Table of Contents

Linyin Yan, Yu Zhang, Decai Dai, Yanqiang Li, Wei Xiao

pp. 727–737 · DOI: 10.1177/09731296241299498 · 2025

Hemostatic disorders are the leading cause of morbidity and even mortality worldwide. Therefore, there is a growing tendency to develop novel, effective, and safer agents for the management of hemostatic diseases. Curren…

Shuang Yan, Yawei Wang, Jing Zeng, Dan Liu, Haichuan Qin, Chengzhen Du, Qiao Xiang, Li Yang, Ling Li, Yuxin He

pp. 738–750 · DOI: 10.1177/09731296241309963 · 2025

Background: Melanoma is a highly invasive and metastatic malignant tumor, with pathogenesis involving multiple signaling pathways and transcription factors. Current treatments face significant challenges, including drug …

Pankaj Dagur, Manik Ghosh

pp. 751–764 · DOI: 10.1177/09731296241305858 · 2025

Lac has been attracting the scientific community’s attention since time immemorial, aided by its wide-ranging applicability in the textile, plastic, metallurgy, and food industries. Lac exudate comprises three primary co…

Liang Chen, Shijie Lan, Sisi Shen, Jiahui Wang, Xuesong Liu, Botao Jiang, Peng Zhong, Bochao Liu, Shuang Yao, Pingwei Qin, Wanyu Feng

pp. 765–780 · DOI: 10.1177/09731296241276640 · 2025

Background: Bovine viral diarrhea/mucosal disease (BVD-MD) is widely distributed worldwide. The disease causes serious economic losses to animal husbandry every year. Finding targeted antiviral drugs proves to be an effe…

Xu Zhang, Xiao-Ting Zhang, Shi-Yu Wu, Ming-Qiao Hu, Xu Xu, Jian-Ping Gao

pp. 781–792 · DOI: 10.1177/09731296241289678 · 2025

Background: Inflammation mediated by hyperglycemia, lipid metabolism disorders, abnormal myocardial energy metabolism, myocardial cell damage, and changes in ventricular structure are important mechanisms in the occurren…

Chao Gao, Shunzhan Su, Qi Guan, Xiaoxia Huang, Haichuan Tan, Zhuang Qiu, Lili Su, Shengcao Cao

pp. 793–804 · DOI: 10.1177/09731296241305861 · 2025

Background: Gliomas are the most aggressive and devastating brain tumors, with a poor prognosis due to their complex etiology, diverse clinical manifestations, and the limited efficacy of existing treatment methods. Obje…

Huiying Zhao, Yongshou Xia

pp. 805–817 · DOI: 10.1177/09731296241307453 · 2025

Background: Natural compounds with radioprotective properties have gained attention due to their potential to reduce health risks associated with radiation exposure. Galangin (GA), a flavonoid recognized for its antioxid…

Abdullah Alqarni, Jagadish Hosmani, Khalil Assiri, Saeed Alassiri, Ali Mosfer Alqahtani

pp. 818–830 · DOI: 10.1177/09731296241299496 · 2025

Background: Osteosarcoma, the predominant primary bone cancer in the pediatric and adolescent population globally, exhibits a relatively low annual incidence but contributes significantly to morbidity and mortality. Obje…

Qing Liu, Ying Lan, Zhe Bai

pp. 831–841 · DOI: 10.1177/09731296241306199 · 2025

Background: Hyperoside is a potential liver cell and mitochondrial protector, but there is no evidence to suggest that hyperoside can effectively treat doxorubicin (DOX) related liver toxicity. Objectives: This study aim…

Qiao Ling Yu, Guang Xiu Wu, Kai Wen Tan, Ying Liang, Shuang Shuang Qin, Fan Wei, Jin Yuan Cai, Ling Yun Chen, Guo Yong Xie, Ming Zhai, Kun Hua Wei

pp. 842–854 · DOI: 10.1177/09731296241307086 · 2025

Background: Genistein and genistin are the main active constituents of Flemingia macrophylla (Willd.) Prain and the amount of active constituents in the roots varies depending on the cultivation time. The harvesting peri…

Xiaoyan Lv, Yanlong He, Yanhong Zhang

pp. 855–864 · DOI: 10.1177/09731296241305943 · 2025

Background: Acute lung injury (ALI) is an acute inflammatory condition defined by the excessive generation of inflammatory chemicals in lung tissue. Solasodine, a glycoalkaloid isolated from Solanum species, has been pro…

and can further recruit substances such as Smad, its Relationship with BMP-Smad Pathway Yini Mao, Jun Li, Feifei Zhang

pp. 865–876 · DOI: 10.1177/09731296241305868 · 2025

Background: Fracture healing involves multiple growth factors and the interaction between multiple signaling pathways. Pue (puerarin) is a natural compound with multiple biological activities, but its effect on fracture …

Vakkalagadda Siva Ganesh, Prakash Goudanavar, N Raghavendra Naveen, Girish Meravanige Basavarajappa, Afzal Haq Asif, Predeepkumar Narayanappa Shiroorkar, Bharathi D R, Sreeharsha Nagaraja

pp. 877–884 · DOI: 10.1177/09731296241299495 · 2025

Background: Metyrapone inhibits 11 β-hydroxylase, contributing to adrenal insufficiency (AI). This study aims to explore the efficacy of Tribulus terrestris fruit extract (TTFE) and an isolated compound (hecogenin) on me…

Lisha Li, Xiaoping Yang, Zhuo Cai, Bin Yin, Wenqing Jiang

pp. 885–894 · DOI: 10.1177/09731296241305864 · 2025

Background: Asthma is a chronic inflammatory condition of the airways, leading to excessive production of mucus and an inflammatory condition of the lungs. The primary clinical manifestations of asthma comprise thoracic …

Jiayong Huang, Binbo Fang, Ting Guo, Yiyang Li, Yilin Yang, Jiongcheng Ying, Haoyun Zhou, Xiang Li

pp. 895–905 · DOI: 10.1177/09731296241311343 · 2025

Background: Activation of PRR11 contributes to the progression of lung cancer and is related to its methylation status. However, the regulatory mechanism of luteolin-zinc (Lu-Zn) on PRR11 methylation-mediated lung cancer…

Zhao Liu, Jian Xu, Heng Xia, Miaofeng Wang, Qianlan Xu

pp. 906–916 · DOI: 10.1177/09731296241311986 · 2025

Background: Malignant tumors represented by breast cancer still have limitations in clinical treatment methods. Matrine is a compound with anticancer activity, but its inhibitory effect on breast cancer and its mechanism…

Haiping Zhang, Dan Mei, Meina Li

pp. 917–928 · DOI: 10.1177/09731296241297429 · 2025

Background: Cedrin is a major bioactive flavonoid compound present in the Cedrus deodara plant and has been reported to have several biological activities. Diabetes mellitus is an endocrine and metabolic disease marked b…

Ayman Saeed Alhazmi

pp. 929–938 · DOI: 10.1177/09731296241300871 · 2025

Background: Cardiovascular disease continues to be a predominant source of morbidity and mortality globally. Commiphora gileadensis L. is a tree under the genus Commiphora. Objectives: To investigate the anti-inflammator…

Jie Qi, Lili Gao

pp. 939–947 · DOI: 10.1177/09731296241297432 · 2025

Background: One of the most effective anticancer medications for treating a range of cancers is cisplatin (Cis). Its use is limited because of its nephrotoxicity. Objectives: This study aims to evaluate the role of linar…

Yuning Wang, Dan Wu

pp. 948–958 · DOI: 10.1177/09731296241297431 · 2025

Background: One of the leading causes of acute brain injury is cerebral ischemia/reperfusion (I/R) injury. It is an ailment that occurs when the brain does not receive enough oxygen-rich blood supply, which damages brain…