606–610 · DOI: 10.4103/pm.pm_45_22 · 2022

    Background: Dolichandrone serrulata flower has been known for its antioxidation and anti‑inflammation. Its ability to induce cell death and reduce migration on cancer cell lines has been previously demonstrated. Aim: The…

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14. Article

    Synthesis of Baicalin Carboxylate Derivatives and their Structure–Activity Relationship Analysis of their Inhibitory Activity on BVDV NS5B Polymerase

    Ying Zong, Yu H. Sun, Yi Che, Hui Wang, Kun Shi, Zhong M. He, Rui Du

    pp. 611–620 · DOI: 10.4103/pm.pm_561_21 · 2022

    Background: Bovine viral diarrhea virus (BVDV) has a serious impact on the global livestock industry; however, there are no specific therapeutic drugs for BVDV, so the development of anti‑BVDV drugs is a research priorit…

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15. Article

    Oroxylum indicum (L.) Kurz Seed Extract Prevents LPS‑Mediated BV2 Microglial Activation through NF‑κB Nuclear Translocation and Activation of the Akt/ERK1/2 Signaling Pathways

    Nootchanat Mairuae, Poonlarp Cheepsunthorn, Benjaporn Buranrat

    pp. 621–626 · DOI: 10.4103/pm.pm_122_22 · 2022

    Background:Oroxylum indicum (L.) Kurz is an edible plant that is widely consumed in several Asian countries. In our previous study, it was demonstrated that Oroxylum indicum (L.) Kurz seed (OIS) extract attenuated oxidat…

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16. Article

    Anti‑inflammatory Effect of luteolin‑7‑O‑glucoside via the JAK1/ STAT6/SOCS1 Pathway in Ulcerative Colitis Treatment

    Dajuan Sun, Yan Cheng, Hua Yan, Xiunan Wei, Xinqian Dong, Lili Chi

    pp. 627–634 · DOI: 10.4103/pm.pm_506_21 · 2022

    Background: Luteolin‑7‑O‑glucoside (Lut‑7‑G) is an effective compound found in plants, such as Patrinia and honeysuckle. It has anti‑inflammatory as well as antioxidant properties; however, its anti‑inflammatory effect o…

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17. Article

    Anti‑cancer and Cell Toxicity Effects of Royal Jelly and its Cellular Mechanisms against Human Hepatoma Cells

    Sultan F. Alnomasy, Zafer Saad Al Shehri

    pp. 635–640 · DOI: 10.4103/pm.pm_18_22 · 2022

    Background: This investigation was planned to evaluate the anti‑cancer effects of royal jelly (RJ) obtained from Apis mellifera compared with doxorubicin as an anthracycline with potent anti‑cancer activity and its cellu…

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18. Article

    Salvianolic Acid B Delays Hepatolithiasis through Inhibiting the Fibrosis of Intrahepatic Biliary Epithelial Cells

    Hao Yao, Wenpin Xu, Zhaoming Liu, Dawei Ma, Hongbin Bao

    pp. 641–650 · DOI: 10.4103/pm.pm_162_21 · 2022

    Background: Hepatolithiasis (HL) is one of the common diseases in hepatobiliary surgery, and bile duct fibrosis is the key step in the pathogenesis of HL. Salvia miltiorrhiza (S. miltiorrhiza) has an inhibitory effect on…

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19. Article

    Terfezia claveryi Chatin: Anti‑Tumor Effects against Ehrlich Solid Tumor in Mice

    Norah A. Althobaiti, Reem Hasaballah Alhasani, Mona N. BinMowyna, Aishah E Albalawi, Ifat Alshari

    pp. 651–658 · DOI: 10.4103/pm.pm_12_22 · 2022

    Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic activities of <em>Crotal…

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20. Article

    Components with Lifespan‑prolonging Effects in the Fibrous Roots of Anemarrhena asphodeloides Characterized by UltraHigh Performance

    Jianhong Li, Qi Huang, Deling Wu, Rumin Zong, Zhiyuan Shao, Yu Meng, Qianqian He

    pp. 659–668 · DOI: 10.4103/pm.pm_447_21 · 2022

    Background/Context:The fibrous roots of Rhizoma Anemarrhena (FRRA) are produced in the primary processing of Rhizoma Anemarrhena (RA). The lifespan‑prolonging effect and the bioactive compounds of FRRA were rarely report…

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