Table of Contents

Original Research Article(continued)

1. Article

   GRg1 Ameliorates Insulin Resistance Through Activation of the PI3K/AKT/GSK-3β Pathway in HepG2 Cells

   Xunjun Shen, Yamei Jin, Yuting Chen, Huadi Yang

   pp. 257–267 · DOI: 10.1177/09731296231198284 · 2024

   Background: Insulin resistance (IR) is a pathological state closely associated with various diseases, with hepatic insulin resistance playing a pivotal role. Insulin resistance can be improved by Ginsenoside Rg1 (GRg1), …

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2. Article

   Plumbagin Attenuates Ovalbumin-induced Allergic Asthma in Mice through Inhibition of Inflammatory Response

   Dong Yiming, Abdullah R Alzahrani, Abubucker Peer Mohideen

   pp. 268–279 · DOI: 10.1177/09731296231184537 · 2024

   Background: Asthma is a prominent non-communicable inflammatory disease that affects both children and the elderly. Younger people are more prone to asthma, and most prescribed anti-asthmatic medicines relieve symptoms b…

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3. Article

   Modulations by L-Carvone and Thymoquinone to Exert Protection on Bone Marrow Cells Against Benzene-induced Toxicities Through Anti-inflammatory Pathways in SD Rats

   Enjun Kong, Yan Xu, Hong Jin, Tahani Awad Alahmadi, Samer Hasan Hussein Al Ali

   pp. 280–290 · DOI: 10.1177/09731296231201510 · 2024

   Background: Adverse effects of benzene (BZ) exposure toxicities were documented by many researchers worldwide. BZ exposure causes many hematological abnormalities that might be treated with naturally occurring phytocompo…

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4. Article

   Shexiang Tongxin Dropping Pretreated Mesenchymal Stem Cells-derived Exosomes Attenuate Cardiac Ischemia/Reperfusion Injury by Modulating miR-182-5p and miR-199a-3p-mediated Inflammatory Responses

   Ling-Yan Li, Ling-Fang Zhou, Jia Shi, Zong-Jun Liu, Jun-Qing Gao

   pp. 291–302 · DOI: 10.1177/09731296231207232 · 2024

   Background: Previous research has highlighted the regulatory role of miR-182-5p in targeting TLR4 during the pathogenesis of allergic rhinitis. In a different context, TLR4 has been identified as a crucial factor in the …

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5. Article

   Screening of Chenopodium hybridum L. for Anti-ovarian Cancer Compounds Using UPLC-Q-Exactive MS and Partial Least Squares Analysis

   Shuli Yang, Duanduan Cheng, Xueqin Feng, Ruixin Lin

   pp. 303–315 · DOI: 10.1177/09731296231198930 · 2024

   Background: Extracts of Chenopodium hybridum L. leaves and stems exerted a significant anti-proliferative effect on human A2780 ovarian cancer cells, but C. hybridum active components have not been reported. Materials an…

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6. Article

   Gastrodin Ameliorates Knee Joint Inflammation and Pain in Osteoarthritis Rats and Prevents Chondrocyte Injury by Regulating PI3K/Akt/FoxO1 Pathway

   Jiang-Long Shi, Li-Yun Liu, Yu-Ting Dong, Tao Shen

   pp. 316–327 · DOI: 10.1177/09731296231203860 · 2024

   Background: Several studies have demonstrated the anti-inflammatory properties of gastrodin. However, its specific role and mechanism in the context of osteoarthritis (OA) remain unclear. Objectives: The objective of thi…

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7. Article

   Functional Properties of the Water Extract from Eriocheir sinensis (Chinese mitten crab) Via Evaluation of Protective Effects on Reflux Esophagitis Model

   Hyeon Hwa Nam, Jun Ho Song, Jun Lee, Byeong Cheol Moon, Sumin Noh, Li Nan, Byung Kil Choo, Joong-Sun Kim

   pp. 328–335 · DOI: 10.1177/09731296231189324 · 2024

   Objectives: In the study, we investigated the effects of an Eriocheir sinensis water extract on a reflux esophagitis-induced rat model. Background: The crab has been used as a traditional medicine and food source in many…

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8. Article

   Prunetin Triggers ROS-mediated Apoptosis through the Suppression of MAPKs/STAT-3/NF-κB-p65 Signaling Pathway in Human Osteosarcoma Cells

   Meng Gao, Ya Wang, Weibo Liu, Zelong Song, Xiangyu Wang, Xuesong Zhang

   pp. 336–346 · DOI: 10.1177/09731296231188784 · 2024

   Background: Osteosarcoma (OS) is a highly metastatic primary bone malignancy, and the treatment options remain inadequate. Hence, exploring innovative natural medications is required. Prunetin (PRU) is an isoflavone that…

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9. Article

   Anti-convulsant Effects of Scutellarein in a PTZ Kindling Model in Mice

   Jun Duan, Jiao Wang, Qian Zhao, Dean Wu, Yang Liu

   pp. 347–356 · DOI: 10.1177/09731296231203790 · 2024

   Background: Epilepsy is a chronic neurological condition with various underlying mechanisms. It is known to affect a multitude of people across the globe, regardless of age and gender. Seizures associated with epilepsy i…

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