Table of Contents

Original Article

1. Article

   S1 Cytotoxic glucosphingolipid from Celtis Africana

   Shagufta Perveen, Areej Mohammad Al‑Taweel, Ghada Ahmed Fawzy, Azza Muhammed El‑Shafae, Afsar Khan, Peter Proksch

   pp. 1–5 · DOI: 10.4103/0973-1296.157662 · 2015

   Background: Literature survey proved the use of the powdered sun‑dried bark and roots of Celtis africana for the treatment of cancer in South Africa. Objective: The aim of this study was to do further isolation work on t…

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2. Article

   Cytotoxicity of some edible mushrooms extracts over liver hepatocellular carcinoma cells in conjunction with their antioxidant and antibacterial properties

   Gökhan Sadi, Buğrahan Emsen, Abdullah Kaya, Aytaç Kocabaş, Seval Çınar, Deniz İrtem Kartal

   pp. 6–18 · DOI: 10.4103/0973-1296.157665 · 2015

   Background: Mushrooms have been valued for their nutritive content and as traditional medicines; several important medicinal properties of mushrooms have been recognized worldwide. Objective: The purpose of this study wa…

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3. Article

   S19 Pharmacophore modeling, in silico screening, molecular docking and molecular dynamics approaches for potential alpha‑delta bungarotoxin‑4 inhibitors discovery

   R. Barani Kumar, M. Xavier Suresh, B. Shanmuga Priya

   pp. 19–28 · DOI: 10.4103/0973-1296.157670 · 2015

   Background: The alpha‑delta bungartoxin‑4 (α‑δ‑Bgt‑4) is a potent neurotoxin produced by highly venomous snake species, Bungarus caeruleus, mainly targeting neuronal acetylcholine receptors (nAchRs) and producing adverse…

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4. Article

   S29 Antimutagenic potential of harpagoside and Harpagophytum procumbens against 1‑nitropyrene

   Luigi Manon, Baghdikian Béatrice, Orsière Thierry, Pompili Jocelyne, Mabrouki Fathi, Ollivier Evelyne

   pp. 29–36 · DOI: 10.4103/0973-1296.157675 · 2015

   Background: 1‑nitropyrene (1‑NPy) is one of the most abundant nitro‑polycyclic aromatic hydrocarbons particularly in diesel exhausts. It is a mutagenic and carcinogenic pollutant very widespread in the environment. So th…

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5. Article

   S37 Cytotoxic and apoptotic effects of Ebenus boissieri Barbey on human lung cancer cell line A549

   Esra Arslan Aydemir, Ece Simsek, Nilüfer Imir, Ramazan Süleyman Göktürk, Erdem Yesilada

   pp. 37–45 · DOI: 10.4103/0973-1296.157679 · 2015

   Background: Fabaceae family members are known to possess preventive and therapeutic potentials against various types of cancers. Objective: The aim of this study was to investigate the cytotoxic and apoptotic effects of …

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6. Article

   Antiproliferative efficacy of Tabernaemontana divaricata against HEP2 cell line and Vero cell line

   Arvind Kumar, S. Selvakumar

   pp. 46–52 · DOI: 10.4103/0973-1296.157682 · 2015

   Background: Laryngeal cancer may also be called cancer of the larynx or laryngeal carcinoma. Conventional plants are a precious source of novel anticancer agents and are still in performance better role in health concern…

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7. Article

   Assay method for quality control and stability studies of a new anti‑diabetic and anti‑dyslipidemic flavone (S002‑853)*

   Arshi Naqvi, Anuja Pandey, Varsha Gupta, Richa Malasoni, Akansha Srivastava, Rishi Ranjan Pandey, M. Satyanarayana, Ram Pratap, Anil Kumar Dwivedi

   pp. 53–59 · DOI: 10.4103/0973-1296.157689 · 2015

   Background: Flavonoid‑rich extract of the plant is long known for its anti‑diabetic activities in traditional medicine. S002‑853, a new flavone derivative synthesized by Central Drug Research Institute (CDRI) has been us…

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8. Article

   Use of bergenin as an analytical marker for standardization of the polyherbal formulation containing Saxifraga ligulata

   Hulikal Basavarajaiah Pushpalatha, Kumar Pramod, Rajendran Devanathan, Ramachandran Sundaram

   pp. 60–65 · DOI: 10.4103/0973-1296.157690 · 2015

   Background: Bergenin is the principle constituent of the well-known medicinal plant Saxifraga ligulata. Bergenin has anti-inflammatory, antipyretic, antiviral, immunostimulant, antihyperglycemic, and antioxidant properti…

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9. Article

   A novel high‑performance liquid chromatography‑electron spray ionization‑mass spectrometry method for simultaneous determination of guggulsterones, piperine and gallic acid in Triphala guggulu

   Ganesh Muguli, P. R. Rao Vadaparthi, B. Ramesh, Vishakante Gowda, Rangesh Paramesh, Atul N. Jadhav, K. Suresh Babu

   pp. 66–72 · DOI: 10.4103/0973-1296.157696 · 2015

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10. Article

    S73 Anti‑lung cancer potential of pure esteric‑glycoside condurangogenin A against nonsmall‑cell lung

    cancer cells in vitro via p21/p53 mediated cell cycle

    pp. 73–85 · DOI: 10.4103/0973-1296.157698 · 2015

    Background: Marsdenia condurango (condurango) is a tropical woody vine native to South America. Our earlier study was limited to evaluation of anti‑cancer potentials of crude condurango extract and its glycoside‑rich com…

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11. Article

    Protective effect of young green barley leaf (Hordeum vulgare L.) on restraint stress‑induced decrease in hippocampal brain‑derived neurotrophic factor in mice

    Katsunori Yamaura, Riho Tanaka, Yuanyuan Bi, Hideki Fukata, Nobuo Oishi, Hiromi Sato, Chisato Mori, Koichi Ueno

    pp. 86–92 · DOI: 10.4103/0973-1296.157702 · 2015

    Background: Many health experts support the hypothesis that stressful lifestyles are the leading cause of illness, like depression. Therefore, from the standpoint of preventive medicine, it is important to reduce stress.…

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12. Article

    S93 Toxicological and biochemical studies on Schinus terebinthifolius concerning its curative and hepatoprotective effects against carbon tetrachloride‑induced liver injury

    Rania H. Abdou, Sherif Y. Saleh, Waleed F. Khalil

    pp. 93–101 · DOI: 10.4103/0973-1296.157705 · 2015

    Background: Recently, many efforts have been made to discover new products of natural origin which can limit the xenobiotic‑induced hepatic injury. Carbon tetrachloride (CCl4) is a highly toxic chemical that is widely us…

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13. Article

    Flavonoid profile, antioxidant and cytotoxic activity of different extracts from Algerian Rhamnus alaternus L. bark

    Soulef Boussahel, Antonio Speciale, Saliha Dahamna, Yacine Amar, Irene Bonaccorsi, Francesco Cacciola, Francesco Cimino, Paola Donato, Guido Ferlazzo, Daoud Harzallah, Mariateresa Cristani

    pp. 102–109 · DOI: 10.4103/0973-1296.157707 · 2015

    Background: Rhamnus alaternus (Rhamnaceae) L. has been traditionally used for treatment of many diseases. Objective: In this study, we determined the antioxidant/free radical scavenger properties, the flavonoid profile a…

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14. Article

    Inhibitory potential of some Romanian medicinal plants against enzymes linked to neurodegenerative diseases and their antioxidant activity

    Gabriela Paun, Elena Neagu, Camelia Albu, Gabriel Lucian Radu

    pp. 110–116 · DOI: 10.4103/0973-1296.157709 · 2015

    Context: Eryngium planum, Geum urbanum and Cnicus benedictus plants are an endemic botanical from the Romanian used in folk medicine. Objective: The extracts from three Romanian medicinal plants were investigated for the…

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15. Article

    Experimental treatment of breast cancer‑bearing BALB/c mice by artemisinin and transferrin‑loaded magnetic nanoliposomes

    Amir Gharib, Zohreh Faezizadeh, Seyed Ali Reza Mesbah‑Namin, Ramin Saravani

    pp. 117–122 · DOI: 10.4103/0973-1296.157710 · 2015

    Background: The combination of artemisinin and transferrin exhibits versatile anticancer activities. In previous, we successfully prepared artemisinin and transferrin‑loaded magnetic nanoliposomes and evaluated their ant…

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16. Article

    In silico analysis and molecular docking studies of potential angiotensin‑converting enzyme inhibitor using quercetin glycosides

    Syed Aun Muhammad, Nighat Fatima

    pp. 123–126 · DOI: 10.4103/0973-1296.157712 · 2015

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17. Article

    Methanol extract of wheatgrass induces G1 cell cycle arrest in a p53‑dependent manner and down regulates the expression of cyclin D1 in human laryngeal cancer cells‑an in vitro and in silico approach

    Garima Shakya, Sangeetha Balasubramanian, Rukkumani Rajagopalan

    pp. 139–147 · DOI: 10.4103/0973-1296.157715 · 2015

    Background: Deregulation of cell cycle has been implicated in the malignancy of cancer. Since many years investigation on the traditional herbs has been the focus to develop novel and effective drug for cancer remedies. …

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18. Article

    The dose dependent in vitro responses of MCF- 7 and MDA-MB-231 cell lines to extracts of Vatica diospyroides symington type SS fruit include effects on mode of cell death

    Theera Srisawat, Yaowapa Sukpondma, Potchanapond Graidist, Siriphon Chimplee, Kanyanatt Kanokwiroon

    pp. 148–155 · DOI: 10.4103/0973-1296.157718 · 2015

    Background: Vatica diospyroides type LS is a known source of valuable compounds for cancer treatment, however, in contrast little is known about therapeutic efficacy of type SS. Objective: This study focused on in vitro …

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19. Article

    Cytotoxic activity of Macrosolen parasiticus (L.) Danser on the growth of breast cancer cell line (MCF‑7)

    Vijay Kumar Sodde, Richard Lobo, Nimmy Kumar, Rajalekshmi Maheshwari, C. S. Shreedhara

    pp. 156–160 · DOI: 10.4103/0973-1296.157719 · 2015

    Background: Macrosolen parasiticus (L.) Danser belonging to Loranthaceaea (mistletoe family) is a parasitic plant that grows on different host plants such as mango, jack fruit, peepal, neem tree, etc., This study was aim…

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20. Article

    Effects of the extract and glycoalkaloids of Solanum lycocarpum St. Hill on Giardia lamblia trophozoites

    Gilmarcio Z. Martins, Raquel R. D. Moreira, Cleopatra S. Planeta, Adélia E. Almeida, Jairo K. Bastos, Lígia Salgueiro, Carlos Cavaleiro, Maria do Céu Sousa

    pp. 161–165 · DOI: 10.4103/0973-1296.157721 · 2015

    Background: Solanum lycocarpum has great importance for food and medicinal traditional use. Recently, it was also evidenced that extracts of S. lycocarpum St. Hill (Solanaceae) and its glycoalkaloids, solamargine (Sg) an…

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